Inhibition of Sendai virus hemagglutinin neuraminidase by the fusion protein.

Abstract:

:The Sendai virus envelope contains two glycoproteins: the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Inactivation of F causes the loss of fusogenic activity and an increase of the neuraminidase activity of HN. After inactivation of F, HN can be inhibited by fetuin or asialofetuin, as already observed on the water-soluble, C-terminal fragment of HN (Dallocchio, F., Bellini, T., Martuscelli, G., Baiocchi, M., & Tomasi, M. (1991) Biochem. Int. 25, 663-668). Disruption of viral envelopes by detergents does not affect the neuraminidase activity of virions containing inactive F, while it causes an increase of the neuraminidase activity in native virions. Reconstitution of HN into liposomes is accompanied by a decrease of enzymatic activity, due to the random inside-outside distribution of the protein. However, the decrease of the neuraminidase activity is higher in liposomes containing both HN and F. These data suggest that F inhibits the neuraminidase activity of HN.

authors

Dallocchio F,Tomasi M,Bellini T

doi

10.1006/bbrc.1994.1799

subject

Has Abstract

pub_date

1994-06-15 00:00:00

pages

988-93

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71799-2

journal_volume

201

pub_type

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