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Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates.

Abstract：

:Interleukin 12 has demonstrated a wide spectrum of bioactivity on T and NK cells both in vitro and in vivo. Therapeutic potential of these activities has been suggested by studies in murine tumor, viral and microbial models of disease. We have investigated the in vivo effect of rhlL-12 in cynomolgus monkeys treated with 1 micrograms/kg/day by bolus i.v. or s.c. injection for 5 days. Treated group transient decreases in total WBC counts as compared to controls, with reversable decreases seen mainly in the lymphocyte and monocyte subsets. Phenotypic analysis showed a decrease in the number of CD4+ and CD8+ cells/microL on Days 2 and 4. Reversible thrombocytopenia and anemia were noted in both treated groups as compared to controls. Plasma neopterin concentrations were increased in both treated groups as compared to controls. These data show that rhlL-12 has multiple effects on peripheral hematology and suggests that this model may be useful to investigate in vivo bioactivity of rhlL-12.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Bree AG,Schlerman FJ,Kaviani MD,Hastings RC,Hitz SL,Goldman SJ

doi

10.1006/bbrc.1994.2583

subject

Has Abstract

pub_date

1994-11-15 00:00:00

pages

1150-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72583-6

journal_volume

204

pub_type

杂志文章

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