当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin.

Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin.

Abstract：

:Extraordinal activation of nigrostriatal and mesolimbic dopaminergic systems (midbrain dopaminergic system) is thought to be one of the most important etiologies for schizophrenia, though the reason why unusual hyperactivation of the dopaminergic system occurs in the schizophrenic brain is quite obscure. Dysbindin, one of the most susceptible genes for schizophrenia, has been reported to be reduced in the schizophrenic brain. In situ hybridization analysis showed the mRNA expression of dysbindin in the mouse substantia nigra. Furthermore, suppression of dysbindin expression in PC12 cells resulted in an increase of the expression of SNAP25, which plays an important role in neurotransmitter release, and increased the release of dopamine. On the other hand, up-regulation of dysbindin expression in PC12 cells showed a tendency to decrease the expression of SNAP25. These data suggest that dysbindin might regulate the dopamine release of the dopaminergic system via modulation of the expression of SNAP25.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kumamoto N,Matsuzaki S,Inoue K,Hattori T,Shimizu S,Hashimoto R,Yamatodani A,Katayama T,Tohyama M

doi

10.1016/j.bbrc.2006.04.163

subject

Has Abstract

pub_date

2006-06-30 00:00:00

pages

904-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00985-5

journal_volume

345

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Macrophage paraoxonase 1 (PON1) binding sites.

    abstract：:Paraoxonase 1 (PON1), an HDL-associated esterase, is known to possess anti-oxidant and anti-atherogenic properties. PON1 was shown to protect macrophages from oxidative stress, to inhibit macrophage cholesterol biosynthesis, and to stimulate HDL-mediated cholesterol efflux from the cells. The aim of the present study ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.106

    authors： Efrat M,Aviram M

    更新日期：2008-11-07 00:00:00

  • S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

    abstract：:Sphingosine 1-phosphate (S1P) induced the inhibition of glioma cell migration. Here, we characterized the signaling mechanisms involved in the inhibitory action by S1P. In human GNS-3314 glioblastoma cells, the S1P-induced inhibition of cell migration was associated with activation of RhoA and suppression of Rac1. The...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.054

    authors： Malchinkhuu E,Sato K,Maehama T,Mogi C,Tomura H,Ishiuchi S,Yoshimoto Y,Kurose H,Okajima F

    更新日期：2008-02-22 00:00:00

  • Genistein inhibits activities of methylenetetrahydrofolate reductase and lactate dehydrogenase, enzymes which use NADH as a substrate.

    abstract：:Genistein (5, 7-dihydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a natural isoflavone revealing many biological activities. Thus, it is considered as a therapeutic compound in as various disorders as cancer, infections and genetic diseases. Here, we demonstrate for the first time that genistein inhibits activi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.08.004

    authors： Grabowski M,Banecki B,Kadziński L,Jakóbkiewicz-Banecka J,Kaźmierkiewicz R,Gabig-Cimińska M,Węgrzyn G,Węgrzyn A,Banecka-Majkutewicz Z

    更新日期：2015-09-25 00:00:00

  • Identification of a rapidly dephosphorylating 95-kDa protein as elongation factor 2 during 8-Br-cAMP treatment of N1E115 neuroblastoma cells.

    abstract：:Treatment of 8-Br-cAMP promotes neurite outgrowth and neuronal differentiation in N1E115 mouse neuroblastoma cells. Prior or simultaneous treatment of PMA blocks 8-Br-cAMP-mediated neurite outgrowth. Phosphorylation of cellular proteins during these treatments was examined in a permeabilized cell system. While PMA pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2754

    authors： Li H,Chen HC,Huang FL

    更新日期：1995-12-05 00:00:00

  • A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA.

    abstract：:A novel inhibitor for the adhesion of monocytes to cytokine-stimulated endothelial cells, K-7174, was selected by an assay system using the cultured human monocytic cells and human endothelial cells. K-7174 inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either tumor necrosis factor a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2784

    authors： Umetani M,Nakao H,Doi T,Iwasaki A,Ohtaka M,Nagoya T,Mataki C,Hamakubo T,Kodama T

