Lyso(bis)phosphatidic acid: a novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages.

abstract：:Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac...

journal_title：Biochemical and biophysical research communications

authors： Ogura Y,Iemitsu M,Naito H,Kakigi R,Kakehashi C,Maeda S,Akema T

更新日期：2011-11-04 00:00:00

abstract：:Neurodegeneration causes dysfunction and degeneration of neurons and is triggered by various factors including genetic defects, free radicals, injury, and glutamate excitotoxicity. Among those, glutamate excitotoxicity is implicated in chronic disorders including AD and ALS, and in acute insults in the CNS including t...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara T,Morimoto K

更新日期：2013-10-25 00:00:00

abstract：:Kruppel-like factor 2 (KLF2) is a crucial anti-angiogenic factor. However, its precise role in hepatic angiogenesis induced by liver sinusoidal endothelial cells (LSECs) remain unclear. This study was aimed to evaluate the effect of KLF2 on angiogenesis of LSECs and to explore the corresponding mechanism. Cultured hum...

journal_title：Biochemical and biophysical research communications

authors： Zeng XQ,Li N,Pan DY,Miao Q,Ma GF,Liu YM,Tseng YJ,Li F,Xu LL,Chen SY

更新日期：2015-09-04 00:00:00

abstract：:The function of His159 in the enolase mechanism is disputed. Recently, Vinarov and Nowak (Biochemistry (1999) 38, 12138-12149) prepared the H159A mutant of yeast enolase 1 and expressed this in Escherichia coli. They reported minimal (ca. 0.01% of the native value) activity, though the protein appeared to be correctly...

journal_title：Biochemical and biophysical research communications

authors： Brewer JM,Holland MJ,Lebioda L

更新日期：2000-10-05 00:00:00

abstract：:The chemical industry has come under increasing pressure to make chemical production more eco-friendly and independent to fossil resources. The development of industrial processes based on micro-organisms can especially help to eliminate the use or the generation of hazardous substances and can support the transition ...

journal_title：Biochemical and biophysical research communications

authors： Saibi W,Abdeljalil S,Masmoudi K,Gargouri A

更新日期：2012-09-28 00:00:00

abstract：:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide depende...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

更新日期：1997-08-28 00:00:00

abstract：:Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with ga...

journal_title：Biochemical and biophysical research communications

authors： Zhang B,Rong G,Wei H,Zhang M,Bi J,Ma L,Xue X,Wei G,Liu X,Fang G

更新日期：2008-09-26 00:00:00

abstract：:In eukaryotes, LAMMER kinases are involved in various cellular events, including the cell cycle. However, no attempt has been made to investigate the mechanisms that underlie the involvement of LAMMER kinase. In this study, we performed a functional analysis of LAMMER kinase using the fission yeast, Schizosaccharomyce...

journal_title：Biochemical and biophysical research communications

authors： Yu EY,Lee JH,Kang WH,Park YH,Kim L,Park HM

更新日期：2013-03-01 00:00:00

abstract：:Homocysteine thiolactone is a highly reactive homocysteine derivative that can react easily with proteins. Protein homocysteinylation has been suggested as a possible mechanism underlying the pathological consequences of impaired homocysteine metabolism. Homocysteine inhibits key steps of angiogenesis and tumor invasi...

journal_title：Biochemical and biophysical research communications

authors： Martínez-Poveda B,Chavarría T,Sánchez-Jiménez F,Quesada AR,Medina MA

更新日期：2003-11-21 00:00:00

abstract：:The addition of low concentrations of the chemotactic factor fMet-Leu-Phe to rabbit neutrophils in the absence of cytochalasin B produces very little superoxide. This level of superoxide can be greatly increased in neutrophils pretreated for 30 min with 10 microM of the diacyl-glycerol kinase inhibitor R59022. This po...

journal_title：Biochemical and biophysical research communications

authors： Gomez-Cambronero J,Molski TF,Becker EL,Sha'afi RI

更新日期：1987-10-14 00:00:00

abstract：:The mammalian dorsal cochlear nucleus (DCN) is considered to contribute to the localization of the sound sources. Fusiform cells (FCs), principal projection neurons in the DCN, integrate two excitatory inputs from auditory nerve fibers (ANFs) and parallel fibers (PFs). Although an immunohistochemical study suggested p...

journal_title：Biochemical and biophysical research communications

authors： Irie T,Ohmori H

更新日期：2008-03-07 00:00:00

abstract：:The rat Bone/Liver/kidney/Placenta Alkaline Phosphatase (ALP) is transcribed from two alternative promoters spaced over 25 kb apart, resulting in two variant transcripts that are identical in their coding sequence. We investigated the steady-state levels of the two variant transcripts in various rat tissues and cell l...

journal_title：Biochemical and biophysical research communications

authors： Zernik J,Kream B,Twarog K

更新日期：1991-05-15 00:00:00

abstract：:Isocitrate dehydrogenase 1 (IDH1) mutations have been detected in gliomas and other tumors. Although IDH1 catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in cytosol, mutated IDH1 proteins possess the ability to change α-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Several mono...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Ogasawara S,Oki H,Liu X,Kaneko MK,Takano S,Kato Y

更新日期：2015-10-30 00:00:00

abstract：:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It wa...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

