Regulation by thyroid hormone and retinoic acid of the CCAAT/enhancer binding protein alpha and beta genes during liver development.

abstract：:A ketosugar-specific agglutinin has been identified and purified to apparent homogeneity by affinity chromatography from the three days post-coital rat uterus. This protein is not found in other stages of estrous cycle. The agglutinin is glycoprotein, moves as single band with molecular weight 37,000 in polyacrylamide...

journal_title：Biochemical and biophysical research communications

authors： Chowdhury M

更新日期：1986-04-14 00:00:00

abstract：INTRODUCTION:Radiotherapy is an equivalent alternative or complement to radical prostatectomy, with high therapeutic efficacy. High risk patients, however, experience high relapse rates, so that research on radio-sensitization is the most evident route to improve curability of this common disease. MATERIALS AND METHOD...

journal_title：Biochemical and biophysical research communications

authors： Koukourakis MI,Kalamida D,Mitrakas A,Pouliliou S,Kalamida S,Sivridis E,Giatromanolaki A

更新日期：2015-05-29 00:00:00

abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

journal_title：Biochemical and biophysical research communications

authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

更新日期：2011-08-26 00:00:00

abstract：:To investigate the role of secondary structure in the substrate specificity of human 72 kDa type IV collagenase, we synthesised linear and cyclic collagen sequence analogs. As Ca2+ plays a crucial role in the enzyme activity, the CD and FTIR spectra of the peptides were also measured in the presence of Ca2+. Most of t...

journal_title：Biochemical and biophysical research communications

authors： Likó Z,Botyánszki J,Bódi J,Vass E,Majer Z,Hollósi M,Süli-Vargha H

更新日期：1996-10-14 00:00:00

abstract：:Tropomyosins are a family of actin binding proteins encoded by a group of highly conserved genes. Humans have four tropomyosin-encoding genes: TPM1, TPM2, TPM3, and TPM4, each of which is known to generate multiple isoforms by alternative splicing, promoters, and 3' end processing. TPM1 is the most versatile and encod...

journal_title：Biochemical and biophysical research communications

authors： Denz CR,Narshi A,Zajdel RW,Dube DK

更新日期：2004-08-06 00:00:00

abstract：:The effect of 1,25-(OH)2D3 on Concanavalin-A (ConA) mediated bovine lymphocyte proliferation was dependent on the magnitude of the proliferative response. Lymphocytes from cows with high inherent proliferative responses (134,904 +/- 15,488 cpm/well) were unaffected by 1,25-(OH)2D3; whereas, lymphocytes from cows with ...

journal_title：Biochemical and biophysical research communications

authors： Hustmyer FG,Nonnecke BJ,Beitz DC,Horst RL,Reinhardt TA

更新日期：1988-04-29 00:00:00

abstract：:Hepatic stellate cells (HSCs) are major players in liver fibrogenesis. Accumulating evidence shows that suppression of autophagy plays an important role in the development and progression of liver disease. Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) an...

journal_title：Biochemical and biophysical research communications

authors： Seo HY,Jang BK,Jung YA,Lee EJ,Kim HS,Jeon JH,Kim JG,Lee IK,Kim MK,Park KG

更新日期：2014-06-20 00:00:00

abstract：:The upstream activating region that controls cellulose-induced expression of the glucose-repressible cellobiohydrolase I gene (UARcb1) of the filamentous fungus Trichoderma reesei is shown to mediate transcription and glucose repression of a reporter gene in Saccharomyces cerevisiae, a unicellular microorganism that l...

journal_title：Biochemical and biophysical research communications

authors： Carraro DM,Ferreira Júnior JR,Schumacher R,Pereira GG,Hollenberg CP,El-Dorry H

更新日期：1998-12-18 00:00:00

abstract：:Formate dehydrogenase ( FDH ) from Clostridium thermoaceticum is a known tungsten enzyme. FDH was tested for the presence of nitrogenase-type cofactor and nitrate reductase-type cofactor by the Azotobacter vinelandii UW-45 and Neurospora crassa nit-1 reconstitution assays, respectively. Tungsten formate dehydrogenase ...

journal_title：Biochemical and biophysical research communications

authors： Deaton JC,Solomon EI,Durfor CN,Wetherbee PJ,Burgess BK,Jacobs DB

更新日期：1984-06-29 00:00:00

abstract：:Human epithelial cancers account for approximately 50% of all cancer deaths. This type of cancer is characterized by excessive activation and expression of the epidermal growth factor receptor (EGFR). The EGFR pathway is critical for cancer cell proliferation, survival, metastasis and angiogenesis. The EGF-EGFR signal...

