No evidence for mutations in a putative subunit of the beta-cell ATP-sensitive potassium channel (K-ATP channel) in Japanese NIDDM patients.

Abstract:

:The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patients. The coding region of this beta-cell type channel gene was investigated in 192 diabetics with a family history of the disorder by single-stranded conformational polymorphism (SSCP) analysis. Two silent polymorphisms were found and confirmed by sequencing, but no missense or nonsense mutations were detected. The allele frequency of the polymorphisms was compared with 96 control subjects without a family history of the disease, and no clear difference was found. These results indicate that genetic defects of the KATP-2 channel may not be a major cause of diabetes in Japan.

authors

Yasuda K,Sakura H,Mori Y,Iwamoto K,Shimokawa K,Kadowaki H,Hagura R,Akanuma Y,Adelman JP,Yazaki Y

doi

10.1006/bbrc.1995.1915

subject

Has Abstract,Author List Incomplete

pub_date

1995-06-26 00:00:00

pages

1036-40

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X85719158

journal_volume

211

pub_type

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