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Hypoxia enhances ligand-occupied androgen receptor activity.

Abstract：

:Hypoxia and the androgen receptor (AR) play important roles in the development and progression of prostate cancer. In this study, the combined effects of dihydrotestosterone (DHT) and hypoxia on AR-mediated transactivation were investigated. Hypoxia alone did not induce a detectable ARE-mediated response in the absence of DHT. DHT-induced AR transcriptional activity was dramatically increased by hypoxia or ectopic expression of HIF-1α, as determined by introducing ARE-responsive reporter plasmids into LNCaP prostate cancer cells. The secretion of VEGF was enhanced by the combination of hypoxia and DHT as compared to each treatment alone. These effects were not due to increased expression of the AR or HIF-1α as a result of hypoxia and DHT treatment. These results provide evidence that hypoxia may stimulate as yet unknown factors, which further stimulate AR signal transduction pathways.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Park C,Kim Y,Shim M,Lee Y

doi

10.1016/j.bbrc.2012.01.019

subject

Has Abstract

pub_date

2012-02-10 00:00:00

pages

319-23

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00042-3

journal_volume

418

pub_type

杂志文章

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