Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts.

abstract：:Oxidized low-density lipoproteins (LDL) accumulate in the vascular wall and promote a local inflammatory process contributing to the progression of atheromatous plaque. The key role of myeloperoxidase (MPO) in this process has been documented and the enzyme has been involved in the oxidative modification of apolipopro...

journal_title：Biochemical and biophysical research communications

authors： Van Antwerpen P,Boudjeltia KZ,Babar S,Legssyer I,Moreau P,Moguilevsky N,Vanhaeverbeek M,Ducobu J,Nève J

更新日期：2005-11-11 00:00:00

abstract：:Treatment of RGCs with insulin or C2 ceramide alone increased survival rate by 30%. Adding both insulin and C2 ceramide increased survival rate by 80%. Protein phosphatase 2A (PP2A) inhibitor okadaic acid (OA) eliminated the effect of C2 ceramide, but not that of insulin. Protein kinase inhibitor K252a decreased the e...

journal_title：Biochemical and biophysical research communications

authors： Ito M

更新日期：2003-02-07 00:00:00

abstract：:We have identified and characterized insulin receptors on Chinese hamster ovary (CHO) cells. Insulin binds in a time, temperature and pH dependent fashion and insulin analogues compete for 125I-insulin binding in order of their biological potencies. Furthermore, two CHO cell glycosylation mutants, B4-2-1, lacking high...

journal_title：Biochemical and biophysical research communications

authors： Podskalny J,McElduff A,Gorden P

更新日期：1984-11-30 00:00:00

abstract：:The vanilloid receptor type 1 (VR1) is a novel membrane receptor activated by heat or chemical ligands conveying information about chemosensitive and thermosensitive pain. We have overexpressed and purified wild type VR1 (wtVR1) as well as several mutant forms using the yeast strain Saccharomyces cerevisiae with the g...

journal_title：Biochemical and biophysical research communications

authors： Moiseenkova VY,Hellmich HL,Christensen BN

更新日期：2003-10-10 00:00:00

abstract：:Inflammatory processes within the cornea are known to be associated with corneal neovascularization (CN). We examined the effects of inflammatory mediators on the expression of angiogenic factors by corneal cells. TNF-alpha and IL-1 induced VEGF-A secretion by corneal fibroblasts (HCRF) and this was inhibited signific...

journal_title：Biochemical and biophysical research communications

authors： Kommineni VK,Nagineni CN,William A,Detrick B,Hooks JJ

更新日期：2008-09-26 00:00:00

abstract：:Sugars will eventually be exported transporters (SWEETs) are a group of recently identified sugar transporters in plants that play important roles in diverse physiological processes. However, currently, limited information about this gene family is available in pineapple (Ananas comosus). The availability of the recen...

journal_title：Biochemical and biophysical research communications

authors： Guo C,Li H,Xia X,Liu X,Yang L

更新日期：2018-02-05 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are acknowledged as crucial regulators involved in multiple pathological processes, including cancer. Although some lncRNAs are studied in melanoma, the association between lncRNA and melanoma progression still remains vague. And the function of LINC00963 in melanoma is waiting for invest...

journal_title：Biochemical and biophysical research communications

authors： Jiao H,Jiang S,Wang H,Li Y,Zhang W

更新日期：2018-09-26 00:00:00

abstract：:Male Djungarian hamsters (Phodopus sungorus; 45 animals per group) were either sham-exposed or exposed to a sinusoidal magnetic field for 56 days (Experiment 1: 50 Hz, 450 microTesla peak; max. dB/dt = 140 mTesla s(-1); 24 hrs day(-1)). Except for day 7, no effects were observed with respect to body weights during exp...

journal_title：Biochemical and biophysical research communications

authors： Niehaus M,Brüggemeyer H,Behre HM,Lerchl A

更新日期：1997-05-29 00:00:00

abstract：:Unveiling the mechanism of the relapse of acute lymphoblastic leukemia (ALL) is the key to improve the prognosis of ALL and remains a huge challenge. Glycan-based interactions play a vital role in immune surveillance, cell-cell adhesion and cell-matrix interaction, contributing to treatment failure in tumor. However, ...

journal_title：Biochemical and biophysical research communications

authors： Yi L,Hu Q,Zhou J,Liu Z,Li H

更新日期：2019-02-26 00:00:00

abstract：:Immediate-early genes (IEGs) are useful for mapping active brain regions in various vertebrates. Here we identified a c-fos homologue gene in medaka and demonstrated that the amounts of c-fos transcripts and proteins in the medaka brain increased in relation to an artificially evoked seizure, suggesting that the homol...

