Phospholipase D1 decreases type I collagen levels in hepatic stellate cells via induction of autophagy.

abstract：:The enzymatic activity of cystathionine beta synthase has been studied in fibroblasts of nine patients with regular trisomy 21. An excess of CBS activity was found in trisomy 21 with a trisomy 21/normal ratio equal to 1.66. A 1.04 ratio was found in 21q21----21 p ter monosomy; a 1.04 and 0.99 ratio was found in two 21...

journal_title：Biochemical and biophysical research communications

authors： Chadefaux B,Rethoré MO,Raoul O,Ceballos I,Poissonnier M,Gilgenkranz S,Allard D

更新日期：1985-04-16 00:00:00

abstract：:We identified a DNA polymerase species in Drosophila melanogaster embryos, and purified it. This polymerase shared some common properties with DNA polymerase epsilon from mammals and yeast as follows; it has a preference for poly(dA)/oligo(dT) as a template/primer, it is highly processive in DNA synthesis, it co-fract...

journal_title：Biochemical and biophysical research communications

authors： Aoyagi N,Oshige M,Hirose F,Kuroda K,Matsukage A,Sakaguchi K

更新日期：1997-01-13 00:00:00

abstract：:Using a human placenta cDNA library, we cloned a novel member belonging to the scavenger receptor family. Complementary DNA of this clone encodes a type II transmembranous glycoprotein containing a collagen-like domain, which are typical structural characteristics of scavenger receptor class A. This protein also conta...

journal_title：Biochemical and biophysical research communications

authors： Nakamura K,Funakoshi H,Miyamoto K,Tokunaga F,Nakamura T

更新日期：2001-02-02 00:00:00

abstract：:An expression library established in lambda gt11 with cDNA from squamous epithelium of the human upper digestive tract was screened with an antibody raised against keratin 13. A 1.2 kb fragment from the most strongly reacting plaque was sequenced and compared to known type I keratin sequences. The highest degree of ho...

journal_title：Biochemical and biophysical research communications

authors： Schulz P,Wachter E,Hochstrasser K,Wild AG,Mischke D

更新日期：1989-08-15 00:00:00

abstract：:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. Howev...

journal_title：Biochemical and biophysical research communications

authors： Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

更新日期：2021-01-01 00:00:00

abstract：:Reverse cholesterol transport (RCT) plays an important role in cholesterol and lipid metabolism. Regulating the activities of key transporters and receptors in RCT, such as ATP-binding cassette transporter A1 (ABCA1), helps to prevent atherosclerotic cardiovascular disease. In this study, we used an ABCA1 promoter luc...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Luo J,Li N,Liu L,Han X,Liu C,Zuo X,Jiang X,Li Y,Xu Y,Si S

更新日期：2018-09-26 00:00:00

abstract：:Previously, we reported the identification and characterization of a novel cancer/testis antigen gene, CAGE(4), that was expressed in various histological types of tumors, but not in normal tissues, with the exception of the testis. To date, molecular mechanisms for the expression of CAGE have never been studied. In o...

journal_title：Biochemical and biophysical research communications

authors： Cho B,Lee H,Jeong S,Bang YJ,Lee HJ,Hwang KS,Kim HY,Lee YS,Kang GH,Jeoung DI

更新日期：2003-07-18 00:00:00

abstract：:It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT(3)) receptor to cause nausea and vomiting. In general, antagonist for 5-HT(3) receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinoteca...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ishida Y,Yamada T,Shimada S

更新日期：2011-11-18 00:00:00

abstract：:Apolipoprotein E (apoE), a protein mainly involved in lipid metabolism, is associated with several neurodegenerative disorders including Alzheimer's disease. Despite numerous attempts to elucidate apoE gene regulation in the brain, the exact mechanism is still uncovered. The mechanism of apoE gene regulation in the br...

journal_title：Biochemical and biophysical research communications

authors： Roman C,Fuior EV,Trusca VG,Kardassis D,Simionescu M,Gafencu AV

更新日期：2015-12-04 00:00:00

abstract：:Previous studies reported increased expression and activity of neutrophil elastase (NE) in NASH. However, the role of NE in nonalcoholic steatohepatitis (NASH) remained unclear. Wild type (WT) and NE knockout (NE KO) mice were fed with western diet (WD) for 24 weeks to establish NASH model. The severity of liver injur...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Liang B,Bian D,Luo Y,Yang J,Li Z,Zhuang Z,Zang S,Shi J

