Role of DDX53 in taxol-resistance of cervix cancer cells in vitro.

abstract：:Mutations in the myocilin (MYOC), also known as Trabecular meshwork-Inducible Glucocorticoid Response (TIGR) gene can lead to juvenile open-angle glaucoma in human and may be responsible for at least 3% of primary open-angle glaucoma. To develop a mouse model of primary open angle glaucoma, and to get deeper insight i...

journal_title：Biochemical and biophysical research communications

authors： Tomarev SI,Tamm ER,Chang B

更新日期：1998-04-28 00:00:00

abstract：:Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Despite its generally accepted importance for maintaining tissue homeostasis knowledge about the underlying molecular mechanisms of contact inhibition is still scarce. Since the MAPK ERK1/2 plays a pivotal role in the control of p...

journal_title：Biochemical and biophysical research communications

authors： Küppers M,Faust D,Linz B,Dietrich C

更新日期：2011-03-18 00:00:00

abstract：:Two ATP-competitive inhibitors-4,5,6,7-tetrabromo-benzotriazole (TBBt) and 4,5,6,7-tetrabromo-benzimidazole (TBBz) have been shown to decrease activity of CK2 holoenzyme. Surprisingly it occurs that TBBz contrary to TBBt does not inhibit free catalytic subunit CK2 [Formula: see text]. Both inhibitors are virtually ina...

journal_title：Biochemical and biophysical research communications

authors： Zień P,Abramczyk O,Domańska K,Bretner M,Szyszka R

更新日期：2003-12-19 00:00:00

abstract：:Mitochondrial ATP synthase is responsible for production of the majority of cellular ATP. Disorders of ATP synthase in humans can be caused by numerous mutations in both structural subunits and specific assembly factors. They are associated with variable pathogenicity and clinical phenotypes ranging from mild to the m...

journal_title：Biochemical and biophysical research communications

authors： Nuskova H,Mikesova J,Efimova I,Pecinova A,Pecina P,Drahota Z,Houstek J,Mracek T

更新日期：2020-01-22 00:00:00

abstract：:Three new analogues of trypsin inhibitor CMTI-III were synthesized by the solid-phase method: [Lys5]-CMTI-III, [Orn5]CMTI-III and [Dab5]CMTI-III. Only one analogue with L-lysine residue in position P1 showed inhibitory activity of the same order of magnitude as did wild CMTI-III. Two remaining analogues were completel...

journal_title：Biochemical and biophysical research communications

authors： Jaśkiewicz A,Lesner A,Rózycki J,Rodziewicz S,Rolka K,Ragnarsson U,Kupryszewski G

更新日期：1997-11-26 00:00:00

abstract：:Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts. However, in SK2-/- cells, SK1 expression was markedly increased to SK2 levels whereas in SK1-/- cells, SK2 expression was unaffected. Ceramide, glucosyl...

journal_title：Biochemical and biophysical research communications

authors： Qin J,Kilkus JP,Dawson G

更新日期：2018-06-07 00:00:00

abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

journal_title：Biochemical and biophysical research communications

authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

更新日期：1992-10-15 00:00:00

abstract：:Intracellular symbiotic relationships are prevalent between cnidarians, such as corals and sea anemones, and the photosynthetic dinoflagellate symbionts. However, there is little understanding about how the genes express when the symbiotic relationship is set up. To characterize genes involved in this association, the...

journal_title：Biochemical and biophysical research communications

authors： Kuo J,Chen MC,Lin CH,Fang LS

更新日期：2004-05-21 00:00:00

abstract：:TANC1 and its close relative TANC2 are two important synaptic scaffold proteins which play critical roles in regulating densities of synaptic spines and excitatory synapse strength. Recent studies indicated TANC1 and TANC2 are candidate genes of several neurodevelopmental disorders (NDD). So far, the biochemical prope...

journal_title：Biochemical and biophysical research communications

authors： Yang Q,Liu H,Li Z,Wang Y,Liu W

更新日期：2019-06-25 00:00:00

abstract：:The specificity of the endoglycanase associated with the bacteriophage phi SK1 particles was tested on the native capsular polysaccharide produced by Klebsiella pneumoniae serotype SK1 and on three chemically modified polymers derived from it. The primary structure of the SK1 capsular polysaccharide is: [formula: see ...

journal_title：Biochemical and biophysical research communications

authors： Cescutti P,Paoletti S

更新日期：1994-02-15 00:00:00

abstract：:17α-estradiol is a hormonally inactive isomer of 17β-estradiol, but with similar potency as neuroprotector. However, we have previously reported that pretreatment with high concentration (10 μM) of both estrogens abolishes their neuroprotection in rat cerebellar granule neurons. Here, we have examined neuroprotective ...