journal_title：Biochemical and biophysical research communications

authors： Okuyama T,Suehiro Y,Imada H,Shimada A,Naruse K,Takeda H,Kubo T,Takeuchi H

更新日期：2011-01-07 00:00:00

abstract：:Histone-H1 purified from rat skeletal muscle is a relatively potent inhibitor of peptide chain initiation in a cell free system, the rabbit reticulocyte lysate (50% inhibition at approximately 0.4 microM). H1 does not inhibit formation of the ternary complex nor its attachment to 40S ribosomes; the data are compatible...

journal_title：Biochemical and biophysical research communications

authors： O'Leary NE,Cheema IR,Moore K,Mehard WB,Buse MG

更新日期：1987-04-14 00:00:00

abstract：:A common cause for pharmacogenetic alteration in drug response is genetic variation in encoded amino acid sequence. We have used the catecholamine and drug-metabolizing enzyme sulfotransferase (SULT)1A3 to create an artificial model system to study mechanisms-especially possible aggresome formation-by which genetic al...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Yee VC,Weinshilboum RM

更新日期：2004-12-10 00:00:00

abstract：:Release of soluble growth hormone binding protein (GHBP) corresponding to the extracellular domain of the GH receptor (GHR) occurs via distinct mechanisms depending on species. In human, proteolysis of full length GHR results in liberation of GHBP into the extracellular medium. A putative protease responsive for GHR c...

journal_title：Biochemical and biophysical research communications

authors： Conte F,Salles JP,Raynal P,Fernandez L,Molinas C,Tauber M,Bieth E

更新日期：2002-01-18 00:00:00

abstract：:The aggregation state of the gonadotropin receptor has been examined by coupling fluorescence energy transfer donor and acceptor fluorophores to hCG and LH. Energy transfer is observed at low (4 degrees C) but not at high (37 degrees C) temperature. Energy transfer could also be detected with receptor solubilized in t...

journal_title：Biochemical and biophysical research communications

authors： Harmatz D,Ji TH,Middaugh CR

更新日期：1985-03-15 00:00:00

abstract：:A novel protein kinase activity was characterized from the cytosolic fraction of isolated rabbit gastric glands. The kinase phosphorylated a major 33,000 Da endogenous protein (pp33) and was stimulated by Zn2+ and Mn2+ with Kact of 1.0 and 7.5 mM, respectively. Mg2+ and Ca2+ failed to stimulate any pp33 kinase activit...

journal_title：Biochemical and biophysical research communications

authors： Goldenring JR,Oddsdottir M,Modlin IM

更新日期：1987-01-30 00:00:00

abstract：:We report the construction of a cDNA clone encoding a functional GM2-activator protein. The sequence of the complete 5' end of the coding region was determined by direct nucleotide sequencing of a fragment generated by multiple RACE PCR procedures from Hela cell cDNA. Specific oligonucleotides were synthesized from th...

journal_title：Biochemical and biophysical research communications

authors： Xie B,McInnes B,Neote K,Lamhonwah AM,Mahuran D

更新日期：1991-06-28 00:00:00

abstract：:Calmodulin (CaM) was reported to interact with PreIQ and IQ of CaV1.2 channels, but to date, no explicit binding sites of CaM were illustrated. Therefore, in the present study, we firstly used MOE (Molecular Operating Environment) for protein-protein docking and we found that the most likely residues of CaM that play ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Yan S,Chen S,Zhang J,Shen Y,Su J,He G,Feng R,Shao D,Hao L

更新日期：2020-05-21 00:00:00

abstract：:Parenteral immunization of transgenic mouse models of Alzheimer disease (AD) with synthetic amyloid beta-peptide (Abeta) prevented or reduced Abeta deposits and attenuated their memory and learning deficits. A clinical trial of immunization with synthetic Abeta, however, was halted due to brain inflammation, presumabl...

journal_title：Biochemical and biophysical research communications

authors： Fukuchi K,Accavitti-Loper MA,Kim HD,Tahara K,Cao Y,Lewis TL,Caughey RC,Kim H,Lalonde R

更新日期：2006-05-26 00:00:00

abstract：:Malondialdehyde measurements have been the major tool for studying relationships between lipid peroxidation and tissue pathology. Recently, we presented a novel gas chromatography-mass spectrometry method for direct detection of phospholipid peroxides with picogram sensitivity based on transesterification of phospholi...

