PTH(7-84) inhibits PTH(1-34)-induced 1,25-(OH)2D3 production in murine renal tubules.

abstract：:Hippocampus is one of the most vulnerable tissues to glucocorticoid (GC). In the present study, we demonstrate that dexamethasone (DEX), a synthetic GC, induces apoptotic cell death in hippocampal progenitor HiB5 cells without any additional insult. Interestingly, expression of 27-kDa heat shock protein (HSP27) was ma...

journal_title：Biochemical and biophysical research communications

authors： Son GH,Geum D,Chung S,Park E,Lee KH,Choi S,Kim K

更新日期：2005-12-30 00:00:00

abstract：:In AL-amyloidosis the cause of amyloid fibril formation in beta-pleated sheets from the precursor protein immunoglobulin light chain is not established, but studies of AL-proteins indicate that amino acid substitutions are important in the pathogenesis. Amyloid material was extracted from a subcutaneous fat tissue bio...

journal_title：Biochemical and biophysical research communications

authors： Olsen KE,Sletten K,Westermark P

更新日期：1998-04-28 00:00:00

abstract：:The immunoproteasome is a multicatalytic protease complex in all eukaryotic cells, which plays a key role in regulating essential cellular processes. However, the role of immunoproteasome subunit β2i in regulation of cardiac fibrosis and inflammation in deoxycorticosterone-acetate (DOCA)/salt mice remains unknown. Wil...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Bi HL,Liu LX,Li NN,Liu Y,Du J,Wang HX,Li HH

更新日期：2017-08-19 00:00:00

abstract：:The family of endothelins, endothelin-1 (ET-1), ET-2 and ET-3, act on two subtypes of receptors called ETA and ETB receptors. BQ123 is an ETA-selective competitive antagonist. In this study, however, BQ123 inhibited ET-1-induced transients of cytosolic Ca2+ concentrations ([Ca2+]i) in an apparently noncompetitive mann...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto A,Yanagisawa M,Tsujimoto G,Nakao K,Toyo-oka T,Masaki T

更新日期：1994-04-29 00:00:00

abstract：:We report the modulatory effects of estrogen on release of endothelium-derived relaxing factors (EDRFs) in a human endothelial cell line, EA.hy926. Using bioassay, we showed that EA.hy926 released EDRF including nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) measured by relaxation of pre-contr...

journal_title：Biochemical and biophysical research communications

authors： Rahimian R,Chan L,Goel A,Poburko D,van Breemen C

更新日期：2004-09-17 00:00:00

abstract：:RhoD is a member of the classical Rho GTPases and it has an essential role in the regulation of actin dynamics. Furthermore, RhoD also localizes to early endosomes and recycling endosomes, indicating additional roles in the regulation of endosome trafficking. A yeast two-hybrid screen identified Zipper-Interacting Pro...

journal_title：Biochemical and biophysical research communications

authors： Nehru V,Almeida FN,Aspenström P

更新日期：2013-04-05 00:00:00

abstract：:It has been shown that the protein serine/threonine phosphatase type 2A alpha catalytic subunit (PP2A alpha) has a mutation consisting of a glycine substitution for cysteine at 269 in the okadaic acid resistant variant of CHO cells, and that the mutant protein is resistant to okadaic acid (Shima, H. et al. Proc. Natl....

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Shima H,Amagasa T,Takagi M,Sugimura T,Nagao M

更新日期：1995-09-14 00:00:00

abstract：:Targeting mitochondrial respiration has been documented as an effective therapeutic strategy in cancer. However, the impact of mitochondrial respiration inhibition on cervical cancer cells are not well elucidated. Using a panel of cervical cancer cell lines, we show that an existing drug atovaquone is active against t...

journal_title：Biochemical and biophysical research communications

authors： Tian S,Chen H,Tan W

更新日期：2018-05-23 00:00:00

abstract：:A nonreducible cyclic analog of somatostatin (SRIF) was prepared by a combination of solid phase and solution peptide synthesis. The compound, gamma-Abu-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Asp-OH, was tested for its effect on the release of growth hormone, glucagon and insulin in rats. It significantly suppressed ...

journal_title：Biochemical and biophysical research communications

authors： Garsky VM,Clark DE,Grant NH

更新日期：1976-12-20 00:00:00

abstract：:It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the capacity to differentiate into cells of endothelial and hepatocyte lineages. The present study shows that beta-catenin-dependent canon...