journal_title：Biochemical and biophysical research communications

authors： Sørvik IB,Paulsen RE

更新日期：2017-08-26 00:00:00

abstract：:Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circad...

journal_title：Biochemical and biophysical research communications

authors： Oiwa A,Kakizawa T,Miyamoto T,Yamashita K,Jiang W,Takeda T,Suzuki S,Hashizume K

更新日期：2007-02-23 00:00:00

abstract：:AK2 is an adenylate phosphotransferase that localizes at the intermembrane spaces of the mitochondria, and its mutations cause a severe combined immunodeficiency with neutrophil maturation arrest named reticular dysgenesis (RD). Although the dysfunction of hematopoietic stem cells (HSCs) has been implicated, earlier d...

journal_title：Biochemical and biophysical research communications

authors： Oshima K,Saiki N,Tanaka M,Imamura H,Niwa A,Tanimura A,Nagahashi A,Hirayama A,Okita K,Hotta A,Kitayama S,Osawa M,Kaneko S,Watanabe A,Asaka I,Fujibuchi W,Imai K,Yabe H,Kamachi Y,Hara J,Kojima S,Tomita M,Soga T,

更新日期：2018-03-04 00:00:00

abstract：:Osterix (Osx) is a novel zinc finger-containing transcription factor that is essential for osteoblast differentiation and bone formation in bone homeostasis. The mitogen-activated protein (MAP) kinases are a group of evolutionarily conserved proline-directed protein serine/threonine kinases that are activated in respo...

journal_title：Biochemical and biophysical research communications

authors： Choi YH,Gu YM,Oh JW,Lee KY

更新日期：2011-11-25 00:00:00

abstract：:The addition of low concentrations of the chemotactic factor fMet-Leu-Phe to rabbit neutrophils in the absence of cytochalasin B produces very little superoxide. This level of superoxide can be greatly increased in neutrophils pretreated for 30 min with 10 microM of the diacyl-glycerol kinase inhibitor R59022. This po...

journal_title：Biochemical and biophysical research communications

authors： Gomez-Cambronero J,Molski TF,Becker EL,Sha'afi RI

更新日期：1987-10-14 00:00:00

abstract：:Enterovirus 71 (EV71) has led to recent outbreaks of hand, foot and mouth disease (HFMD) in China, resulting in high mortality. In this study, several monoclonal antibodies were generated by immunizing mice with two synthetic peptides, SP55 and SP70, containing amino acids 163-177 and 208-222 of VP1. The specificities...

journal_title：Biochemical and biophysical research communications

authors： Li X,Mao C,Ma S,Wang X,Sun Z,Yi Y,Guo M,Shen X,Sun L,Bi S

更新日期：2009-12-25 00:00:00

abstract：:X-linked Emery-Dreifuss muscular dystrophy is usually caused by absence of the nuclear membrane protein, emerin, due to nonsense mutations or deletions, but a few missense mutations also exist. A pathogenic g993t mutation causes a Q133H change in the nuclear targeting region of emerin, but it may also reduce emerin le...

journal_title：Biochemical and biophysical research communications

authors： Holt I,Clements L,Manilal S,Morris GE

更新日期：2001-10-12 00:00:00

abstract：:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide depende...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

更新日期：1997-08-28 00:00:00

abstract：:Acidic fibroblast growth factors (FGF1s) are heparin binding proteins that regulate a wide array of key cellular processes and are also candidates for promising biomedical applications. FGF1-based therapeutic applications are currently limited due to their inherent thermal instability and susceptibility to proteases. ...

journal_title：Biochemical and biophysical research communications

authors： Kerr R,Agrawal S,Maity S,Koppolu B,Jayanthi S,Suresh Kumar G,Gundampati RK,McNabb DS,Zaharoff DA,Kumar TKS

更新日期：2019-10-15 00:00:00

abstract：:GroEL-like particles of Thermus aquaticus are homo-oligomeric complexes of two stacked seven member rings, sedimenting in the gradient at 20S. The apparent molecular mass of the native particles is 820,000 (+/- 30,000). The protein complex is composed with one polypeptide of M(r) 59,000. Immunoblotting results and N-t...

journal_title：Biochemical and biophysical research communications

authors： Mikulík K,Benada O

更新日期：1993-12-15 00:00:00

abstract：:Lysates of rabbit reticulocytes and other mammalian cells are known to contain an activity which binds with high specificity ppp(A2'p)3A,3'-[32P]pCp. The binding activity shows a marked dependence on preincubation of lysates at different temperatures (4 degrees C - 45 degrees C). For example, binding was increased 50%...

