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Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole.

Abstract：

:Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of carboxypeptidase A by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(C3H4N2)2-4 coordination complexes, providing for the enzyme an anomalous profile of catalytic rate versus imidazole concentration.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mock WL,Wang L

doi

10.1006/bbrc.1999.0440

subject

Has Abstract

pub_date

1999-04-02 00:00:00

pages

239-43

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90440-0

journal_volume

257

pub_type

杂志文章

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