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ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.

Abstract：

:ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created transgenic mice overexpressing ICSAT in lymphocytes. Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT. ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito T,Yamagata T,Takahashi T,Honda H,Hirai H

doi

10.1006/bbrc.1999.0911

subject

Has Abstract

pub_date

1999-07-05 00:00:00

pages

329-31

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90911-7

journal_volume

260

pub_type

杂志文章

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