当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.

Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.

Abstract：

:Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous inflammatory-related genes that participate in complex biological response of cells to harmful stimuli. Here we studied effects of the KH-type splicing regulatory protein (KSRP), a RNA-binding protein, on innate immune response against H. pylori infection. We found that H. pylori infection downregulated KSRP expression directly, and that KSRP overexpression repressed upregulation of CXCL-2 expression induced by H. pylori and facilitated H. pylori proliferation in vitro. Similarly, KSRP overexpression in H. pylori mice also facilitated H. pylori proliferation and colonization, and induced more severe gastric mucosal damage. Intriguingly, CXCL-2 and HMOX-1 were upregulated in H. pylori infected mice after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori. These results were beneficial for understanding the in vivo function of KSRP on innate immune response against pathogen infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Li N,Cao M,Yi S,Cheng J,Wang L,Tao Y,Wu D,Peng J,Zhang M,Qi P,Zhao J

doi

10.1016/j.bbrc.2017.12.016

subject

Has Abstract

pub_date

2018-01-08 00:00:00

pages

1573-1579

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32401-4

journal_volume

495

pub_type

杂志文章

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