Inhibition of Sendai virus hemagglutinin neuraminidase by the fusion protein.


:The Sendai virus envelope contains two glycoproteins: the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Inactivation of F causes the loss of fusogenic activity and an increase of the neuraminidase activity of HN. After inactivation of F, HN can be inhibited by fetuin or asialofetuin, as already observed on the water-soluble, C-terminal fragment of HN (Dallocchio, F., Bellini, T., Martuscelli, G., Baiocchi, M., & Tomasi, M. (1991) Biochem. Int. 25, 663-668). Disruption of viral envelopes by detergents does not affect the neuraminidase activity of virions containing inactive F, while it causes an increase of the neuraminidase activity in native virions. Reconstitution of HN into liposomes is accompanied by a decrease of enzymatic activity, due to the random inside-outside distribution of the protein. However, the decrease of the neuraminidase activity is higher in liposomes containing both HN and F. These data suggest that F inhibits the neuraminidase activity of HN.


Dallocchio F,Tomasi M,Bellini T




Has Abstract


1994-06-15 00:00:00














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    journal_title:Biochemical and biophysical research communications

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    authors: Mitani T,Watanabe S,Wada K,Fujii H,Nakamura S,Katayama S

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    journal_title:Biochemical and biophysical research communications

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    authors: Takagi A,Ikeda Y,Kobayashi K,Kobayashi K,Ikeda Y,Kozawa J,Miyauchi H,Li M,Hashimoto C,Hara Y,Yamaguchi S,Suzuki A,Toda T,Nagasaka H,Hirano KI

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  • miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1.

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  • In vitro hydroxylation of bentazon by microsomes from naphthalic anhydride-treated corn shoots.

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    authors: McFadden JJ,Gronwald JW,Eberlein CV

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    journal_title:Biochemical and biophysical research communications

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    journal_title:Biochemical and biophysical research communications

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    journal_title:Biochemical and biophysical research communications

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    journal_title:Biochemical and biophysical research communications

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    journal_title:Biochemical and biophysical research communications

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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