journal_title：Biochemical and biophysical research communications

authors： Wu JM,Eslami B,Semproni AR

更新日期：1983-11-30 00:00:00

abstract：:Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3)...

journal_title：Biochemical and biophysical research communications

authors： Lange S,Lönnroth I,Palm A,Hydén H

更新日期：1985-08-15 00:00:00

abstract：:The polycationic nature of biogenic polyamines such as spermine (SPM, 1) and spermidine (SPD, 2) plays an important role in selective binding to polyanionic nucleic acids. These interactions are mediated by electrostatic and hydrogen bonding forces which led to stabilization of DNA duplexes and triplexes. Transformati...

journal_title：Biochemical and biophysical research communications

authors： Pallan PS,Ganesh KN

更新日期：1996-05-15 00:00:00

abstract：:Subcellular distribution of a novel annexin, annexin XI, was examined in rat tissues. As we have previously reported, annexin XI mainly localizes in nuclei of 3Y1, the rat embryonic fibroblast cell line; however, immunoperoxidase staining was not particularly nuclear in most of the tissues examined in adult rats. Nucl...

journal_title：Biochemical and biophysical research communications

authors： Mamiya N,Iino S,Mizutani A,Kobayashi S,Hidaka H

更新日期：1994-07-15 00:00:00

abstract：:Epidermal 7-ethoxyresorufin O-deethylase (EROD) activity was elevated greater than 100-fold within 4 to 7 h of topical treatment of SENCAR mice with 100 nmol dibenz[a,c]anthracene (DB[a,c]A). Treatment of skin with 2 micrograms of 12-O-tetradecanoylphorbol-13-acetate (TPA) 2 to 8 h prior to DB[a,c]A application suppre...

journal_title：Biochemical and biophysical research communications

authors： Reiners JJ Jr,Cantu AR,Schöller A

更新日期：1992-07-31 00:00:00

abstract：:Sulforaphane, an aliphatic isothiocyanate derived from cruciferous vegetables, is known for its antidiabetic properties. The effects of sulforaphane on lipid metabolism in adipocytes are not clearly understood. Here, we investigated whether sulforaphane stimulates lipolysis. Mature adipocytes were incubated with sulfo...

journal_title：Biochemical and biophysical research communications

authors： Lee JH,Moon MH,Jeong JK,Park YG,Lee YJ,Seol JW,Park SY

更新日期：2012-10-05 00:00:00

abstract：:Dysregulation of microRNAs has been demonstrated to be involved in a variety of biological events related to cancer, including proliferation, metastasis, angiogenesis and immune escape. MiR-616-3p is located on the chromosome region 12q13.3, however, its potential role and clinical implications in gastric cancer remai...

journal_title：Biochemical and biophysical research communications

authors： Wu ZH,Lin C,Liu CC,Jiang WW,Huang MZ,Liu X,Guo WJ

更新日期：2018-07-02 00:00:00

abstract：:Binding of cytochrome b5 to rat cytochrome P450 2B1 was inhibited (by 75%) by a synthetic peptide corresponding to P450 residues 116-134. The role of Lys-122 and Arg-125 were evaluated using peptides in which one or both of these basic residues were replaced with Glu. The Lys-122 substitution nearly abolished while th...

journal_title：Biochemical and biophysical research communications

authors： Omata Y,Sakamoto H,Robinson RC,Pincus MR,Friedman FK

更新日期：1994-06-30 00:00:00

abstract：BACKGROUND:The voltage-gated potassium channel Kv1.5 plays a critical role in the maintenance of the membrane potential. While protein degradation is one of the major mechanisms for the regulation of channel functions, little is known on the degradation mechanism of Kv1.5. METHODS AND RESULTS:Kv1.5 was expressed in CO...

journal_title：Biochemical and biophysical research communications

authors： Kato M,Ogura K,Miake J,Sasaki N,Taniguchi S,Igawa O,Yoshida A,Hoshikawa Y,Murata M,Nanba E,Kurata Y,Kawata Y,Ninomiya H,Morisaki T,Kitakaze M,Hisatome I

更新日期：2005-11-11 00:00:00

abstract：:Self-association of amyloid beta-peptide (Abeta) is considered to be an initial step in the development of Alzheimer's disease and is known to be promoted by negatively charged lipid membranes. We have examined the possibility of non-electrostatic Abeta-membrane interaction by using neutral phosphatidylcholine lipids....

journal_title：Biochemical and biophysical research communications

authors： Yoda M,Miura T,Takeuchi H

更新日期：2008-11-07 00:00:00