当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans.

A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans.

Abstract：

:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide dependent 3H-thymidine incorporation, indicating that cPrG.HCl acts as a selective inhibitor of T cell proliferation in the same way as other members of the prodigiosin family. cPrG.HCl inhibited the proliferation of the PMA stimulated Jurkat cells through an apoptotic process. Intriguingly, cPrG.HCl inhibited the H+ translocation by vacuolar type ATPase in chromaffin granule membranes without any effect on either its ATPase activity nor on the membrane conductance of phospholipid bilayers, suggesting that cPrG.HCl selectively uncouples H+ translocation from the ATPase reaction rather than acting as a non-specific ionophore. Since crystalline cPrG.HCl is highly stable, it raises the possibility of its therapeutic use as an immunosuppressant.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

doi

10.1006/bbrc.1997.7186

subject

Has Abstract

pub_date

1997-08-28 00:00:00

pages

543-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97186-2

journal_volume

237

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Characterization of a mutant GLUT4 lacking the N-glycosylation site: studies in transfected rat adipose cells.

    abstract：:GLUT4, the insulin-responsive glucose transporter expressed primarily in muscle and adipose tissue, contains a single N-glycosylation site. We characterized a mutant GLUT4 lacking the N-glycosylation site (Asn57-->Gln) in primary cultures of rat adipose cells. We transiently transfected cells with expression vectors f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0015

    authors： Ing BL,Chen H,Robinson KA,Buse MG,Quon MJ

    更新日期：1996-01-05 00:00:00

  • A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta.

    abstract：:Transforming growth factor-beta (TGF-beta) is crucially virulent in the progression of fibrotic disorders. TAK1 (TGF-beta activated kinase 1) is one of the mitogen-activated kinase kinase kinase (MAPKKK) that is involved in TGF-beta signal transduction. To elucidate the importance of TAK1 in TGF-beta-induced fibrotic ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01207-5

    authors： Ono K,Ohtomo T,Ninomiya-Tsuji J,Tsuchiya M

    更新日期：2003-07-25 00:00:00

  • Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells.

    abstract：:In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence. The time course of the responses, the absolute requireme...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90479-0

    authors： Ohsako S,Deguchi T

    更新日期：1984-07-18 00:00:00

  • Lipoprotein lipase-mediated lipolysis of very low density lipoproteins increases monocyte adhesion to aortic endothelial cells.

    abstract：:Lipoprotein lipase (LPL) bound to vascular endothelial cells hydrolyses triglycerides in plasma lipoproteins. To explore the role of LPL in atherogenesis, the effect of LPL-mediated lipolysis of very low density lipoproteins (VLDL) on monocyte adhesion to endothelial cells was examined. Adhesion of U937 monocytes to p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90267-o

    authors： Saxena U,Kulkarni NM,Ferguson E,Newton RS

    更新日期：1992-12-30 00:00:00

  • Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells by controlling bFGF and PDGF autocrine/paracrine loops.

    abstract：:Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) produced by hepatocellular carcinoma (HCC) cells are responsible for the growth of HCC cells. Accumulating evidence shows that insulin-like growth factor-binding protein-3 (IGFBP-3) suppresses HCC cell proliferation in both IGF-dependent a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.08.059

    authors： Ma Y,Han CC,Li Y,Wang Y,Wei W

    更新日期：2016-09-16 00:00:00

  • mTOR-mediated regulation of translation factors by amino acids.

    abstract：:The mammalian-target-of-rapamycin (mTOR) is a multidomain protein that is important in regulating several components of the translational machinery. mTOR signalling is stimulated by hormones (e.g., insulin) and by amino acids. Our recent data suggest that TOR signalling responds to intracellular amino acids rather tha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2003.07.015

    authors： Proud CG

    更新日期：2004-01-09 00:00:00

  • Distinct atrial natriuretic factor receptor sites on cultured bovine aortic smooth muscle and endothelial cells.

