Abstract:
:In addition to the well established cyclooxygenase pathway, cultured aortic smooth muscle cells convert arachidonic acid to several polar metabolites identified by high performance liquid chromatography and gaz chromatography-mass spectrometry. 15-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid and 5-Hydroxyeicosatetraenoic acid are the major products formed. These observations indicate that the rabbit aortic smooth muscle cells are a potential source of lipoxygenase products and raise the possibility that this pathway of arachidonic acid metabolism can influence the biological functions of arterial myocytes under normal and pathological conditions.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Larrue J,Rigaud M,Razaka G,Daret D,Demond-Henri J,Bricaud Hdoi
10.1016/0006-291x(83)91822-3subject
Has Abstractpub_date
1983-04-15 00:00:00pages
242-9issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(83)91822-3journal_volume
112pub_type
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