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Extracellular matrix is required for the survival and differentiation of transplanted hepatic progenitor cells.

Abstract：

:Engelbreth-Holm-Swarm (EHS) gel has been reported to maintain the mature hepatocyte phenotypes in primary cultured hepatocytes. We investigated the effect of EHS gel on the differentiation of fetal liver cells, which contain stem/progenitor cells. The isolated fetal liver cells cultured on EHS gel formed a spherical shape and increased liver-specific gene expressions compared with cells cultured on collagen. The hepatic progenitor cells that were transplanted subcutaneously to BALB/c nude mice could survive and express hepatocyte marker alpha-fetoprotein when the cells were suspended with EHS gel. These findings demonstrate that EHS gel supports cytodifferentiation from immature progenitor cells to hepatocytes and maintain its differentiated phenotypes in vitro and in vivo.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tsukada Y,Nagaki M,Suetsugu A,Osawa Y,Moriwaki H

doi

10.1016/j.bbrc.2009.02.158

subject

Has Abstract

pub_date

2009-04-17 00:00:00

pages

733-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00445-8

journal_volume

381

pub_type

杂志文章

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