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Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis.

Abstract：

:The mRNA encoding the Type II isozyme of hexokinase was markedly elevated in livers of transgenic mice overexpressing the transcriptionally active nuclear form of sterol regulatory element binding protein-1a (nSREBP-1a), but not in transgenic mice overexpressing the nSREBP-1c or nSREBP-2 isoforms. Cellulose acetate electrophoresis and immunoblotting results confirmed selective increase of the Type II isozyme in livers of transgenic mice expressing nSREBP-1a. SREBP-1a has previously been shown to activate transcription of genes encoding enzymes involved in biosynthesis of fatty acids and glycerolipids and to a lesser extent the enzymes of cholesterol biosynthesis. Thus, these results are consistent with the view that the Type II isozyme serves an anabolic function, providing precursors and reducing equivalents required for increased rates of hepatic lipid synthesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sebastian S,Horton JD,Wilson JE

doi

10.1006/bbrc.2000.2527

subject

Has Abstract

pub_date

2000-04-21 00:00:00

pages

886-91

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)92527-0

journal_volume

270

pub_type

杂志文章

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