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PIH1D1, a subunit of R2TP complex, inhibits doxorubicin-induced apoptosis.

Abstract：

:We have previously reported that the two components of R2TP complex, RNA polymerase II-associated protein 3 (RPAP3), and Reptin, regulate apoptosis. Here we characterize another component of the complex, PIH1 domain containing protein 1 (PIH1D1). PIH1D1 interacts with both RPAP3 and Monad in HEK293 or U2OS cells. PIH1D1 transcripts were abundant in lung, leukocyte, and placenta. The reduction in endogenous PIH1D1 by siRNA enhanced apoptosis and caspase-3 activation induced by doxorubicin in U2OS cells. These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Inoue M,Saeki M,Egusa H,Niwa H,Kamisaki Y

doi

10.1016/j.bbrc.2010.11.031

subject

Has Abstract

pub_date

2010-12-17 00:00:00

pages

340-4

issue

3-4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02079-6

journal_volume

403

pub_type

杂志文章

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