Role of cytochrome b5 in catalysis by cytochrome P450 2B4.

abstract：:Cancer-induced pain (CIP) is a kind of chronic pain that occurs during cancer progression over time. However, the mechanisms are largely unknown, and clinical treatment remains challenging. LncRNAs have been reported to play critical roles in various biological processes, including chronic pain. The aim of our study w...

journal_title：Biochemical and biophysical research communications

authors： Sun RM,Wei J,Wang SS,Xu GY,Jiang GQ

更新日期：2020-04-16 00:00:00

abstract：:Earlier, we showed that antibodies specific for human serum albumin are able to bind to erythrocyte-associated albumin and inhibit complement mediated hemolysis. In the present study we determine if inhibition is occurring at the membrane attack phase of complement activation or at an earlier step. We show that althou...

journal_title：Biochemical and biophysical research communications

authors： Houle JJ,Hoffmann EM

更新日期：1994-04-15 00:00:00

abstract：:Sf9 cells infected with the recombinant mouse CaMKII-alpha (Ca2+/calmodulin dependent kinase II) baculovirus expressed 12-15 mg of MCaMKII-alpha per liter of cells. Approximately 50% of the MCaMKII-alpha activity could be purified using a CaM-Sepharose affinity column. The purified MCaMKII-alpha had a M(rapp) of 50 kD...

journal_title：Biochemical and biophysical research communications

authors： Brickey DA,Colbran RJ,Fong YL,Soderling TR

更新日期：1990-12-14 00:00:00

abstract：:The mitogen-activated protein (MAP) kinases mediate the response of renal glomerular mesangial cells to a variety of physiologic and pathologic stimuli. This investigation examines the effect of the cyclopentenone prostaglandin 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2) on MAP kinases in human mesangial cells. ...

journal_title：Biochemical and biophysical research communications

authors： Wilmer WA,Dixon C,Lu L,Hilbelink T,Rovin BH

更新日期：2001-02-16 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the dise...

journal_title：Biochemical and biophysical research communications

authors： Gopalan A,Bhagavat R,Chandra N,Subbarao SH,Raja A,Bethunaickan R

更新日期：2018-02-12 00:00:00

abstract：:Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline)...

journal_title：Biochemical and biophysical research communications

authors： Lopes JC,Botelho FV,Barbosa Silva MJ,Silva SF,Polloni L,Alves Machado PH,Rodrigues de Souza T,Goulart LR,Silva Caldeira PP,Pereira Maia EC,Morelli S,de Oliveira-Júnior RJ

更新日期：2020-12-17 00:00:00

abstract：:Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are limi...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2013-11-01 00:00:00

abstract：:The primary mechanism of imipenem resistance in Pseudomonas aeruginosa has been ascribed to an outer membrane impermeability owing to a loss of expression of protein D2. Attenuated total reflection-Fourier transform infrared spectroscopy in conjunction with statistical methods has been used as a new approach to rapidl...

journal_title：Biochemical and biophysical research communications

authors： Sockalingum GD,Bouhedja W,Pina P,Allouch P,Mandray C,Labia R,Millot JM,Manfait M

更新日期：1997-03-06 00:00:00

abstract：:Altered architecture, composition and quality of the extracellular matrix (ECM) are pathological hallmarks of several inflammatory and fibro-proliferative pathological processes such as osteoarthritis (OA), rheumatoid arthritis (RA), fibrosis and cancer. One of the most important components of the ECM is fibronectin. ...

journal_title：Biochemical and biophysical research communications

authors： Bager CL,Gudmann N,Willumsen N,Leeming DJ,Karsdal MA,Bay-Jensen AC,Høgdall E,Balslev I,He Y

更新日期：2016-09-16 00:00:00

abstract：:Recent studies have demonstrated that adult cells such as pancreatic exocrine cells can be converted to pancreatic β-cells in a process called cell reprogramming. Enteroendocrine cells and β-cells share similar pathways of differentiation during embryonic development. Notably, enteroendocrine K cells express many of t...

journal_title：Biochemical and biophysical research communications

authors： Lee E,Ryu GR,Moon SD,Ko SH,Ahn YB,Song KH

更新日期：2014-01-17 00:00:00

abstract：:The retinoid-related orphan receptor gamma (RORgamma) has been shown to function as a positive regulator of transcription in many cell lines. Transcriptional activation by nuclear receptors involves recruitment of co-activators that interact with receptors through their LXXLL motifs (NR box). In this study, we analyze...