journal_title：Biochemical and biophysical research communications

authors： Kordes C,Sawitza I,Häussinger D

更新日期：2008-02-29 00:00:00

abstract：:The aim of the present study was to examine the effects of p-coumaric acid on the longitudinal growth of the long bone in adolescent male rats. Teatment with p-coumaric acid significantly increased the tibial length and the height of each growth plate zone and the ratio of 5-bromo-2'-deoxyuridine-positive cells relati...

journal_title：Biochemical and biophysical research communications

authors： Lee JH,Chung YH,Kim HH,Bang JS,Jung TW,Park T,Park J,Kim U,Lee SH,Jeong JH

更新日期：2018-11-10 00:00:00

abstract：:Enhancers are essential for long range chromatin opening and the activation of V(D)J recombination at the antigen receptor loci. The murine immunoglobulin lambda light chain locus is a duplicated locus and, using a bacterial artificial chromosome spanning the 3' half of the locus to generate transgenic mice, we have i...

journal_title：Biochemical and biophysical research communications

authors： Haque SF,Bevington SL,Boyes J

更新日期：2013-11-15 00:00:00

abstract：:To assess the relationship between cell proliferation and cell death, the mRNA accumulation of ornithine decarboxylase (ODC) and sulfated glycoprotein 2 (SGP-2) were measured in human peripheral blood lymphocytes (HPBL) 2-6 hours after stimulation with phytohemagglutinin (PHA). ODC is the rate limiting enzyme of polya...

journal_title：Biochemical and biophysical research communications

authors： Grassilli E,Bettuzzi S,Monti D,Ingletti MC,Franceschi C,Corti A

更新日期：1991-10-15 00:00:00

abstract：:The vibrational frequency of CO bound to myoglobin can be varied by up to 60 cm-1 by making site-specific mutations in the distal pocket. These changes may result from specific chemical interactions between distal amino acids and the CO or from changes in the electrostatic field of the distal pocket. In this paper, we...

journal_title：Biochemical and biophysical research communications

authors： Decatur SM,Boxer SG

更新日期：1995-07-06 00:00:00

abstract：:Kupffer cells, prepared 18 h after pretreatment of rats with a single dose of halothane, did carry TFA-adducts which were recognized on Western blots by a anti-TFA-antibody. Based on apparent molecular weight, the pattern of the major TFA-adducts within Kupffer cells was similar to that observed in hepatocytes. When k...

journal_title：Biochemical and biophysical research communications

authors： Christen U,Bürgin M,Gut J

更新日期：1991-02-28 00:00:00

abstract：:A large proportion of the NSCLC patients were insensitive to radiotherapy, but the exact mechanism is still unclear. This study explored the role of miR-25 in regulating sensitivity of NSCLC cells to ionizing radiation (IR) and its downstream targets. Based on measurement in tumor samples from NSCLC patients, this stu...

journal_title：Biochemical and biophysical research communications

authors： He Z,Liu Y,Xiao B,Qian X

更新日期：2015-02-13 00:00:00

abstract：:A new 1,25-dihydroxyvitamin D3 analog, 22-oxa-1,25(OH)2D3, which may have pharmaceutical use, e.g., in the treatment of psoriasis, was studied using cultured MG-63 human osteosarcoma cells. We found that the new compound binds to 1,25-dihydroxyvitamin D receptors and regulates receptor mRNA levels like the natural lig...

journal_title：Biochemical and biophysical research communications

authors： Valaja T,Mahonen A,Pirskanen A,Mäenpää PH

更新日期：1990-06-15 00:00:00

abstract：:We used fluorescence correlation spectroscopy (FCS) to study the activation of fibrinogen by thrombin and the subsequent aggregation of fibrin monomers into fibrin polymers at a very low and at physiological fibrinogen concentrations. In the labeling procedure used the fibrinogen was randomly labeled and the label was...

journal_title：Biochemical and biophysical research communications

authors： Bark N,Földes-Papp Z,Rigler R

更新日期：1999-06-24 00:00:00

abstract：:Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcript...

journal_title：Biochemical and biophysical research communications

authors： Tabuchi A,Nakatani C,Nakaoka R,Naruse Y,Kojima T,Mori N,Tsuda M

更新日期：1999-08-02 00:00:00

abstract：:Rapidly activating Kv4 voltage-gated ion channels are found in heart, brain, and diverse other tissues including colon and uterus. Kv4.3 can co-assemble with KChIP ancillary subunits, which modify kinetic behavior. We examined the affinity and use dependence of nifedipine block on Kv4.3 and its modulation by KChIP2b. ...

