alpha-Difluoromethylornithine does not bind to ornithine decarboxylase-antizyme complex.

abstract：:Here we studied the effect of molecular crowding on the hydrolysis of ortho- and para-nitrophenyl-β-D-galactopyranosides (ONPG, PNPG) catalysed by Escherichia coli β-Galactosidase in the presence of 0-35%w/v 6kD polyethyleneglycol (PEG6000). The Eadie-Hofstee data analysis exhibited single straight lines for PNPG at a...

journal_title：Biochemical and biophysical research communications

authors： Nolan V,Clop PD,Burgos MI,Perillo MA

更新日期：2019-07-12 00:00:00

abstract：:Although oxygen levels in the extracellular space of most mammalian tissues are just a few percent, under standard cell culture conditions they are not regulated and are often substantially higher. Some cellular sources of reactive oxygen species, like NADPH oxidase 4, are sensitive to oxygen levels in the range betwe...

journal_title：Biochemical and biophysical research communications

authors： Maddalena LA,Selim SM,Fonseca J,Messner H,McGowan S,Stuart JA

更新日期：2017-11-04 00:00:00

abstract：:miR-199b-5p is up-regulated significantly during the osteogenesis process in human bone marrow stromal cells (BMSCs). Inhibiting miR-199b-5p notably reduces while over-expressing miR-199b-5p promotes the BMSCs osteoblast differentiation, suggested by the alternations of osteogenic genes expression, ALP activity and th...

journal_title：Biochemical and biophysical research communications

authors： Zhao R,Li Y,Lin Z,Wan J,Xu C,Zeng Y,Zhu Y

更新日期：2016-09-02 00:00:00

abstract：:We investigated the possible involvement of neuromedin U (NMU) and neuromedin S (NMS) in thermoregulation in rats. Intracerebroventricular (icv) injection of NMU or NMS increased the back surface temperature (BS-T) in a dose-dependent manner during both the light and dark periods. Pre-treatment with the β3 blocker SR5...

journal_title：Biochemical and biophysical research communications

authors： Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

更新日期：2016-02-19 00:00:00

abstract：:Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

journal_title：Biochemical and biophysical research communications

authors： Wolff G,Davidson SJ,Wrobel JK,Toborek M

更新日期：2015-08-07 00:00:00

abstract：:To further elucidate the role of CCAAT/Enhancer Binding Protein alpha (C/EBP alpha) in hepatocyte differentiation, we investigated fetal and newborn C/EBP alpha-deficient (C/EBP alpha -/-) mice using confocal microscopy and markers specific for hepatocyte (AFP) and biliary epithelial cell (A6) differentiation. Histolo...

journal_title：Biochemical and biophysical research communications

authors： Tomizawa M,Garfield S,Factor V,Xanthopoulos KG

更新日期：1998-08-10 00:00:00

abstract：:Plasma high (HDL) and low (LDL) density lipoproteins were isolated from rats fed a diet supplemented with either fish (menhaden) oil or hydrogenated coconut oil (control). Fluorescence polarization and electron spin resonance of labelled fatty acid probe molecules incorporated into the outer amphiphilic monolayer of H...

journal_title：Biochemical and biophysical research communications

authors： Belcher D,Stillwell W,Langsford CA,Wassall SR

更新日期：1988-02-15 00:00:00

abstract：:We have studied the functional properties of an alternately spliced form of sheep testicular FSH receptor cDNA that codes for a protein similar to a previously described active receptor but differs in the carboxy terminus in sequence and is also shorter by 25 residues. The receptor expressed in HEK 293 cells fails to ...

journal_title：Biochemical and biophysical research communications

authors： Sairam MR,Jiang LG,Yarney TA,Khan H

更新日期：1996-09-24 00:00:00

abstract：:The green color of the hemolymph of last instar larvae of the corn earworm, Heliothis zea (Boddie), is caused by the appearance of a blue chromoprotein. This protein (Mr approximately 560,000) is composed of 4 subunits (Mr approximately 150,000). It contains 8.4% lipid and has an equilibrium density of 1.26 g/ml. This...

journal_title：Biochemical and biophysical research communications

authors： Haunerland NH,Bowers WS

更新日期：1986-01-29 00:00:00

abstract：:Several genes are significantly mutated in breast cancer but only a small percentage of mutations are well-known to contribute to cancer development. FASN is involved in de novo lipogenesis and the regulation of ERα signaling. However, the effect of genetic mutations affecting FASN in breast cancer has not thoroughly ...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez-Salinas F,Rojo R,Martinez-Amador C,Herrera-Gamboa J,Trevino V