    更新日期：2000-06-07 00:00:00

  • Three splicing variants of tomosyn and identification of their syntaxin-binding region.

    abstract：:We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 ami...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0300

    authors： Yokoyama S,Shirataki H,Sakisaka T,Takai Y

    更新日期：1999-03-05 00:00:00

  • hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation.

    abstract：:Kinase suppressor of ras (KSR) and MEKK3 (MAP kinase kinase kinase) are integral members of the MAP kinase pathway. We have recently identified a new isoform of the KSR family named human kinase suppressor of ras-2 (hKSR-2), and demonstrated that hKSR-2 negatively regulates Cot, a MAP3K family member which is importan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.009

    authors： Channavajhala PL,Rao VR,Spaulding V,Lin LL,Zhang YG

    更新日期：2005-09-09 00:00:00

  • Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.

    abstract：:Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous infla...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.016

    authors： Li N,Cao M,Yi S,Cheng J,Wang L,Tao Y,Wu D,Peng J,Zhang M,Qi P,Zhao J

    更新日期：2018-01-08 00:00:00

  • ABCD2 identifies a subclass of peroxisomes in mouse adipose tissue.

    abstract：:ATP-binding cassette transporter D2 (D2) is an ABC half transporter that is thought to promote the transport of very long-chain fatty acyl-CoAs into peroxisomes. Both D2 and peroxisomes increase during adipogenesis. Although peroxisomes are essential to both catabolic and anabolic lipid metabolism, their function, and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.11.046

    authors： Liu X,Liu J,Lester JD,Pijut SS,Graf GA

    更新日期：2015-01-02 00:00:00

  • The appearance of phospholipase activity in the human macrophage-like cell line U937 during dimethyl sulfoxide induced differentiation.

    abstract：:The human histiocyte cell line, U937, with monocyte characteristics, can be induced to differentiate into macrophage-like cells when exposed to growth medium containing 1.5% DMSO. Following three days of exposure, DMSO-treated but not control U937 cells can be stimulated to release endogenous arachidonic acid from the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91089-1

    authors： Myers RF,Siegel MI

    更新日期：1984-01-13 00:00:00

  • Protein half-lives of calmodulin and the plasma membrane Ca-ATPase in rat brain.

    abstract：:We report the half-lives for two proteins involved in the regulation of intracellular calcium in the brain: the plasma membrane Ca-ATPase and its regulatory protein, calmodulin. [14C]-labeled leucine was injected into seven month old adult Fischer 344 rats and the time-dependent appearance and loss of radioactivity wa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7105

    authors： Ferrington DA,Chen X,Krainev AG,Michaelis EK,Bigelow DJ

    更新日期：1997-08-08 00:00:00

  • Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo.

    abstract：:Sepsis-induced muscle proteolysis mainly reflects ubiquitin-proteasome-dependent protein degradation. The effect of in vivo administration of a proteasome inhibitor on muscle protein breakdown during sepsis is not known. We treated rats with the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu-(O-t-butyl)-Ala-leucinal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2398

    authors： Fischer D,Gang G,Pritts T,Hasselgren PO

    更新日期：2000-04-02 00:00:00

  • MgADP activation contributes to force enhancement during fast stretch of isolated skeletal myofibrils.

    abstract：BACKGROUND:When an activated muscle is rapidly stretched, force rises and peaks while muscle lengthens. The peak force is normally called critical-force (Pc). The mechanism behind this increase in force is not well understood, but it has been associated with crossbridges operating in different states. METHODS:Myofibri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.06.070

    authors： Minozzo FC,Altman D,Rassier DE

    更新日期：2015-08-07 00:00:00

  • IL-1 induces expression of WAF1 mRNA in human fibroblasts: mechanisms of accumulation.

