Phorbol ester induces differential membrane-association of protein kinase C subspecies in human platelets.

Abstract:

:Human platelets contained proteins which cross-reacted with antisera specific for brain protein kinase C-alpha and -beta. When platelets were incubated with 12-O-tetradecanoylphorbol-13-acetate there was a rapid accumulation of protein kinase C-alpha in the particulate fraction associated with a loss of this subspecies from the soluble fraction. No particulate accumulation or soluble loss of protein kinase C-beta could be detected when platelets were incubated with the phorbol ester.

authors

Fournier A,Hardy SJ,Clark KJ,Murray AW

doi

10.1016/0006-291x(89)92635-1

subject

Has Abstract

pub_date

1989-06-15 00:00:00

pages

556-61

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92635-1

journal_volume

161

pub_type

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