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Nucleolar stress characterized by downregulation of nucleophosmin: a novel cause of neuronal degeneration.

Abstract：

:Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein. The relationship between NPM and p53 in the central nervous system (CNS) remains unknown. Here, we assessed the role of NPM in the CNS using a model of seizure-induced neurodegeneration. We show that NPM overexpression is neuroprotective against kainic acid-induced excitotoxicity, and that downregulation of NPM is pro-apoptotic in a p53-independent manner. These results suggest a key role for NPM in promoting neuronal survival and a novel mechanism of neuronal degeneration triggered by nucleolar stress.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Marquez-Lona EM,Tan Z,Schreiber SS

doi

10.1016/j.bbrc.2011.11.152

subject

Has Abstract

pub_date

2012-01-06 00:00:00

pages

514-20

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)02193-0

journal_volume

417

pub_type

杂志文章

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