journal_title：Biochemical and biophysical research communications

authors： van Kuijk FJ,Thomas DW,Stephens RJ,Dratz EA

更新日期：1986-08-29 00:00:00

abstract：:Transcription factors of the nuclear factor-kappa B (NF-κB) family play a pivotal role in inflammation, immunity and cell survival responses. Recent studies revealed that NF-κB also regulates the processes of muscle atrophy. NF-κB activity is regulated by various factors, including ankyrin repeat domain 2 (AnkrD2), wh...

journal_title：Biochemical and biophysical research communications

authors： Liu XH,Bauman WA,Cardozo C

更新日期：2015-08-14 00:00:00

abstract：:alpha-Crystallin, a major eye lens protein, has been shown to function like a molecular chaperone by suppressing the aggregation of other proteins induced by various stress conditions. Ultraviolet (UV) radiation is known to cause structural and functional alterations in the lens macromolecules. Earlier we observed tha...

journal_title：Biochemical and biophysical research communications

authors： Reddy GB,Reddy PY,Suryanarayana P

更新日期：2001-04-06 00:00:00

abstract：:Human natural killer enhancing factor genes (NKEF-A and B) share extensive homology with several genes from other organisms known to be induced by oxidative stress and to protect organisms and proteins from oxidative destruction. In this study, we have identified natural killer enhancing factor as an abundant protein ...

journal_title：Biochemical and biophysical research communications

authors： Shau H,Kim A

更新日期：1994-02-28 00:00:00

abstract：:The DNA segment harboring the promoter region and the exon 1 of the human tyrosinase gene has been cloned and characterized. Sequence analysis reveals the amino-terminal half of tyrosinase molecule including a signal peptide, of which six amino acid residues are not represented in the tyrosinase cDNA, pHT gamma 1 [Shi...

journal_title：Biochemical and biophysical research communications

authors： Takeda A,Tomita Y,Okinaga S,Tagami H,Shibahara S

更新日期：1989-08-15 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2...

journal_title：Biochemical and biophysical research communications

authors： Rudolph MJ,Amodeo GA,Bai Y,Tong L

更新日期：2005-12-02 00:00:00

abstract：:Death-associated protein kinase (DAPk) family has emerged as a novel subfamily of pro-apoptotic serine/threonine kinase in the last 10 years. Although the functions of DAPk have been well documented, those of other family members remain uncertain. In this work, we characterized the expression pattern of human DAPk lik...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Yan Q,Zuo J,Saiyin H,Jiang W,Qiao S,Yu L

更新日期：2010-02-19 00:00:00

abstract：:Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal anti-inflammatory drugs. A functional polymorphism of the CYP2C9 gene has been described. The variant alleles include CYP2C9*2 having a point mutation in exon 3 ca...

journal_title：Biochemical and biophysical research communications

authors： Yasar U,Eliasson E,Dahl ML,Johansson I,Ingelman-Sundberg M,Sjöqvist F

更新日期：1999-01-27 00:00:00

abstract：:In a number of cell lines responsive to basic fibroblast growth factor (bFGF), two major tyrosine phosphorylated proteins, of molecular weights around 120kDa and 90kDa, are precipitated along with the tyrosine phosphatase SHP2 from the lysates of stimulated cells. The docker protein Gab-1 represents at least part of t...

journal_title：Biochemical and biophysical research communications

authors： Ong SH,Lim YP,Low BC,Guy GR

更新日期：1997-09-08 00:00:00

abstract：:There is a major unmet medical need for effective and well tolerated treatment options for cancer. The search now seeks to identify active biomolecules with multiple targets. Lupeol, an important dietary triterpenoid known as anticarcinogen by inducing apoptosis. But it is still more to reveal the potency of lupeol in...

journal_title：Biochemical and biophysical research communications

authors： Vijay Avin BR,Prabhu T,Ramesh CK,Vigneshwaran V,Riaz M,Jayashree K,Prabhakar BT

更新日期：2014-05-30 00:00:00

abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

journal_title：Biochemical and biophysical research communications

authors： Upadhye S,Ananthanarayanan VS

更新日期：1995-10-13 00:00:00

abstract：:A 2.1-kb genomic region responsible for Ogawa serotype specificity of Vibrio cholerae 01 was identified by cosmid cloning and recombinant plasmid experiments. The plasmid carrying this region derived from Ogawa type Vibrio cholerae NIH 41 coded for a specific protein of 27 kD, and was found to convert serotype specifi...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Ohshita Y,Nakamoto T,Hiramatsu K,Yokota T

更新日期：1991-03-15 00:00:00