当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: probably an indirect action via the regulation of NFκB/FasL circuitry.

Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: probably an indirect action via the regulation of NFκB/FasL circuitry.

Abstract：

:The Fas/FasL signaling pathway, controlled by nuclear factor-κB (NFκB) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), a component of the Mi-2/nucleosome remodeling and deacetylase complex, was upregulated in SCs during the early recovery after MEHP exposure. This expression change was in line with the dynamic changes in germ cell apoptosis in response to MEHP treatment. Furthermore, a knockdown of MTA1 by RNAi in SCs was found to impair the MEHP-induced early activation of NFκB pathway and abolish the recruitment of NFκB onto FasL promoter, which consequently diminished the MEHP-triggered FasL induction. Considering that Fas/FasL is a well characterized apoptosis initiating signaling during SCs injury, our results point to a potential "switch on" effect of MTA1, which may govern the activation of NFκB/FasL cascade in MEHP-insulted SCs. Overall, the MTA1/NFκB/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after SCs injury.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen S,Dong Y,Xu C,Jiang L,Chen Y,Jiang C,Hou W,Li W

doi

10.1016/j.bbrc.2013.09.135

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

749-55

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)01640-9

journal_volume

440

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Iron participated in breast cancer chemoresistance by reinforcing IL-6 paracrine loop.

    abstract：:Chemotherapeutic efficacy is also regulated by the tumor microenvironment. IL-6 produced by TAMs and downstream IL-6/STAT3 signaling pathway is central regulator in chemotherapeutic response. The M2-like phenotype of TAMs is characterized by elevated iron uptake. Whether iron participates in chemo-resistance need to b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.05.064

    authors： Li J,He K,Liu P,Xu LX

    更新日期：2016-06-24 00:00:00

  • Interleukin-1: a cytokine that has potent antisecretory and anti-ulcer actions via the central nervous system.

    abstract：:The present study was performed to determine if interleukin-1 (IL-1) acts as a chemical messenger in the central nervous system (CNS) regulation of gastric secretion and ulcer formation, using male Wistar rats. The central injection of IL-1 dose-dependently inhibited gastric acid secretion in pylorus-ligated rats at 1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80075-0

    authors： Uehara A,Okumura T,Kitamori S,Takasugi Y,Namiki M

    更新日期：1990-12-14 00:00:00

  • Generation of ERα-floxed and knockout mice using the Cre/LoxP system.

    abstract：:Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ERα mouse line that can be used to knock out ERα in selected tissues by using the Cre/LoxP system. In this study, we established a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.07.016

    authors： Antonson P,Omoto Y,Humire P,Gustafsson JÅ

    更新日期：2012-08-10 00:00:00

  • A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.

    abstract：:Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.091

    authors： Giannoni E,Raugei G,Chiarugi P,Ramponi G

    更新日期：2006-09-22 00:00:00

  • Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia.

    abstract：:The p53 homologue p73 is expressed in at least six different isoforms (alpha, beta, gamma, delta, epsilon, and zeta), but unlike p53 it has rarely been found mutated in human cancers. However, altered expression of this gene has been reported in cancer cells. In order to understand if p73 is involved in normal and mal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3627

    authors： Tschan MP,Grob TJ,Peters UR,Laurenzi VD,Huegli B,Kreuzer KA,Schmidt CA,Melino G,Fey MF,Tobler A,Cajot JF

    更新日期：2000-10-14 00:00:00

  • Supramolecular surfactants: amphiphilic polymers designed to disrupt lipid membranes.

    abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90031-4

    authors： Regen SL,Jayasuriya N,Fabianowski W

    更新日期：1989-03-15 00:00:00

  • Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.

    abstract：:An XWnt8-Fz5 fusion protein synergizes with LRP6 to potently activate beta-catenin-dependent signaling. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling. Based on this, we hypothesi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.009

    authors： Holmen SL,Robertson SA,Zylstra CR,Williams BO

    更新日期：2005-03-11 00:00:00

  • Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.

    abstract：:Opening of high conductance permeability transition pores in mitochondria initiates onset of the mitochondrial permeability transition (MPT). The MPT is a causative event, leading to necrosis and apoptosis in hepatocytes after oxidative stress, Ca(2+) toxicity, and ischemia/reperfusion. CsA blocks opening of permeabil...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-291x(03)00618-1

    authors： Kim JS,He L,Lemasters JJ

    更新日期：2003-05-09 00:00:00

  • Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.

    abstract：:Cardiolipin and phosphatidic acid-binding protein (CLPABP) controls the stability of the mRNA harboring an AU-rich element (ARE) in the 3' UTR with the help of the RNA stabilizer, human antigen R (HuR). Although CLPABP is localized on the mitochondrial surface as a large protein-RNA complex, its precise role is not ye...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.112

    authors： Maeda A,Uchida M,Nishikawa S,Nishino T,Konishi H

    更新日期：2018-01-01 00:00:00

  • Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference.

    abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.173

    authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

    更新日期：2005-10-28 00:00:00

  • Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro.

    abstract：:We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to IR, respectively, were treated with the combinations of FTD and IR, and evaluated by the clonog...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.044

    authors： Matsuoka K,Kobunai T,Nukatsuka M,Takechi T

    更新日期：2017-12-09 00:00:00

  • Regulation of HSF1-responsive gene expression by N-terminal truncated form of p73alpha.

    abstract：:DNp73 is a transactivation domain (TAD)-truncated form of p73. The ability of DNp73alpha to regulate gene expression was examined using reporter assays with luciferase gene constructs. Among various promoter-regulated reporter genes tested, heat shock factor (HSF)-responsive gene expression was selectively activated b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.124

    authors： Tanaka Y,Kameoka M,Itaya A,Ota K,Yoshihara K

    更新日期：2004-05-07 00:00:00

  • Structural basis for efonidipine block of a voltage-gated Ca2+ channel.

    abstract：:Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.176

    authors： Xu F,Xiong W,Huang Y,Shen J,Zhou D,Tang L

    更新日期：2019-06-04 00:00:00

  • Pax2a is expressed in oocytes and is responsible for early development and oogenesis in zebrafish.

    abstract：:Eleven genes, including pax2a, were selected as candidate ovulation-inducing genes on the basis of microarray analysis and RNA sequencing in our previous study. The purpose of this study was to investigate the role of the pax2a gene in the ovulation-inducing process. F2 pax2a homozygous mutant zebrafish possessing a d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.09.059

    authors： Pachoensuk T,Fukuyo T,Wanlada K,Rezanujjaman M,Rahaman MM,Sasaoka K,Sarwar Jyoti MM,Rana MR,Ali MH,Tokumoto T

    更新日期：2020-12-10 00:00:00

  • Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart.

    abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2144

    authors： Ladoux A,Frelin C

    更新日期：1993-09-15 00:00:00

  • The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.

    abstract：:Bloom Syndrome (BS) is a human autosomal genetic disorder characterized by a predisposition to a variety of malignant tumors. The gene responsible for BS encodes a protein (BLM) consisting of 1417 amino acids with a nuclear localization signal in the C-terminal region, which is a member of the RecQ helicase family. We...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5387

    authors： Suzuki H,Seki M,Kobayashi T,Kawabe Yi,Kaneko H,Kondo N,Harata M,Mizuno S,Masuko T,Enomoto T

    更新日期：2001-08-17 00:00:00

  • The molecular and functional characterization of E2F-5 transcription factor.

    abstract：:The E2F activity plays a critical role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. We describe here molecular cloning and functional characterization of a fifth member of the E2F family of transcription factors. E2F-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.8010

    authors： Vaishnav YN,Vaishnav MY,Pant V

    更新日期：1998-01-26 00:00:00

  • Properties of a thermoactive beta-1,3-1,4-glucanase (lichenase) from Clostridium thermocellum expressed in Escherichia coli.

    abstract：:A Clostridium thermocellum gene (licB) encoding a thermoactive 1,3-1,4-beta-glucanase (lichenase) with a molecular weight of about 35,000 was localized on a 1.5-kb DNA fragment by cloning and expression in E. coli. The enzyme acts on beta-glucans with alternating beta-1,3- and beta-1,4-linkages such as barley beta-glu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)92004-4

    authors： Schimming S,Schwarz WH,Staudenbauer WL

    更新日期：1991-05-31 00:00:00

  • Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors for vertebrates.

    abstract：:After screening the data base of the Berkeley Drosophila Genome Project with a sequence coding for the transmembrane region of a G protein-coupled receptor, we found that Drosophila might contain a gene coding for a receptor that is structurally related to the Gonadotropin-Releasing Hormone (GnRH) receptors from verte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9230

    authors： Hauser F,Søndergaard L,Grimmelikhuijzen CJ

    更新日期：1998-08-28 00:00:00

  • Metabolism of d-glucose and its pentaacetate ester in muscles and pancreatic islets of GLUT4 null mice.

    abstract：:The metabolism of d-glucose and its pentaacetate ester was investigated in GLUT4 null mice and control C57Bl6/CBA mice. The incorporation of d-[U-(14)C]glucose (1.7 mM) into glycogen of diaphragm, soleus, and extensor digitorium longus muscles averaged, in the GLUT4 null mice, only 34 +/- 7% of the mean corresponding ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1591

    authors： Ladrière L,Charron MJ,Malaisse WJ

    更新日期：1999-11-02 00:00:00

  • SNX1 and SNX2 mediate retrograde transport of Shiga toxin.

    abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.04.159

    authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

    更新日期：2007-06-29 00:00:00

  • Mitochondrial DNA mutation m.3635G>A may be associated with Leber hereditary optic neuropathy in Chinese.