journal_title：Biochemical and biophysical research communications

authors： Lan KH,Shih YS,Chang CA,Yen SH,Lan KL

更新日期：2012-11-16 00:00:00

abstract：:An essential pre-requisite to perform sound quantitative real-time polymerase chain reaction (qPCR) assays is to design outstanding primer pairs. This means they must have a good efficiency and be not prone to produce multiple amplicons or primer dimer products. To circumvent these issues, several softwares are availa...

journal_title：Biochemical and biophysical research communications

authors： Nonis A,Scortegagna M,Nonis A,Ruperti B

更新日期：2011-12-02 00:00:00

abstract：:The synthesis of extracellular matrix including collagen during wound healing responses involves signaling via reactive oxygen species (ROS). We hypothesized that NADPH oxidase isoform Nox4 facilitates the stimulatory effects of the profibrotic cytokine transforming growth factor (TGF) β(1) on collagen production in v...

journal_title：Biochemical and biophysical research communications

authors： Chan EC,Peshavariya HM,Liu GS,Jiang F,Lim SY,Dusting GJ

更新日期：2013-01-18 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the...

journal_title：Biochemical and biophysical research communications

authors： Kim HG,Han EH,Im JH,Lee EJ,Jin SW,Jeong HG

更新日期：2015-09-25 00:00:00

abstract：:We studied the regulation of glutathione (GSH) synthesis and characterised the 5'-promoter region of the gamma-glutamylcysteine synthetase-heavy subunit (gammaGCS-HS) gene in human alveolar type II cells (A549) following exposure to menadione (MQ) and hydrogen peroxide (H2O2). Both MQ (100 microM) and H2O2 (100 microM...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Bel A,Mulier B,Lawson MF,Harrison DJ,Macnee W,Smith CA

更新日期：1996-12-24 00:00:00

abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

journal_title：Biochemical and biophysical research communications

authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

更新日期：2009-10-23 00:00:00

abstract：:A real-time RT-PCR assay using newly designed primers was developed to analyze developmental and adult MHC mRNA expression both in skeletal muscles and single fibers. Only 4 ng of total RNA was necessary for the analysis of the relative mRNA expression of MHC genes. Different validation steps were realized concerning ...

journal_title：Biochemical and biophysical research communications

authors： Sanchez H,Chapot R,Banzet S,Koulmann N,Birot O,Bigard AX,Peinnequin A

更新日期：2006-02-03 00:00:00

abstract：:The cDNA encoding Mn peroxidase isozyme H4 from Phanerochaete chrysosporium was recombined into a baculovirus and heterologously expressed in Sf9 cells. The recombinant Mn peroxidase has the same molecular weight as the native enzyme as determined by SDS-PAGE and cross-reacts with a Mn peroxidase-specific antibody. Th...

journal_title：Biochemical and biophysical research communications

authors： Pease EA,Aust SD,Tien M

更新日期：1991-09-16 00:00:00

abstract：:Long-term neuropathic pain can lead to anxiety, depression, and other issues, which seriously affect patients' quality of life. For this reason, it is important to find effective treatments. Studies have shown that glial cell-derived neurotrophic factor (GDNF) can relieve neuropathic pain. However, its mechanism of ac...

journal_title：Biochemical and biophysical research communications

authors： Pan Y,Jiang L,Wang C

更新日期：2020-02-05 00:00:00

abstract：:High homocysteine (Hcy) levels are a well-known independent risk factor for endothelial damage in atherosclerosis. We examined whether a rat intestinal model of ischemia-reperfusion was associated with high Hcy and with the modification of plasma albumin into cysteinylated species (CysAlb). The three treatment groups ...

journal_title：Biochemical and biophysical research communications

authors： Bar-Or D,Curtis CG,Sullivan A,Rael LT,Thomas GW,Craun M,Bar-Or R,Maclean KN,Kraus JP

更新日期：2004-12-24 00:00:00

abstract：:The ATP-sensitive K channel (K-ATP channel) in pancreatic beta cells is believed to play a crucial role in glucose-stimulated insulin release. We investigated whether defects in the recently cloned gene for a putative subunit of this channel (KATP-2) could be a cause of diabetes in Japanese patients. The coding region...

journal_title：Biochemical and biophysical research communications

authors： Yasuda K,Sakura H,Mori Y,Iwamoto K,Shimokawa K,Kadowaki H,Hagura R,Akanuma Y,Adelman JP,Yazaki Y