journal_title：Biochemical and biophysical research communications

authors： Kurebayashi S,Nakajima T,Kim SC,Chang CY,McDonnell DP,Renaud JP,Jetten AM

更新日期：2004-03-19 00:00:00

abstract：:The helix-loop-helix protein Id-1 regulates growth and differentiation in many mammalian cells. In human fibroblasts, Id1 and Id1', a putative splicing variant, are cell cycle regulated, essential for proliferation, repressed by senescence, and overexpressed by some tumor cells. To better understand Id1, we determined...

journal_title：Biochemical and biophysical research communications

authors： Nehlin JO,Hara E,Kuo WL,Collins C,Campisi J

更新日期：1997-02-24 00:00:00

abstract：:To understand the role of cysteine (SH) residues in the folding of hen ovalbumin (OVA), SH-mutated OVAs, in which each SH residue was replaced by alanine (C11A, C30A, C367A, and C382A), were prepared. SDS-PAGE analysis under non-reducing conditions showed that the C11A and C30A mutants produced a disulfide (SS) isomer...

journal_title：Biochemical and biophysical research communications

authors： Ishimaru T,Ito K,Tanaka M,Matsudomi N

更新日期：2018-01-01 00:00:00

abstract：:Collagens are the most abundant structural proteins found in the extracellular matrix of vertebrates. Knowledge of the mechanical behavior of collagen monomers is essential for understanding the mechanical properties of collagen fibrils that constitute the main architectural framework of skin, bone, cartilage, and oth...

journal_title：Biochemical and biophysical research communications

authors： Sun YL,Luo ZP,Fertala A,An KN

更新日期：2002-07-12 00:00:00

abstract：:Genomic DNA of the phytopathogenic Erwinia carotovora subsp. carotovora LY34 was partially digested with Sau3AI, ligated into the BamHI site of pBlue-script II SK+, and introduced into E. coli. Two clones that were able to hydrolyse carboxymethylcellulose were selected. 1.5 kb and 1.2 kb fragments containing the celA ...

journal_title：Biochemical and biophysical research communications

authors： Park YW,Lim ST,Cho SJ,Yun HD

更新日期：1997-12-29 00:00:00

abstract：:Recent in vitro and in vivo studies have shown that either animal- or human-derived embryonic stem cells can differentiate into insulin-secreting cells and lower blood glucose levels. However, studies utilizing human umbilical cord blood (HUCB) mononuclear cells to improve blood glucose levels in diabetic animals have...

journal_title：Biochemical and biophysical research communications

authors： Ende N,Chen R,Reddi AS

更新日期：2004-08-13 00:00:00

abstract：:Casein kinase II (CKII) activity in colorectal tumours was compared before and after heterotransplantation onto nude mice. The test revealed that the enzyme activity was about two-fold enhanced in the tumours isolated from the nude mice when compared to the respective primary tumours from which they were derived. Immu...

journal_title：Biochemical and biophysical research communications

authors： Seitz G,Münstermann U,Schneider HR,Issinger OG

更新日期：1989-08-30 00:00:00

abstract：:O-GlcNAcylation is a reversible post-translational modification that regulates cytosolic and nuclear proteins. We and others previously demonstrated that FoxO1 is O-GlcNAcylated in different cell types, resulting in an increase in its transcriptional activity. Four O-GlcNAcylation sites were identified in human FOXO1 ...

journal_title：Biochemical and biophysical research communications

authors： Fardini Y,Perez-Cervera Y,Camoin L,Pagesy P,Lefebvre T,Issad T

更新日期：2015-06-26 00:00:00

abstract：:In rodents, the transcription factors early growth response 2 (EGR2) and sterol regulatory element binding protein 1a (SREBP1a) regulate transcription of the stearoyl-CoA desaturase 2 (SCD2) gene during peripheral nerve myelination, which may be important for synthesis of the lipid component of myelin. Most non-rodent...

journal_title：Biochemical and biophysical research communications

authors： Lengi AJ,Corl BA

更新日期：2012-05-04 00:00:00

abstract：:Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Unfortunately, the mechani...

journal_title：Biochemical and biophysical research communications

authors： Hong X,Li S,Li W,Xie M,Wei Z,Guo H,Wei W,Zhang S

更新日期：2019-01-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a prevalent malignancy with increasing incidence and extremely poor prognosis worldwide. The multi-kinase inhibitor sorafenib is widely used as a first-line systematic treatment agent of advanced hepatocellular carcinoma. However, the benefit of sorafenib in clinical treatment is ofte...