    abstract：:WAF1 inhibits cyclin-cyclin dependent kinase complexes, causing arrest in the cell cycle. We report that interleukin-1 (IL-1) regulates the levels of WAF1 protein and mRNA in human fibroblasts. Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2641

    authors： Osawa Y,Hachiya M,Koeffler HP,Suzuki G,Akashi M

    更新日期：1995-11-13 00:00:00

  • The 3-hydroxyacyl-CoA epimerase activity of rat liver peroxisomes is due to the combined actions of two enoyl-CoA hydratases: a revision of the epimerase-dependent pathway of unsaturated fatty acid oxidation.

    abstract：:Chromatography of a rat liver extract on DEAE-cellulose resulted in the near total loss of 3-hydroxyacyl-CoA epimerase activity. The activity was regained either when fractions were recombined or when purified crotonase was added to the early column fractions. A new enoyl-CoA hydratase present in these early fractions...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80098-1

    authors： Smeland TE,Li JX,Chu CH,Cuebas D,Schulz H

    更新日期：1989-05-15 00:00:00

  • Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.

    abstract：:The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum acti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91259-2

    authors： Fujiki H,Tanaka Y,Miyake R,Kikkawa U,Nishizuka Y,Sugimura T

    更新日期：1984-04-30 00:00:00

  • Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor.

    abstract：:The genetic regulation necessary for the formation of a four-chambered heart is tightly regulated by transcription factors such as TBX20, a member of the T-box (TBX) transcription factor family. TBX20 is critical for proper cardiogenesis and is expressed in the heart throughout development. Missense mutations in TBX20...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.020

    authors： Debenedittis P,Harmelink C,Chen Y,Wang Q,Jiao K

    更新日期：2011-06-03 00:00:00

  • Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice.

    abstract：:The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 × JF1 mice and RNA-seq analysis identified Hcn1 gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.145

    authors： Akbor MM,Tomobe K,Yamada T,Kim J,Mano H,Kurosawa N,Sasaki K,Nomura Y,Isobe M

    更新日期：2013-11-08 00:00:00

  • Characterization of contractile endothelin and angiotensin receptors in human resistance arteries: evidence for two endothelin and one angiotensin receptor.

    abstract：:Endothelin-1 (ET-1) and angiotensin II (AII) are potent vasoconstrictor hormones which regulate tissue perfusion and blood pressure. We pharmacologically characterized endothelin and angiotensin receptors mediating contractions of human mammary resistance arteries in myographs for isometric tension recording. ET-1 cau...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2514

    authors： Tschudi MR,Lüscher TF

    更新日期：1994-10-28 00:00:00

  • Classification and interaction modes of 40 rice E2 ubiquitin-conjugating enzymes with 17 rice ARM-U-box E3 ubiquitin ligases.

    abstract：:Rice, a monocot model crop, contains at least 48 putative E2 ubiquitin (Ub)-conjugating enzymes. Based on homology comparisons with 40 Arabidopsis E2 proteins and 35 human E2s, 48 rice E2s were classified into 15 different groups. Yeast two-hybrid analyses using the U-box-domain regions of armadillo (ARM)-U-box E3 Ub-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.01.098

    authors： Bae H,Kim WT

    更新日期：2014-02-21 00:00:00

  • Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity.

    abstract：:C3 is common to all pathways of complement activation augmenting ischemia/reperfusion (I/R)-induced myocardial injury and cardiac dysfunction. Complement inhibition with the complement regulatory protein, C1 inhibitor (C1INH), obviously exerts cardioprotective effects. Here, we examine whether C1INH regulates C3 activ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.09.023

    authors： Fu J,Lin G,Zeng B,Wu Z,Wu Y,Chu H,Qin G,Liang G,Li J,Gan X,Yu X,Li C,Liu D

    更新日期：2006-11-10 00:00:00

  • Computational studies of H5N1 hemagglutinin binding with SA-alpha-2, 3-Gal and SA-alpha-2, 6-Gal.

    abstract：:For influenza H5N1 hemagglutinin, a switch from SA-alpha-2, 3-Gal to SA-alpha-2, 6-Gal receptor specificity is a critical step leading to the conversion from avian-to-human to human-to-human infection. Therefore, the understanding of the binding modes of SA-alpha-2, 3-Gal and SA-alpha-2, 6-Gal to H5N1 hemagglutinin wi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.179

    authors： Li M,Wang B

    更新日期：2006-09-01 00:00:00

  • Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.

