Abstract:
:The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patients. The coding region of this beta-cell type channel gene was investigated in 192 diabetics with a family history of the disorder by single-stranded conformational polymorphism (SSCP) analysis. Two silent polymorphisms were found and confirmed by sequencing, but no missense or nonsense mutations were detected. The allele frequency of the polymorphisms was compared with 96 control subjects without a family history of the disease, and no clear difference was found. These results indicate that genetic defects of the KATP-2 channel may not be a major cause of diabetes in Japan.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Yasuda K,Sakura H,Mori Y,Iwamoto K,Shimokawa K,Kadowaki H,Hagura R,Akanuma Y,Adelman JP,Yazaki Ydoi
10.1006/bbrc.1995.1915subject
Has Abstract,Author List Incompletepub_date
1995-06-26 00:00:00pages
1036-40issue
3eissn
0006-291Xissn
1090-2104pii
S0006291X85719158journal_volume
211pub_type
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