    abstract：:Cultured bovine aortic smooth muscle and endothelial cells each display distinct specific binding sites for radiolabeled atrial natriuretic peptide (ANF). 125I-pro-rANF (103-126)I binding to both cell types is rapid, reversible and competitive. Scatchard plots of the binding data show Bmax values of 5.5 and 0.1 - 2.1 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(85)80179-0

    authors： Schenk DB,Johnson LK,Schwartz K,Sista H,Scarborough RM,Lewicki JA

    更新日期：1985-03-15 00:00:00

  • Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin.

    abstract：:Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were evaluated for effects on stomach and thymus. Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1.33 x 10(-4)mol/kg of ibuprofen caused significant visual irritation score and microscopic thinning, al...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.149

    authors： Downing JE,Madden JC,Ingram MJ,Rostron C

    更新日期：2005-08-26 00:00:00

  • Activin induces the expression of the Xenopus homologue of sonic hedgehog during mesoderm formation in Xenopus explants.

    abstract：:The Xenopus homologue of sonic hedgehog (Xhh) was detected in Xenopus embryos at stages 13 and 31 by RT-PCR, but it was not expressed in explants isolated from the animal hemisphere of Xenopus embryos at stage 8-9. Treatment of the animal cap with activin (1-100 ng/ml) induced the expression of Xhh. However, it was no...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1144

    authors： Yokotal C,Mukasa T,Higashi M,Odaka A,Muroya K,Uchiyama H,Eto Y,Asashima M,Momoi T

    更新日期：1995-02-06 00:00:00

  • Expression analysis for inverted effects of serotonin transporter inactivation.

    abstract：:Inactivation of serotonin transporter (HTT) by pharmacologically in the neonate or genetically increases risk for depression in adulthood, whereas pharmacological inhibition of HTT ameliorates symptoms in depressed patients. The differing role of HTT function during early development and in adult brain plasticity in c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.01.041

    authors： Ichikawa M,Okamura-Oho Y,Shimokawa K,Kondo S,Nakamura S,Yokota H,Himeno R,Lesch KP,Hayashizaki Y

    更新日期：2008-03-28 00:00:00

  • In vivo 13C nuclear magnetic resonance spectroscopy using a solenoid transmit/receiver coil.

    abstract：:Topical nuclear magnetic resonance spectroscopy (NMR) using a solenoid transmit/receiver coil has been used to monitor the kinetics of intragastric utilization of [1-13C] glucose in mice in vivo. Using a double-tuned solenoid coil, signal to noise response was excellent and the natural abundance in vivo 13C spectra ob...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80217-x

    authors： Field J,Irving MG,Brooks WM,Doddrell DM

    更新日期：1984-09-28 00:00:00

  • Neuronal specificity of subtype SQSC1 of squid putative sodium channel.

    abstract：:The distribution of SQSC1 mRNA in tissues of squid Loligo bleekeri was studied by the blot hybridization method. The complete cDNA for the coding region of SQSC1, the invertebrate putative sodium channel, was prepared from squid optic lobe (Sato and Matsumoto, Biochem. Biophys. Res. Comm. 186, 61-68, 1992). Transcript...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1115

    authors： Sato C,Hirota K,Matsumoto G

    更新日期：1995-01-26 00:00:00

  • Identification of one tachykinin- and two kinin-related peptides in the brain of the white shrimp, Penaeus vannamei.

    abstract：:This paper reports the purification of three myotropic neuropeptides from the white shrimp Penaeus vannamei. The central nervous systems of 3500 shrimps were extracted in an acidified solvent, after which four to five HPLC column systems were used to obtain pure peptides. A cockroach hindgut muscle contraction bioassa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8964

    authors： Nieto J,Veelaert D,Derua R,Waelkens E,Cerstiaens A,Coast G,Devreese B,Van Beeumen J,Calderon J,De Loof A,Schoofs L

    更新日期：1998-07-20 00:00:00

  • Studies on the relationship between cell proliferation and cell death: opposite patterns of SGP-2 and ornithine decarboxylase mRNA accumulation in PHA-stimulated human lymphocytes.