    abstract：:Leber hereditary optic neuropathy (LHON) was the first disease to be linked to the presence of a mitochondrial DNA (mtDNA) mutation. Nowadays over 95% of LHON cases are known to be caused by one of three primary mutations (m.11778G>A, m.14484T>C, and m.3460G>A). Reports for other (rare) primary mutations in LHON patie...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.06.051

    authors： Zhang AM,Zou Y,Guo X,Jia X,Zhang Q,Yao YG

    更新日期：2009-08-21 00:00:00

  • Identification and isolation of endogenous insect phenoloxidase inhibitors.

    abstract：:Inhibitors of phenoloxidase were identified in pupae of the housefly, Musca domestica L. The phenoloxidase inhibitors were purified from final instar pupae of the housefly by a combination of ammonium sulfate fractionation, ion-exchange chromatography, gel filtration and reverse-phase high performance liquid chromatog...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91161-i

    authors： Tsukamoto T,Ichimaru Y,Kanegae N,Watanabe K,Yamaura I,Katsura Y,Funatsu M

    更新日期：1992-04-15 00:00:00

  • Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium.

    abstract：:The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M by 75.3% and at 10(-6) M almost completely. The growth inhibition was accompanied by changes related to proliferation: (1) r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90898-w

    authors： Matsumoto K,Hashimoto K,Nishida Y,Hashiro M,Yoshikawa K

    更新日期：1990-01-30 00:00:00

  • DNA chain unwinding and annealing reactions of lipocortin (annexin) I heterotetramer: regulation by Ca(2+) and Mg(2+).

    abstract：:Lipocortin I-S100 (calcyclin) heterotetramer exhibited ATPase activity in the presence of dsDNA but not ssDNA. To demonstrate its helicase activity, an 80-mer polynucleotide complementary to the replication origin of M13mp18 was synthesized, and the oligonucleotide, (dC)(20), was ligated to either its 5'- or 3'- end f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6422

    authors： Hirata A,Hirata F

    更新日期：2002-02-22 00:00:00

  • Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes.

    abstract：:This study tests the hypothesis that articular chondrocytes shift from a characteristically glycolytic to an oxidative energy metabolism during population expansion in monolayer. Bovine articular chondrocytes were cultured in monolayer under standard incubator conditions for up to 14 days. Cellular proliferation, oxyg...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.06.011

    authors： Heywood HK,Lee DA

    更新日期：2008-08-22 00:00:00

  • Length and sequence polymorphisms in the ribosomal gene spacer of the Hawaiian sea urchin, T. gratilla.

    abstract：:Blot-hybridization of sea urchin (Tripneustes gratilla) genomic DNA with a cloned rDNA probe revealed individual variation in the length of the rDNA repeat unit and also in the non-transcribed spacer sequences. The number of distinct rDNA repeat subclasses distinguishable within any one sea urchin was limited and usua...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91155-1

    authors： Simmen FA,Mandel M,Humphreys T

    更新日期：1986-06-13 00:00:00

  • Quantification by real-time PCR of developmental and adult myosin mRNA in rat muscles.

    abstract：:A real-time RT-PCR assay using newly designed primers was developed to analyze developmental and adult MHC mRNA expression both in skeletal muscles and single fibers. Only 4 ng of total RNA was necessary for the analysis of the relative mRNA expression of MHC genes. Different validation steps were realized concerning ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.11.172

    authors： Sanchez H,Chapot R,Banzet S,Koulmann N,Birot O,Bigard AX,Peinnequin A

    更新日期：2006-02-03 00:00:00

  • Glucose and galactose regulate intestinal absorption of cholesterol.

    abstract：:A dose-dependent increase in cholesterol absorption was induced by glucose addition (0-75 mM) to the apical medium of TC7 cells, a well-characterized clone of Caco-2. The uptake into the cells and the secretion rate to the basolateral space were both enhanced by glucose and galactose. This up-regulation was suppressed...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.150

    authors： Play B,Salvini S,Haikal Z,Charbonnier M,Harbis A,Roussel M,Lairon D,Jourdheuil-Rahmani D

    更新日期：2003-10-17 00:00:00

  • Mono(ADP-ribosyl)ation of Ca2+-dependent ATPase in rabbit skeletal muscle sarcoplasmic reticulum and the effect of poly L-lysine.

    abstract：:We investigated the endogenous mono(ADP-ribosyl)ation of the sarcoplasmic reticulum from rabbit skeletal muscle. The autoradiogram obtained after sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the [adenylate-32P]NAD-treated sarcoplasmic reticulum vesicles revealed a major band corresponding to the MW 105...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80043-8

    authors： Hara N,Mishima K,Tsuchiya M,Tanigawa Y,Shimoyama M

    更新日期：1987-04-29 00:00:00