    abstract：:Our prior studies showed that certain cobalamins inhibit productive HIV-1 infection of primary cultures of blood lymphocytes and monocytes. We demonstrate here that this antiviral activity may be mediated by an inhibition of HIV-1 integrase, an enzyme required for productive infection. Purified recombinant HIV-1 integ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8629

    authors： Weinberg JB,Shugars DC,Sherman PA,Sauls DL,Fyfe JA

    更新日期：1998-05-19 00:00:00

  • Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.

    abstract：:Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.098

    authors： Jung Y,Kim JC,Park NJ,Bong SK,Lee S,Jegal H,Jin LT,Kim SM,Kim YK,Kim SN

    更新日期：2018-02-05 00:00:00

  • alpha-Difluoromethylornithine does not bind to ornithine decarboxylase-antizyme complex.

    abstract：:alpha-Difluoromethylornithine (DFMO) has been widely used for determining the amounts of ornithine decarboxylase (ODC) in cells. However, we have now found that DFMO does not react with ODC-antizyme complex, indicating that the amounts of radioactive DFMO bound to the protein may not reflect the amounts of ODC in crud...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90338-4

    authors： Kitani T,Fujisawa H

    更新日期：1986-06-30 00:00:00

  • Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts.

    abstract：:We investigated the role of the 27-kDa heat shock protein (HSP27) in cardiac protection using Langendorff-perfused rat hearts. After preconditioning (a single episode of 5 min global ischemia followed by 5 min of reperfusion), HSP27 redistributed from the cytosol to the sarcomere and recovery of the contractile functi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2233

    authors： Sakamoto K,Urushidani T,Nagao T

    更新日期：2000-03-05 00:00:00

  • Inorganic phosphate regulates CryIVA protoxin expression in Bacillus thuringiensis israelensis.

    abstract：:The role of nutritional factors during CryIVA protoxin expression in Bacillus thuringiensis israelensis (Bti) has been investigated. Inorganic phosphate (Pi) was found to stimulate 135 kD protoxin synthesis by Bti cells. There was a corresponding increase in the cryIVA specific mRNA in the presence of Pi. Inorganic ph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1094

    authors： Banerjee-Bhatnagar N

    更新日期：1999-08-27 00:00:00

  • Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates.

    abstract：:Interleukin 12 has demonstrated a wide spectrum of bioactivity on T and NK cells both in vitro and in vivo. Therapeutic potential of these activities has been suggested by studies in murine tumor, viral and microbial models of disease. We have investigated the in vivo effect of rhlL-12 in cynomolgus monkeys treated wi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2583

    authors： Bree AG,Schlerman FJ,Kaviani MD,Hastings RC,Hitz SL,Goldman SJ

    更新日期：1994-11-15 00:00:00

  • Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

    abstract：:Six missense mutations in human cardiac troponin I (cTnI) were recently found to cause restrictive cardiomyopathy (RCM). We have bacterially expressed and purified these human cTnI mutants and examined their functional and structural consequences. Inserting the human cTnI into skinned cardiac muscle fibers showed that...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.10.116

    authors： Yumoto F,Lu QW,Morimoto S,Tanaka H,Kono N,Nagata K,Ojima T,Takahashi-Yanaga F,Miwa Y,Sasaguri T,Nishita K,Tanokura M,Ohtsuki I

    更新日期：2005-12-23 00:00:00

  • LNA-modified oligonucleotides effectively drive intramolecular-stable hairpin to intermolecular-duplex state.

    abstract：:Sequence-specific hybridization of antisense and antigene agent to the target nucleic acid is an important therapeutic strategy to modulate gene expression. However, efficiency of such agents falls due to inherent intramolecular-secondary-structures present in the target that pose competition to intermolecular hybridi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.155

    authors： Kaur H,Wengel J,Maiti S

    更新日期：2007-01-05 00:00:00