    abstract：:To assess the relationship between cell proliferation and cell death, the mRNA accumulation of ornithine decarboxylase (ODC) and sulfated glycoprotein 2 (SGP-2) were measured in human peripheral blood lymphocytes (HPBL) 2-6 hours after stimulation with phytohemagglutinin (PHA). ODC is the rate limiting enzyme of polya...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81254-9

    authors： Grassilli E,Bettuzzi S,Monti D,Ingletti MC,Franceschi C,Corti A

    更新日期：1991-10-15 00:00:00

  • Generation of neutralizing monoclonal antibodies against Enterovirus 71 using synthetic peptides.

    abstract：:Enterovirus 71 (EV71) has led to recent outbreaks of hand, foot and mouth disease (HFMD) in China, resulting in high mortality. In this study, several monoclonal antibodies were generated by immunizing mice with two synthetic peptides, SP55 and SP70, containing amino acids 163-177 and 208-222 of VP1. The specificities...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.09.103

    authors： Li X,Mao C,Ma S,Wang X,Sun Z,Yi Y,Guo M,Shen X,Sun L,Bi S

    更新日期：2009-12-25 00:00:00

  • Genetic manipulation of cardiac Na+/Ca2+ exchange expression.

    abstract：:The Na+/Ca2+ exchanger (NCX) is the primary Ca2+ extrusion mechanism in cardiomyocytes. To further investigate the role of NCX in excitation-contraction coupling and Ca2+ homeostasis, we created murine models with altered expression levels of NCX. Homozygous overexpression of NCX resulted in mild cardiac hypertrophy. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2004.08.038

    authors： Pott C,Goldhaber JI,Philipson KD

    更新日期：2004-10-01 00:00:00

  • Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle.

    abstract：:The natural compound ferulenol, a sesquiterpene prenylated coumarin derivative, was purified from Ferula vesceritensis and its mitochondrial effects were studied. Ferulenol caused inhibition of oxidative phoshorylation. At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide tr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.145

    authors： Lahouel M,Zini R,Zellagui A,Rhouati S,Carrupt PA,Morin D

    更新日期：2007-03-30 00:00:00

  • Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/β-catenin signaling.

    abstract：:Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers and has great potential therapeutic value. We show that tigecycline, a FDA-approved antibiotic drug, targets cervical squamous cell carcinoma through inhibiting Wnt/β-catenin signaling pathway. Tigecycline is effective in in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.09.140

    authors： Li H,Jiao S,Li X,Banu H,Hamal S,Wang X

    更新日期：2015-11-06 00:00:00

  • Expression patterns of connexin 29 (GJE1) in mouse and rat cochlea.

    abstract：:Multiple types of connexin (Cxs) products, including Cx26, Cx30, Cx31, and Cx43, are found by immunolabeling in the mature cochlea. The transcript of Cx29, a newly discovered member of Cx gene family, was also discovered in the cochlea by cDNA macroarray hybridization. However, the functional roles of Cx29 in the coch...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.193

    authors： Yang JJ,Liao PJ,Su CC,Li SY

    更新日期：2005-12-16 00:00:00

  • Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.

    abstract：:The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide bind...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2802

    authors： Vihinen M,Nilsson L,Smith CI

    更新日期：1994-12-15 00:00:00

  • Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.

    abstract：OBJECTIVE:This study aimed to evaluate functions of APOBEC3F gene in biological process of hepatocellular carcinoma (HCC) and anti-tumor mechanisms of bufalin. METHODS:Effect of APOBEC3F and bufalin on cell proliferation and migration abilities were evaluated by CCK-8, wounding healing tests and transwell assays in SK...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.07.169

    authors： Yang Z,Tao Y,Xu X,Cai F,Yu Y,Ma L

    更新日期：2018-09-10 00:00:00

  • The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway.

    abstract：:Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a new promising target for prevention and treatment of cardiac hypertrophy and heart failure. There are three δ isoforms of CaMKII in the heart and previous studies focused primarily on δB and δC types. Here we report the δA isoform of CaMKII is also critically...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.128

    authors： Li C,Cai X,Sun H,Bai T,Zheng X,Zhou XW,Chen X,Gill DL,Li J,Tang XD

    更新日期：2011-05-27 00:00:00

  • Phosphate disruption and metal toxicity in Saccharomyces cerevisiae: effects of RAD23 and the histone chaperone HPC2.

