IL-1 induces expression of WAF1 mRNA in human fibroblasts: mechanisms of accumulation.

abstract：:The present study was undertaken to evaluate the functional significance of the previously observed increase in the level of IGF-II receptors despite the loss of growth promoting activity of IGF-II in differentiated limb buds in organ culture. In the present study IGF-II and insulin at similar concentration (0.1-1 mic...

journal_title：Biochemical and biophysical research communications

authors： Bhaumick B,Bala RM

更新日期：1988-04-15 00:00:00

abstract：:l-Aspartyl (l-Asp) and l-asparaginyl residues in proteins isomerize or racemize to d,l-isoaspartyl (d,l-isoAsp) or d-aspartyl (d-Asp) residues during protein aging. These atypical aspartyl residues can interfere with the biological function of the protein and lead to cellular dysfunction. Protein l-isoaspartyl (d-aspa...

journal_title：Biochemical and biophysical research communications

authors： Kosugi S,Furuchi T,Katane M,Sekine M,Shirasawa T,Homma H

更新日期：2008-06-20 00:00:00

abstract：:Iron administration to HeLa cells stimulates the accumulation of H-subunit and L-subunit rich isoferritins at similar extent. The increase in both types of isoferritins is accompanied by an increase in the amount of messenger RNAs specific for H and L subunits. The increase in the amount of these messenger RNAs, which...

journal_title：Biochemical and biophysical research communications

authors： Cairo G,Bardella L,Schiaffonati L,Arosio P,Levi S,Bernelli-Zazzera A

更新日期：1985-11-27 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n=6), low dose IL-6 (LoIL-6; n=6), or saline (CON; n=6) infused into one femoral artery for 3h. Muscle biopsies were obtained from t...

journal_title：Biochemical and biophysical research communications

authors： Febbraio MA,Steensberg A,Fischer CP,Keller C,Hiscock N,Pedersen BK

更新日期：2002-09-06 00:00:00

abstract：:Firefly luciferase is inactivated by singlet oxygen at near diffusion controlled rates, 1.9 X 10(9) M-1 s-1, based on direct comparison with the oxidation of L-histidine. The inactivation kinetics are multiphasic. Inactivation is inhibitable by NaN3. Surface-separated-sensitizer (SSS) system in which singlet oxygen is...

journal_title：Biochemical and biophysical research communications

authors： Thompson A,Nigro J,Seliger HH

更新日期：1986-11-14 00:00:00

abstract：:The conformation of lens crystallins in vivo or in a highly concentrated solution is not well established. Most studies were carried out in dilute solutions in which protein-protein interaction is minimal. In order to see whether there is conformational change (tertiary and secondary structures) when crystallin soluti...

journal_title：Biochemical and biophysical research communications

authors： Liang JJ,Chakrabarti B

更新日期：1998-05-19 00:00:00

abstract：:Peroxynitrite, formed by the interaction of superoxide with nitric oxide, has previously been implicated mostly as a cytotoxic agent. In contrast, its physiological and, possibly, beneficial effects are largely unknown. We have previously shown [Journal of Biological Chemistry, 1997, 272, 7253] that RAW 264.7 macropha...

journal_title：Biochemical and biophysical research communications

authors： Scivittaro V,Boggs S,Mohr S,Lapetina EG

更新日期：1997-12-08 00:00:00

abstract：:The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic manner. Blebbing cells transformed cell morphology...

journal_title：Biochemical and biophysical research communications

authors： Bang J,Jang M,Huh JH,Na JW,Shim M,Carlson BA,Tobe R,Tsuji PA,Gladyshev VN,Hatfield DL,Lee BJ

更新日期：2015-01-24 00:00:00

abstract：:A L-delta 1-pyrroline-5-carboxylate reductase activity has been detected in crude extracts of Desulfovibrio desulfuricans Norway. This P5C reductase activity is also found when a 2.5 kb D. desulfuricans DNA fragment is introduced into an Escherichia coli proC mutant. Although it restores growth of the proC mutant, the...

journal_title：Biochemical and biophysical research communications

authors： Fons M,Cami B,Chippaux M

更新日期：1991-09-16 00:00:00

abstract：:Two novel allergens, designated Mal f 2 and Mal f 3 according to the WHO/IUIS Allergen Nomenclature Subcommittee recommendation, were isolated from the lipophilic yeast Malassezia furfur cell extracts and the genes coding for those were cloned. Mal f 2 and Mal f 3 had apparent molecular weights of 21 kDa and 20 kDa, r...