更新日期：2019-10-22 00:00:00

abstract：:Thrombomodulin (TM) is a cell-surface glycoprotein and a critical mediator of endothelial anticoagulant function. TM exists as both a chondroitin sulfate (CS) proteoglycan (PG) form and a non-PG form lacking a CS chain (α-TM); therefore, TM can be described as a part-time PG. Previously, we reported that α-TM bears an...

journal_title：Biochemical and biophysical research communications

authors： Izumikawa T,Kitagawa H

更新日期：2015-05-01 00:00:00

abstract：:Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood ...

journal_title：Biochemical and biophysical research communications

authors： Ende N,Chen R,Reddi AS

更新日期：2004-12-17 00:00:00

abstract：:Hepatitis A virus (HAV) protein 3AB is a membrane-interacting protein containing a stretch of 21 hydrophobic amino acid residues. The nature of its membrane association was studied in detail by analysing various deletion mutants. In vivo and in vitro expression of the wild-type protein and its mutants allowed to demon...

journal_title：Biochemical and biophysical research communications

authors： Ciervo A,Beneduce F,Morace G

更新日期：1998-08-10 00:00:00

abstract：:In general, translation efficiency of ferritin mRNAs is modulated by variations in iron supply. In primary avian erythroblasts undergoing short-term proliferation, however, ferritin heavy chain (ferH) mRNA is repressed at all iron levels. Yet, expression of v-ErbA oncoprotein is sufficient to reinduce ferH mRNA utiliz...

journal_title：Biochemical and biophysical research communications

authors： Mikulits W,Schranzhofer M,Deiner EM,Beug H,Müllner EW

更新日期：2000-08-28 00:00:00

abstract：:We established cell lines that stably express orphan GPCR GPR174 using CHO cells, and studied physiological and pharmacological features of the receptor. GPR174-expressing cells showed cell-cell adhesion with localization of actin filaments to cell membrane, and revealed significant delay of cell proliferation. Since ...

journal_title：Biochemical and biophysical research communications

authors： Sugita K,Yamamura C,Tabata K,Fujita N

更新日期：2013-01-04 00:00:00

abstract：:Mangosteen, a fruit mainly produced in Southeast Asia, has been used as food and as an antipyretic and for treating skin diseases. The xanthones contained in mangosteen have many physiological activities including melanin suppression and anticancer activities, but little is known about the physiological effects of the...

journal_title：Biochemical and biophysical research communications

authors： Lin M,Zhou S,Sakamoto K

更新日期：2020-07-12 00:00:00

abstract：:Cytosolic free calcium concentration ([Ca(2+)]i) is a central signalling element for the maintenance of endothelial barrier function. Under physiological conditions, it is controlled within narrow limits. Metabolic inhibition during ischemia/reperfusion, however, induces [Ca(2+)]i overload, which results in barrier fa...

journal_title：Biochemical and biophysical research communications

authors： Bosche B,Schäfer M,Graf R,Härtel FV,Schäfer U,Noll T

更新日期：2013-05-03 00:00:00

abstract：:An antiserum was generated against a C-terminal peptide of the mouse activin type II receptor (ActR-II), which specifically immunoprecipitates ActR-II protein transiently expressed in COS-1 cells. Autophosphorylation activity of the ActR-II was examined in [32P]orthophosphate labeled COS-1 cells. The immunoprecipitate...

journal_title：Biochemical and biophysical research communications

authors： Ichijo H,Yamashita H,ten Dijke P,Eto Y,Heldin CH,Miyazono K

更新日期：1993-08-16 00:00:00

abstract：:Stretch activation of cation-permeable channels may be an important proximal sensory mechanism in mechanotransduction. As actin filaments may mediate cellular responses to changes of the mechanical properties of the substrate and regulate stretch-induced calcium transients, we examined the role of actin filaments and ...

journal_title：Biochemical and biophysical research communications

authors： Wu Z,Wong K,Glogauer M,Ellen RP,McCulloch CA

更新日期：1999-08-02 00:00:00

abstract：:c-Fes plays pivotal roles in angiogenic cellular responses of endothelial cells. Here we examined the role of c-Fes in vascular endothelial growth factor-A (VEGF-A)-mediated signaling pathways in endothelial cells. We introduced either wild-type or kinase-inactive c-Fes in porcine aortic endothelial (PAE) cell lines, ...