    abstract：:In cells, there exists a delicate balance between accumulation of charged metal cations and abundant anionic complexes such as phosphate. When phosphate metabolism is disrupted, cell-wide spread disturbances in metal homeostasis may ensue. The best example is a yeast pho80 mutant that hyperaccumulates phosphate and as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.01.047

    authors： Rosenfeld L,Culotta VC

    更新日期：2012-02-10 00:00:00

  • Recognition of left-handed Z-DNA of short unmodified oligonucleotides under physiological ionic strength conditions.

    abstract：:The left-handed Z-DNA form of the short unmodified alternating guanine-cytosine oligonucleotides, 5'-(dGdC)(24) and 5'-(dGdC)(18), was selectively detected under physiological ionic strength and pH conditions using the anionic nickel(II) porphyrin, NiTPPS. No spectroscopic signal was observed for NiTPPS with any right...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.05.119

    authors： D'Urso A,Choi JK,Shabbir-Hussain M,Ngwa FN,Lambousis MI,Purrello R,Balaz M

    更新日期：2010-06-25 00:00:00

  • Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells.

    abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.157

    authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

    更新日期：2012-01-13 00:00:00

  • Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum.

    abstract：:Expression of vascular endothelial growth factor (VEGF) by cultured vascular smooth muscle cells was analyzed. Serum and hypoxia had nearly additive actions on VEGF mRNA expression. The function of the VEGF promoter in smooth muscle cells was analyzed using transient luciferase reporter assays. Serum and hypoxia stimu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1947

    authors： D'Angelo G,Ladoux A,Frelin C

    更新日期：2000-01-07 00:00:00

  • Islet cell differentiation in liver by combinatorial expression of transcription factors neurogenin-3, BETA2, and RIPE3b1.

    abstract：:Transcription factors, such as PDX-1, that normally mediate pancreatic development are capable of inducing hepatic progenitor cells to differentiate into cells with pancreatic islet characteristics. We hypothesized that simultaneous expression of multiple transcription factors involved in islet development might enhan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.216

    authors： Song YD,Lee EJ,Yashar P,Pfaff LE,Kim SY,Jameson JL

    更新日期：2007-03-09 00:00:00

  • The mechanism of action of nitric oxide-donating aspirin.

    abstract：:NO-donating aspirin (NO-ASA) is a promising anticancer drug. We studied the contribution of NO-ASA's components (ASA, NO-releasing moiety, and spacer linking them) to its effect. The ASA and NO-releasing moieties play no biological role: ASA inhibits the growth of colon cancer cells >100-fold less potently that NO-ASA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.038

    authors： Kashfi K,Rigas B

    更新日期：2007-07-13 00:00:00

  • Effects of metallic silver particles on resonance energy transfer in labeled bovine serum albumin.

    abstract：:Resonance energy transfer (RET) is widely used to detect proximity between biomolecules. In transparent solution the maximum donor-to-acceptor distance for RET is about 70 A. We measured the effects of metallic silver island films on RET from the intrinsic tryptophan of a protein to a bound probe as the acceptor. Thes...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00555-7

    authors： Malicka J,Gryczynski I,Kusba J,Shen Y,Lakowicz JR

    更新日期：2002-06-21 00:00:00

  • Actin cytoskeletons regulate the stretch-induced increase of Ca2+ current in human gastric myocytes.

    abstract：:Using the whole-cell and single channel recording techniques, the influence of actin cytoskeletons on L-type Ca2+ current was investigated in human gastric smooth muscle cells. In isotonic condition, an actin depolymerizer cytochalasin D (Cyt-D) markedly decreased the whole-cell current (I(Ba)) without changing steady...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.051

    authors： Kim JH,Rhee PL,Kang TM

    更新日期：2007-01-12 00:00:00