journal_title：Biochemical and biophysical research communications

authors： Yasueda H,Hashida-Okado T,Saito A,Uchida K,Kuroda M,Onishi Y,Takahashi K,Yamaguchi H,Takesako K,Akiyama K

更新日期：1998-07-20 00:00:00

abstract：:Runt-related transcription factor-2 (RUNX2)/core binding factor a1 (Cbfa1) is implicated in the regulation of osteoblast differentiation and osteoblast-specific gene expression. Mutations in RUNX2 cause the bone disease cleidocranial dysplasia, which is characterized by multiple skeletal defects. RUNX2 is expressed as...

journal_title：Biochemical and biophysical research communications

authors： Sudhakar S,Li Y,Katz MS,Elango N

更新日期：2001-11-30 00:00:00

abstract：:By alignment to the carboxy-terminal-deduced aa sequence of human cytomegalovirus glycoprotein B (gB), conserved hexameric aa motifs with putative function for localization in the inner nuclear membrane (INM) were identified in the nucleoplasmic tails of herpes simplex virus type 1 gB and of the cellular lamin B recep...

journal_title：Biochemical and biophysical research communications

authors： Meyer G,Gicklhorn D,Strive T,Radsak K,Eickmann M

更新日期：2002-03-08 00:00:00

abstract：:Concanavalin A (ConA), a Ca(2+)/Mn(2+)-dependent and mannose/glucose-binding legume lectin, has drawn a rising attention for its remarkable anti-proliferative and anti-tumor activities to a variety of cancer cells. ConA induces programmed cell death via mitochondria-mediated, P73-Foxo1a-Bim apoptosis and BNIP3-mediate...

journal_title：Biochemical and biophysical research communications

authors： Li WW,Yu JY,Xu HL,Bao JK

更新日期：2011-10-22 00:00:00

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:Hepatitis B virus infection is primarily mediated by the interaction of the preS region of the viral envelope protein with its still unknown cellular receptor. Using recombinantly expressed preS proteins, the distribution of preS-binding receptors on cell lines from extrahepatic origins was determined by immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Choi EA,Cho EW,Lee YJ,Park JM,Na SY,Kim KL

更新日期：2000-10-14 00:00:00

abstract：:The mRNA of the mitochondrial uncoupling protein 2 (UCP2) was up-regulated by cryptorchidism, a testicular hyperthermic condition under which germ cells undergo severe apoptosis. We investigated whether UCP2 was able to protect germ cells from hyperthermia-induced apoptosis. UCP2 was predominantly present in elongate ...

journal_title：Biochemical and biophysical research communications

authors： Zhang K,Shang Y,Liao S,Zhang W,Nian H,Liu Y,Chen Q,Han C

更新日期：2007-08-24 00:00:00

abstract：:The thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6, assimilates carbon dioxide via the reductive tricarboxylic acid cycle. A gene cluster, porEDABG, encoding pyruvate:ferredoxin oxidoreductase (POR), which plays a key role in this cycle, was cloned and se...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Ochiai T,Morita S,Nishiyama A,Yamada E,Arai H,Ishii M,Igarashi Y

更新日期：2006-02-03 00:00:00

abstract：:There are very few reports on antifungal proteins from rhizomes and there is none from the family of Zingiberaceae. An antifungal protein with a novel N-terminal sequence was isolated from ginger rhizomes utilizing a protocol that involved ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Ng TB

更新日期：2005-10-14 00:00:00

abstract：:The rat pancreatic acinar cell line AR 4-2J is endowed with numerous PACAP type I receptors (PACAPR1). The cDNA of this receptor was PCR amplified at low stringency using two degenerate primers based on conserved sequences in the TM2 and TM6 segments of secretin, parathormone and calcitonin receptors. One additional a...

journal_title：Biochemical and biophysical research communications

authors： Svoboda M,Tastenoy M,Ciccarelli E,Stiévenart M,Christophe J

更新日期：1993-09-15 00:00:00

abstract：:Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein. The relationship between NPM and p53 in the central nervous system (CNS) remains unknown. Here, ...

journal_title：Biochemical and biophysical research communications

authors： Marquez-Lona EM,Tan Z,Schreiber SS

更新日期：2012-01-06 00:00:00

abstract：:We have investigated the subcellular localization of the inwardly rectifying K+ channel subunit Kir6.1 (uKATP-1). Immunoblot analysis of the mitochondrial fractions prepared from rat skeletal muscle and liver detected a single band of Kir6.1 at 51 kDa, the intensity of which was stronger than that found in the total h...