更新日期：1995-06-26 00:00:00

abstract：:An attempt was made to activate the capillary-bound fraction of lipoprotein lipase (LPL) with cAMP-dependent protein kinase catalytic subunit (PKC). Following a 30s washout period, hearts were perfused for 1 min with buffer containing heparin. Medium was collected during the second 30s of heparin perfusion. Addition o...

journal_title：Biochemical and biophysical research communications

authors： Oscai LB,Caruso RA,Palmer WK

更新日期：1986-02-26 00:00:00

abstract：:The apoform of neurocuprein, the copper protein from brain and chromaffin granules, was found to be a potent inhibitor of the hydroxylating activity of dopamine beta-monooxygenase, whereas the holoform of neurocuprein has no effect on the activity of the enzyme. The inhibiting capacity of neurocuprein may be due to th...

journal_title：Biochemical and biophysical research communications

authors： Markossian KA,Paitian NA,Mikaelyan MV,Nalbandyan RM

更新日期：1986-07-16 00:00:00

abstract：:We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu 1) Na(+) channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na(+) channels, transiently expressed in HEK 293 cel...

journal_title：Biochemical and biophysical research communications

authors： Maejima H,Kinoshita E,Yuki T,Yakehiro M,Seyama I,Yamaoka K

更新日期：2002-07-12 00:00:00

abstract：:Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway inhibitor (TFPI) in human monocyte-derived macrophages (MDMs) was induced by choles...

journal_title：Biochemical and biophysical research communications

authors： Espada S,Stavik B,Holm S,Sagen EL,Bjerkeli V,Skjelland M,Dahl TB,Espevik T,Kanse S,Sandset PM,Skretting G,Halvorsen B

更新日期：2017-09-16 00:00:00

abstract：:Proadrenomedullin N-terminal 20 peptide (PAMP) is a regulatory peptide that is found in various cell types. It is involved in many biological activities and is rich in basic and hydrophobic amino acids, a common feature of antimicrobial peptides (AMPs). In this study, the cell selectivity and antimicrobial mechanism o...

journal_title：Biochemical and biophysical research communications

authors： Ajish C,Yang S,Kumar SD,Shin SY

更新日期：2020-06-30 00:00:00

abstract：:Insulin secretion from pancreatic beta cells is partly regulated by cell membrane potential. Background K+ channels that stabilize the resting membrane potential would suppress excitability and insulin secretion. Recent studies show that members of the two-pore domain K+ (K2P) channel family behave as background K+ ch...

journal_title：Biochemical and biophysical research communications

authors： Kang D,Choe C,Kim D

更新日期：2004-10-08 00:00:00

abstract：:The effect of HMG1 on the transcriptional block caused by left-handed Z-form in a highly negatively supercoiled DNA was examined using a supercoiled plasmid containing a (CG)10 sequence downstream of promoters. The transcription by E. coli RNA polymerase was blocked at the boundary of alternating CG sequence in the Z-...

journal_title：Biochemical and biophysical research communications

authors： Waga S,Mizuno S,Yoshida M

更新日期：1988-05-31 00:00:00

abstract：:The p21(WAF-1) promoter contains binding sites for a number of transcription factors which mediate its activation by a variety of external signals. Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in diffe...

journal_title：Biochemical and biophysical research communications

authors： Schavinsky-Khrapunsky Y,Huleihel M,Aboud M,Torgeman A

更新日期：2003-05-16 00:00:00

abstract：:IL-10 is known to suppress the inflammatory responses in a variety of experimental models. Because we previously found that whole-body X-irradiation causes massive apoptosis in the thymus and transient infiltration of neutrophils, in this study, we examined whether or not IL-10 is involved in the regulation of neutrop...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara H,Yamazaki T,Uzawa A,Nagata K,Kobayashi Y

更新日期：2008-05-02 00:00:00

abstract：:Gastric epithelial cells (GES-1) stimulated by Helicobacter pylori (H. pylori) would affect the expression of related genes and induce the immune response of the cells. Abnormal methylation of DNA was one of the main causes. The aim of this study was to investigate phosphoinositol-3-kinase adaptor protein 1(PIK3AP1), ...

journal_title：Biochemical and biophysical research communications

authors： Zhang A,Yan S,Cao M,Wu D,Zhou J,Yu Z,Wu M,Liu Y,Lu S,Hu G,Zhao J

更新日期：2020-03-26 00:00:00