更新日期：2020-08-20 00:00:00

abstract：:Butyrate, a short-chain fatty acid produced in the colon, as well as its prodrug tributyrin, reduce proliferation and increase differentiation of colon cancer cells. p21(Waf1/Cip1) and p27(Kip1) are negative regulators of cell cycle and are thought to have a key function in the differentiation of various cell lines. W...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Wächtershäuser A,Steinhilber D,Stein J

更新日期：2001-04-27 00:00:00

abstract：:Hypothetical lambda protein ORF314 shows significant homology with the carboxyl end of phage T4 tail-fiber protein gp37. Homology can also be demonstrated between hypothetical lambda protein ORF194 and a fragment of bacteriophage T4 protein gp38. This sequence homology is also reflected in the genomic sequences of the...

journal_title：Biochemical and biophysical research communications

authors： George DG,Yeh LS,Barker WC

更新日期：1983-09-30 00:00:00

abstract：:Previously we found a depression in the activity of hepatic xanthine dehydrogenase in rats fed clofibrate or di(2-ethylhexyl)phthalate. The present study further demonstrated that dietary addition of other peroxisome proliferators, including bezafibrate, dehydroepiandrosterone and perfluoro-n-octanoic acid also depres...

journal_title：Biochemical and biophysical research communications

authors： Satoh A,Sasago S,Takahashi S,Kato N

更新日期：1993-09-15 00:00:00

abstract：:Using a specific radioimmunoassay we have isolated and sequenced a new 45-amino acid peptide from rat atria which exhibits similar physiological and pharmacological properties to rat atrial natriuretic peptide (rANP). We have termed the new peptide iso-rANP, because of its functional and structural similarities to rAN...

journal_title：Biochemical and biophysical research communications

authors： Flynn TG,Brar A,Tremblay L,Sarda I,Lyons C,Jennings DB

更新日期：1989-06-15 00:00:00

abstract：:Helicobacter pylori releases VacA both as free-soluble and as outer membrane vesicle (OMV)-associated toxin. In this study, we investigated the amount of VacA released in each of the two forms and the role of each form in VacA-induced cell vacuolation in vitro. We found that: (1) free-soluble toxin accounted for about...

journal_title：Biochemical and biophysical research communications

authors： Ricci V,Chiozzi V,Necchi V,Oldani A,Romano M,Solcia E,Ventura U

更新日期：2005-11-11 00:00:00

abstract：:Calmodulin contains multiple redox sensitive methionines whose oxidation alters the regulation of numerous targets. Molecular dynamics simulations were used to define the molecular principles that govern how calmodulin is structurally poised to detect and respond to methionine oxidation. We found that calmodulin's ope...

journal_title：Biochemical and biophysical research communications

authors： Walgenbach DG,Gregory AJ,Klein JC

更新日期：2018-10-20 00:00:00

abstract：:Acyl-CoA dehydrogenases (ACADs) are a family of mitochondrial enzymes catalyzing the initial rate-limiting step in the beta-oxidation of fatty acyl-CoA. The reaction provides main source of energy for human heart and skeletal muscle. Eight human ACADs have been described. Deficiency of these enzymes, especially very l...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zhang W,Zou D,Chen G,Wan T,Zhang M,Cao X

更新日期：2002-10-04 00:00:00

abstract：:We earlier reported the mitogenic and immunostimulatory activities of Rhizoctonia bataticola lectin (RBL), purified from phytopathogenic fungus R. bataticola in human PBMC. The lectin demonstrates specificity towards glycoproteins containing complex N-glycans. Since CD45-protein tyrosine phosphatase that abundantly ex...

journal_title：Biochemical and biophysical research communications

authors： Pujari R,Eligar SM,Kumar N,Nagre NN,Inamdar SR,Swamy BM,Shastry P

更新日期：2012-03-23 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in human cerebrospinal fluid (CSF) with dual functions as a prostaglandin D2 (PGD2) synthase and a transporter of lipophilic ligands. Recent studies revealed that L-PGDS plays important roles in protecting against various neuronal di...

journal_title：Biochemical and biophysical research communications

authors： Qin S,Shimamoto S,Maruno T,Kobayashi Y,Kawahara K,Yoshida T,Ohkubo T

更新日期：2015-12-04 00:00:00

abstract：:The Raf kinase inhibitor protein (RKIP) is a tumor suppressor that protects against metastasis and genomic instability. RKIP is downregulated in many types of tumors, although the mechanism for this remains unknown. MicroRNAs silence target genes via translational inhibition or target mRNA degradation, and are thus im...

journal_title：Biochemical and biophysical research communications

authors： Huang L,Dai T,Lin X,Zhao X,Chen X,Wang C,Li X,Shen H,Wang X

更新日期：2012-08-24 00:00:00

abstract：:The anthrax lethal factor (LF) is a Zn(2+)-endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N-terminal region. Much line of effort was carried out to elucidate the catalytic activity of LF for designing the inhibitor and to understand the cellular mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Chai YG,Yoon MY

