Abstract:
:In the rat mammary tumoral cell line (WRK1 cells), vasopressin was previously described to stimulate a phospholipase C. In this study, we have analysed the effect of vasopressin both on intracellular calcium mobilization and on the accumulation of inositol phosphates. Maximal concentration of vasopressin simultaneously induces an accumulation of Ins(1,4,5)P3 and a rise of intracellular calcium concentration. Both these two phenomena are transient and exhibit similar kinetics. A sustained accumulation of InsP2, Ins(1,3,4)P3 and InsP are observed later. Yet no stimulation of InsP4 can be objectified. These results indicate that Ins(1,4,5)P3 is the major inositol phosphate involved in intracellular calcium mobilization.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Mouillac B,Balestre MN,Guillon Gdoi
10.1016/0006-291x(89)92201-8subject
Has Abstractpub_date
1989-03-31 00:00:00pages
953-60issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(89)92201-8journal_volume
159pub_type
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更新日期:2020-01-29 00:00:00