journal_title：Biochemical and biophysical research communications

authors： Suzuki M,Kotake K,Fujikura K,Inagaki N,Suzuki T,Gonoi T,Seino S,Takata K

更新日期：1997-12-29 00:00:00

abstract：:Adsorption of phage T4 to its outer membrane receptor (the lipopolysaccharide) triggers a transient depolarization of the cytoplasmic membrane which is prevented upon addition of EGTA, suggesting that calcium is necessary for the transmission of the signal between the two membranes. Using the fluorescent indicator QUI...

journal_title：Biochemical and biophysical research communications

authors： Boulanger P,Labedan B,Letellier L

更新日期：1985-09-16 00:00:00

abstract：:The methylcoenzyme M methylreductase reaction has an absolute requirement for 7-mercaptoheptanoylthreonine phosphate or component B, which is the active component of the intact molecule previously referred to as cytoplasmic cofactor. A hydrolytic fragment of cytoplasmic cofactor has been purified and identified as uri...

journal_title：Biochemical and biophysical research communications

authors： Marsden BJ,Sauer FD,Blackwell BA,Kramer JK

更新日期：1989-03-31 00:00:00

abstract：:The mouse gene locus Lsh/Ity/Bcg regulates macrophage activation for antimicrobial activity against intracellular pathogens. A candidate gene, designated natural resistance-associated macrophage protein gene (Nramp), recently isolated from a mouse pre-B cell cDNA library, encodes an integral membrane protein that has ...

journal_title：Biochemical and biophysical research communications

authors： Kishi F

更新日期：1994-11-15 00:00:00

abstract：:Glucose transporter-1 (GLUT1) is important in placental glucose transport. However, the mechanism of regulation of placental GLUT1 expression remains to be elucidated. We show here that the level of GLUT1 protein in rat choriocarcinoma cells (Rcho-1) decreased during differentiation. To analyze the regulatory mechanis...

journal_title：Biochemical and biophysical research communications

authors： Okamoto Y,Sakata M,Yamamoto T,Nishio Y,Adachi K,Ogura K,Yamaguchi M,Takeda T,Tasaka K,Murata Y

更新日期：2001-11-09 00:00:00

abstract：:Ca2+ influx from the extracellular space in nonexcitable cells occurs via receptor-operated and refilling processes. However, they showed different characteristics with respect to the Mn2+ permeability, depletion of intracellular Ca2+ stores, and sensitivity to the K+ ionophore valinomycin in rat pancreatic acinar cel...

journal_title：Biochemical and biophysical research communications

authors： Tsunoda Y,Tashiro Y

更新日期：1999-03-24 00:00:00

abstract：:In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led us to identify a 984 base pair open reading frame encoding a new human P2Y receptor. It appeared later that this sequence c...

journal_title：Biochemical and biophysical research communications

authors： Communi D,Parmentier M,Boeynaems JM

更新日期：1996-05-15 00:00:00

abstract：:Evaluation of analogs of the blocked insect myotropic neuropeptide leucopyrokinin (LPK) has demonstrated its relative insensitivity to amino acid substitution in the N-terminal in contrast to the C-terminal region. Truncated analogs of LPK without the first, second, and third N-terminal amino acids retain a significan...

journal_title：Biochemical and biophysical research communications

authors： Nachman RJ,Holman GM,Cook BJ

更新日期：1986-06-30 00:00:00

abstract：:Lampreys are one of the most primitive vertebrates diverged some 500 million years ago. It has long been known that parasitic lampreys secrete anticoagulant from their buccal glands and prevent blood coagulation of host fishes. We found two major protein components of 160 and 26 kDa in the buccal gland secretion of pa...

journal_title：Biochemical and biophysical research communications

authors： Ito N,Mita M,Takahashi Y,Matsushima A,Watanabe YG,Hirano S,Odani S

更新日期：2007-06-22 00:00:00

abstract：:The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. ...

journal_title：Biochemical and biophysical research communications

authors： Bruzzone S,Battaglia F,Mannino E,Parodi A,Fruscione F,Basile G,Salis A,Sturla L,Negrini S,Kalli F,Stringara S,Filaci G,Zocchi E,Fenoglio D

更新日期：2012-05-25 00:00:00