更新日期：2009-07-31 00:00:00

abstract：:Neurodegenerative diseases are characterized by distinctive neuropathological alterations, including the cerebral accumulation of misfolded protein aggregates, neuroinflammation, synaptic dysfunction, and neuronal loss, along with behavioral impairments. Traumatic brain injury (TBI) is believed to be an important risk...

journal_title：Biochemical and biophysical research communications

authors： Edwards G 3rd,Moreno-Gonzalez I,Soto C

更新日期：2017-02-19 00:00:00

abstract：:ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Yamagata T,Takahashi T,Honda H,Hirai H

更新日期：1999-07-05 00:00:00

abstract：:It is well recognized that phorbol 12,13-dibutyrate (PDBu)-activated PKC directly phosphorylates myristoylated alanine-rich C kinase substrate (MARCKS), whose phosphorylation is used as a marker of PKC activation. However, in SH-SY5Y neuroblastoma cells, Western blotting analyses revealed that Rho-associated coiled-co...

journal_title：Biochemical and biophysical research communications

authors： Tanabe A,Kamisuki Y,Hidaka H,Suzuki M,Negishi M,Takuwa Y

更新日期：2006-06-23 00:00:00

abstract：:Computer-based approaches identified PTE2 as a candidate human peroxisomal acyl-CoA thioesterase gene. The PTE2 gene product is highly similar to the rat cytosolic and mitochondrial thioesterases, CTE1 and MTE1, respectively, and terminates in a tripeptide sequence, serine-lysine-valine(COOH), that resembles the conse...

journal_title：Biochemical and biophysical research communications

authors： Jones JM,Gould SJ

更新日期：2000-08-18 00:00:00

abstract：:We found that rat bone marrow-derived macrophages responded to opsonized zymosan by releasing superoxide anion. However, these cells were defective in the response to the potent oxidative burst activator phorbol myristate acetate (PMA). This result was observed whatever the concentration of agonist used and with diffe...

journal_title：Biochemical and biophysical research communications

authors： Andre P,Capo C,Mege JL,Benoliel AM,Bongrand P

更新日期：1988-03-15 00:00:00

abstract：:Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre. The initial iodine content of the protein (0.038%) has been increased to levels of 0.16% and 0.85% by in vitro treatment with thyroid peroxidase and the resulting proteins studied with respect to their intrinsic fluorescen...

journal_title：Biochemical and biophysical research communications

authors： Zabel KM,Rawitch AB

更新日期：1984-05-31 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Today, AD can be diagnosed with certainty only post-mortem, by histopathologic staining of Abeta plaques and neurofibrillary tangles in brain tissue sections. We have developed an ultra-sensitive assay potential...

journal_title：Biochemical and biophysical research communications

authors： Funke SA,Birkmann E,Henke F,Görtz P,Lange-Asschenfeldt C,Riesner D,Willbold D

更新日期：2007-12-28 00:00:00

abstract：:To repair bone defects, we evaluate the in-vitro and in-vivo osteogenic activities of a novel tissue-engineered bone (TEB) by elaborately combining biomimetic calcium phosphate (BioCaP) granules with internally-incorporated simvastatin (SIM) and human adipose-derived stem cells (hASCs). First, we constructed BioCaP wi...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Jiang W,Liu Y,Zhang P,Wang L,Li W,Wu G,Ge Y,Zhou Y

更新日期：2018-01-01 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00

abstract：:Src homology 2 (SH2) domains mediate phosphotyrosine (pY)-dependent protein:protein interactions involved in signal transduction pathways. We have found that the SH2 domains of the 85-kDa alpha subunit (p85) of phosphatidylinositol 3-kinase (PI3 kinase) bind directly to the serine/threonine kinase A-Raf. In this repor...

journal_title：Biochemical and biophysical research communications

authors： Fang Y,Johnson LM,Mahon ES,Anderson DH

更新日期：2002-02-01 00:00:00

abstract：:Professional phagocytes contain a unique NADPH oxidase responsible for the production of microbicidal oxidants. Activation of this oxidase requires participation of cytosolic and membrane proteins, but the interactions of these components are incompletely understood. Patients with autosomal recessive Chronic Granuloma...

journal_title：Biochemical and biophysical research communications

authors： Levy R,Malech HL,Rotrosen D

更新日期：1990-08-16 00:00:00

abstract：:It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles...

journal_title：Biochemical and biophysical research communications

authors： Chen F

更新日期：2005-06-24 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity ...

journal_title：Biochemical and biophysical research communications

authors： Garcia RL,Schilling WP

更新日期：1997-10-09 00:00:00

abstract：:Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to th...

journal_title：Biochemical and biophysical research communications

authors： Di Filippo ES,Mancinelli R,Pietrangelo T,La Rovere RM,Quattrocelli M,Sampaolesi M,Fulle S

更新日期：2016-04-29 00:00:00

abstract：:Previous structural and mutational studies of bovine pancreatic deoxyribonuclease I (bpDNase I) have demonstrated that the active site His134 and His252 played critical roles in catalysis. In our present study, mutations of these two His residues to Gln, Ala or Gly reduced the DNase activity by a factor of four to fiv...

journal_title：Biochemical and biophysical research communications

authors： Chen WJ,Lai PJ,Lai YS,Huang PT,Lin CC,Liao TH

更新日期：2007-01-19 00:00:00