journal_title：Biochemical and biophysical research communications

authors： Long Q,Zou X,Song Y,Duan Z,Liu L

更新日期：2019-06-04 00:00:00

abstract：:Deregulated activation of protein tyrosine kinases, such as the epidermal growth factor receptor (EGFR) and Abl, is associated with human cancers including non-small cell lung cancer (NSCLC) and chronic myeloid leukemia (CML). Although inhibitors of such activated kinases have proved to be of therapeutic benefit in in...

journal_title：Biochemical and biophysical research communications

authors： Ozaki K,Kosugi M,Baba N,Fujio K,Sakamoto T,Kimura S,Tanimura S,Kohno M

更新日期：2010-01-22 00:00:00

abstract：:In order to develop improved synthetic gene transfer vectors, we have synthesized bifunctional peptides composed of a DNA binding peptide (P2) and ligand peptides selected by the phage display technique on tracheal epithelial cells. We have evaluated the capacity of these peptides to enhance the gene transfer efficien...

journal_title：Biochemical and biophysical research communications

authors： Vaysse L,Guillaume C,Burgelin I,Gorry P,Férec C,Arveiler B

更新日期：2002-02-08 00:00:00

abstract：:Cilostazol is a drug licensed for the treatment of intermittent claudication. Its main action is to elevate intracellular levels of cyclic monophosphate (cAMP) by inhibiting the activity of type III phosphodiesterase, a cAMP-degrading enzyme. The effects of cilostazol on fatty acid oxidation (FAO) are as yet unknown. ...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Zhu L,Sui S,Sun C,Jiang H,Ren D

更新日期：2014-05-09 00:00:00

abstract：:Inflammation has been implicated in a variety of psychiatric disorders. We aimed to determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which may reflect activation of the complement system in the brain, are altered in patients with major psychiatric disorders. Additionally, we examined...

journal_title：Biochemical and biophysical research communications

authors： Ishii T,Hattori K,Miyakawa T,Watanabe K,Hidese S,Sasayama D,Ota M,Teraishi T,Hori H,Yoshida S,Nunomura A,Nakagome K,Kunugi H

更新日期：2018-03-04 00:00:00

abstract：:Using an oligonucleotide hybridization assay to gain insight into the folding of delta ribozymes, we demonstrate a correlation between their folding and catalytic behavior. Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J...

journal_title：Biochemical and biophysical research communications

authors： Ananvoranich S,Perreault JP

更新日期：2000-04-13 00:00:00

abstract：:Increasing evidence shows that immune-mediated mechanisms may contribute to the pathogenesis of central nervous system disorders including cerebellar ataxias, as indicated by the aberrant production of neuronal surface antibodies. We previously reported a patient with cerebellar ataxia associated with production of a ...

journal_title：Biochemical and biophysical research communications

authors： Yaguchi H,Yabe I,Takahashi H,Watanabe M,Nomura T,Kano T,Matsumoto M,Nakayama KI,Watanabe M,Hatakeyama S

更新日期：2017-12-09 00:00:00

abstract：:Translational regulation has emerged as an important feature of animal development, especially in the embryo prior to the onset of zygotic transcription. Specialized forms of control regulate the translation of individual mRNAs, and the factors involved in these mRNA-specific events are expected to be found in only a ...

journal_title：Biochemical and biophysical research communications

authors： Lie YS,Macdonald PM

更新日期：2000-04-13 00:00:00

abstract：:Three mRNA species for human muscle phophofructokinase containing heterogeneous 5' untranslated sequences were identified through cDNA cloning. Type A mRNA was essentially the same as that reported previously (Nakajima, H., et al. (1987) FEBS Lett. 223, 113). Type B mRNA was considered to be the major gene product, wh...

journal_title：Biochemical and biophysical research communications

authors： Nakajima H,Yamasaki T,Noguchi T,Tanaka T,Kono N,Tarui S

更新日期：1990-01-30 00:00:00

abstract：:Transthyretin (TTR) is a human disease-associated amyloidogenic protein that has been implicated in senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP). FAP typically results in severe and early-onset disease, and the only therapy established so far is liver transplantation; thus, developin...

journal_title：Biochemical and biophysical research communications

authors： Lee KW,Lee DH,Son H,Kim YS,Park JY,Roh GS,Kim HJ,Kang SS,Cho GJ,Choi WS

更新日期：2009-10-16 00:00:00