更新日期：2004-01-02 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of cardiovascular diseases and are modified in response to a variety of stimuli such as bioactive peptides, cytokines and/or grown factors. In this study, we demonstrated that angiotensin II (Ang II) induces a time- and dose-dependent increase...

journal_title：Biochemical and biophysical research communications

authors： Jiménez E,Pérez de la Blanca E,Urso L,González I,Salas J,Montiel M

更新日期：2009-03-20 00:00:00

abstract：:We have reported that the principal neutralizing domain of V3 of the HIV-1 gp120 induces an antigen-specific activation apoptosis of responding effector CD4+ T lymphocytes, a phenomenon inhibited by RANTES, an agonist of CCR5. Here, addressing the question of how a hypervariable region could induce such a selective re...

journal_title：Biochemical and biophysical research communications

authors： Baritaki S,Zafiropoulos A,Sioumpara M,Politis M,Spandidos DA,Krambovitis E

更新日期：2002-11-08 00:00:00

abstract：:The aim of this study was to investigate the effect of fluctuations in blood glucose levels on atherogenesis. Apolipoprotein (apo) E-deficient mice fed maltose twice daily were used as a model of repetitive postprandial glucose spikes. We investigated the number of macrophages adherent to the endothelium and the area ...

journal_title：Biochemical and biophysical research communications

authors： Mita T,Otsuka A,Azuma K,Uchida T,Ogihara T,Fujitani Y,Hirose T,Mitsumata M,Kawamori R,Watada H

更新日期：2007-07-06 00:00:00

abstract：:Recent progress in the field of mesenchymal stem cell (MSC) biology has enabled their clinical application. In the autologous cell transplantation therapy, the source of MSCs are quite important to reduce patients' physical burden. In this study, we isolated MSCs from the synovial fluid (SF) and synovial membrane (Syn...

journal_title：Biochemical and biophysical research communications

authors： Amemiya M,Tsuji K,Katagiri H,Miyatake K,Nakagawa Y,Sekiya I,Muneta T,Koga H

更新日期：2020-03-05 00:00:00

abstract：:Mutations of the mitochondria DNA (mtDNA) displacement loop (D-loop) were investigated to clarify different changes of exogenous and endogenous liver carcinogenesis in rats. We induced hepatocellular carcinomas (HCCs) in rats with N-nitrosodiethylamine (DEN) and a choline-deficient l-amino acid-defined (CDAA) diet. DN...

journal_title：Biochemical and biophysical research communications

authors： Onishi M,Sokuza Y,Nishikawa T,Mori C,Uwataki K,Honoki K,Tsujiuchi T

更新日期：2007-10-12 00:00:00

abstract：:The specific binding of leukotriene B4 to its receptor on human leukocyte membranes was enhanced in a dose-dependent manner by metal ions. Mg2+ and Ca2+ were the most potent followed by Mn2+ and Co2+. These divalent cations increased receptor density and did not affect the binding affinity. Addition of the same divale...

journal_title：Biochemical and biophysical research communications

authors： Ng CF,Haeggström JZ,Samuelsson B

更新日期：1997-07-18 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] initiates the hydrolysis of sphingomyelin in ROS 17/2.8 osteosarcoma cells with the resultant generation of cell-associated ceramide. Increases in ceramide levels were detectable at 15 min and maximal one hour after exposure of cells to 1,25(OH)(2)D(3). Neither 1,25(OH)(2)D...

journal_title：Biochemical and biophysical research communications

authors： Liu R,Xu Y,Farach-Carson MC,Vogel JJ,Karin NJ

更新日期：2000-06-24 00:00:00

abstract：:Incubation with protein kinase NII did not result in phosphorylation or inactivation of mouse kidney ornithine decarboxylase. Partially purified ornithine decarboxylase preparations contained a protein kinase activity and stimulated the activity of RNA polymerase I. However, these properties were due to contaminating ...

journal_title：Biochemical and biophysical research communications

authors： Seely JE,Stetler DA,Jacob ST,Pegg AE

更新日期：1984-04-16 00:00:00

abstract：:Norepinephrine (NE) modulates brain functions depending on both the internal and external environment. While the neuromodulatory actions of NE have been well characterized, the response and involvement of cortical astrocytes to physiological noradrenergic systems remain largely unknown, especially at the molecular lev...

journal_title：Biochemical and biophysical research communications

authors： Nuriya M,Morita A,Shinotsuka T,Yamada T,Yasui M

更新日期：2018-10-12 00:00:00