当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.

The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.

Abstract：

:Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts. However, in SK2-/- cells, SK1 expression was markedly increased to SK2 levels whereas in SK1-/- cells, SK2 expression was unaffected. Ceramide, glucosylceramide and sphingosine levels were all increased in SK1-/- but less so in SK2-/- cells and S1P levels were not significantly reduced in either SK1-/- or SK2-/- cells. Greatly increased Ceramide glucosyltransferase expression was observed in SK1-/- cells but less so in SK2-/- cells suggested a role in drug resistance. SK2-/- cells grew faster than control and SK1-/-. The cell division gene PCNA was significantly overexpressed in SK2-/- cells, suggesting a cross regulation between SKs and Ceramide glucosyltransferase.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Qin J,Kilkus JP,Dawson G

doi

10.1016/j.bbrc.2018.04.110

subject

Has Abstract

pub_date

2018-06-07 00:00:00

pages

597-602

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30889-1

journal_volume

500

pub_type

杂志文章

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