journal_title：Biochemical and biophysical research communications

authors： Bett GC,Morales MJ,Strauss HC,Rasmusson RL

更新日期：2006-02-24 00:00:00

abstract：:Atrial- and brain-type natriuretic peptides (ANP and BNP, respectively) have been shown to exert potent lipolytic action in adipocytes. A family of natriuretic peptide receptors (NPRs), NPR-1, NPR-2, and NPR-3, mediates their physiologic effects. NPR-1 and NPR-2 are receptor guanylyl cyclases, while NPR-3 lacks enzyma...

journal_title：Biochemical and biophysical research communications

authors： Nakatsuji H,Maeda N,Hibuse T,Hiuge A,Hirata A,Kuroda Y,Kishida K,Kihara S,Funahashi T,Shimomura I

更新日期：2010-01-29 00:00:00

abstract：:BMP-3b (also called GDF-10) is a novel BMP-3-related protein recently discovered in rat femur tissue. Gene expression of BMP-3b in osteoblastic cells and its regulation by prolonged culture, BMP-2 and transforming growth factor beta1 (TGF-beta1) were examined. The BMP-3b gene was highly expressed in rat osteoblasts ob...

journal_title：Biochemical and biophysical research communications

authors： Hino J,Matsuo H,Kangawa K

更新日期：1999-03-16 00:00:00

abstract：:Invaison plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri inv...

journal_title：Biochemical and biophysical research communications

authors： Marquart ME,Picking WL,Picking WD

更新日期：1995-09-25 00:00:00

abstract：:In the current study, we have examined the role of serotonin in regulating the levels of methyl farnesoate and ecdysteroids in the giant mud crab Scylla serrata and validated that serotonin indeed is a reproductive hormone. Administration of serotonin elevated circulatory levels of methyl farnesoate and ecdysteroids i...

journal_title：Biochemical and biophysical research communications

authors： Girish BP,Swetha CH,Reddy PS

更新日期：2017-09-02 00:00:00

abstract：:Professional phagocytes contain a unique NADPH oxidase responsible for the production of microbicidal oxidants. Activation of this oxidase requires participation of cytosolic and membrane proteins, but the interactions of these components are incompletely understood. Patients with autosomal recessive Chronic Granuloma...

journal_title：Biochemical and biophysical research communications

authors： Levy R,Malech HL,Rotrosen D

更新日期：1990-08-16 00:00:00

abstract：:O-GlcNAcylation is a reversible post-translational modification that regulates cytosolic and nuclear proteins. We and others previously demonstrated that FoxO1 is O-GlcNAcylated in different cell types, resulting in an increase in its transcriptional activity. Four O-GlcNAcylation sites were identified in human FOXO1 ...

journal_title：Biochemical and biophysical research communications

authors： Fardini Y,Perez-Cervera Y,Camoin L,Pagesy P,Lefebvre T,Issad T

更新日期：2015-06-26 00:00:00

abstract：:Opioid binding properties of Tyr-D-Ser-Gly-Phe-Leu-Thr-NH-NH-Gly-Mal (DSLET-Mal), a novel enkephalin-framed affinity label, was determined in rat brain membranes. In competition studies the ligand showed high affinity for the delta opioid sites, labelled by [(3)H][Ile(5,6)]deltorphin II (K(i) = 8 nM), whereas its bind...

journal_title：Biochemical and biophysical research communications

authors： Szatmári I,Orosz G,Medzihradszky K,Borsodi A

更新日期：1999-11-19 00:00:00

abstract：:In a span of approximately 13 kb, two genomic fragments showing an obvious overlap encoded the 1,192 base pair (bp) cDNA sequence for human H-protein. Because of the close similarity in the genomic organization comprised of five exons to that for the chicken H-protein gene, this region was assigned to the true H-prote...

journal_title：Biochemical and biophysical research communications

authors： Koyata H,Hiraga K

更新日期：1991-08-15 00:00:00

abstract：:Strikingly variable clinical phenotypes can be found in X-linked adrenoleukodystrophy (X-ALD) even with the same ABCD1 mutation. ABCD2 is the closest homolog to ABCD1. Since ABCD2 overexpression complements the loss of ABCD1 in vivo and in vitro, we have investigated the possible role of the ABCD2 gene locus as determ...

journal_title：Biochemical and biophysical research communications

authors： Maier EM,Mayerhofer PU,Asheuer M,Köhler W,Rothe M,Muntau AC,Roscher AA,Holzinger A,Aubourg P,Berger J

更新日期：2008-12-05 00:00:00

abstract：:The application of Fast Atom Bombardment Mass Spectrometry to the measurement of small differences in molecular weight is discussed in relation to the spectra of bovine proinsulin and a genetic variant. ...

journal_title：Biochemical and biophysical research communications

authors： Cottrell JS,Frank BH

更新日期：1985-03-29 00:00:00