journal_title：Biochemical and biophysical research communications

authors： Kanda S,Mochizuki Y,Miyata Y,Kanetake H

更新日期：2003-07-11 00:00:00

abstract：:We have purified and isolated a novel, hypotensive peptide from avian ventricular tissue. Ventricular homogenates have been shown to exhibit potent hypotensive activity in the avian and mammalian species, with little natriuresis or diuresis. Using avian mean arterial pressure (MAP) as a bioassay, we were able to purif...

journal_title：Biochemical and biophysical research communications

authors： Barbato GF,Wideman RF

更新日期：1990-06-29 00:00:00

abstract：:The effect of thyroid hormone and retinoic acid on the expression of CCAAT/enhancer binding proteins (C/EBPs) alpha and beta was investigated in rat liver during development. Congenital hypothyroidism caused a significant decrease in both C/EBP alpha and C/EBP beta gene expression at early stages of postnatal developm...

journal_title：Biochemical and biophysical research communications

authors： Menéndez-Hurtado A,Vega-Núñez E,Santos A,Perez-Castillo A

更新日期：1997-05-29 00:00:00

abstract：:Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no ...

journal_title：Biochemical and biophysical research communications

authors： Lascu I,Edwards B,Cucuianu MP,Deamer DW

更新日期：1988-10-31 00:00:00

abstract：:Systemic sclerosis (SSc) or scleroderma is a generalized disorder of connective tissue. The etiology is poorly understood; however, both genetic and environmental factors have been implicated. To investigate the disease-susceptible gene for SSc, we examined the association of the disease with a gene (COL1A2) for type ...

journal_title：Biochemical and biophysical research communications

authors： Hata R,Akai J,Kimura A,Ishikawa O,Kuwana M,Shinkai H

更新日期：2000-05-27 00:00:00

abstract：:Calmodulin (CaM) plays a crucial role in metabolism and physiology of eukaryotes by regulating biological activities. Multiple lines of evidences indicate that the phosphorylated flavonoids possess relatively stronger affinities for proteins by forming non-covalent complexes with them, and that the cellular functions ...

journal_title：Biochemical and biophysical research communications

authors： Li L,Wei DQ,Wang JF,Chou KC

更新日期：2007-07-13 00:00:00

abstract：:The molecular mechanisms of the endothelial fibrinolytic activities modulated by mechanical strain are not clear. Endothelial cells (ECs) grown on a flexible membrane base were deformed with sinusoidal negative pressures to produce an average strain of 12%. Cyclic strain induced PAI-1 release in a time-dependent manne...

journal_title：Biochemical and biophysical research communications

authors： Cheng JJ,Chao YJ,Wung BS,Wang DL

更新日期：1996-08-05 00:00:00

abstract：:The interaction of adrenodoxin (Adx) and NADPH cytochrome P450 reductase (CPR) with human microsomal steroidogenic cytochrome P450s was studied. It is found that Adx, mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450s: full length CYP17, truncated CYP17, and trunc...

journal_title：Biochemical and biophysical research communications

authors： Pechurskaya TA,Harnastai IN,Grabovec IP,Gilep AA,Usanov SA

更新日期：2007-02-16 00:00:00

abstract：:Myocardial fibrosis is the pathological consequence of injury-induced fibroblastto-myofibroblast transition, resulting in increased stiffness and diminished cardiac function. Histone modification has been shown to play an important role in the pathogenesis of cardiac fibrosis. Here, we identified H3K27me3 demethylase ...

journal_title：Biochemical and biophysical research communications

authors： Long F,Wang Q,Yang D,Zhu M,Wang J,Zhu Y,Liu X

更新日期：2020-08-06 00:00:00

abstract：:Using SDS-PAGE and MALDI-TOF mass spectrometry, we investigated the difference in the molecular structure between human and bovine ceruloplasmin. In both cases, we found that the protein is present in two majors forms of different molecular mass. The difference between human and bovine ceruloplasmin was more obvious w...

journal_title：Biochemical and biophysical research communications

authors： Boivin S,Aouffen M,Fournier A,Mateescu MA

更新日期：2001-11-09 00:00:00

abstract：:Septic shock induced by lipopolysaccharide (LPS) is characterized by serious systemic inflammatory response and robust production of pro-inflammatory cytokines from activated macrophages. Damage-associated molecular patterns (DAMPs) secreted by activated macrophages are key contributors to septic shock. However, the c...

journal_title：Biochemical and biophysical research communications

authors： He Y,Peng Y,Tao L,Peng Z,Yang H

更新日期：2020-07-05 00:00:00