Role of excess lipoyl dehydrogenase in reconstituted alpha-ketoglutarate dehydrogenase complex of Escherichia coli.

abstract：:Transforming growth factor (TGF)-beta1, a cytokine released into the cerebrospinal fluid (CSF) after intraventricular hemorrhage (IVH), stimulates the expression of the components of the extracellular matrix (ECM), which causes progressive ventricular dilatation by impaired CSF absorption. Matrix metalloproteinase-9 (...

journal_title：Biochemical and biophysical research communications

authors： Okamoto T,Takahashi S,Nakamura E,Nagaya K,Hayashi T,Fujieda K

更新日期：2009-06-12 00:00:00

abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

journal_title：Biochemical and biophysical research communications

authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

更新日期：2004-08-06 00:00:00

abstract：:Protein acetylation is an important and reversible post-translational modification (PTM), and it governs a variety of cellular dynamics and plasticity. Experimental identification of acetylation sites is labor-intensive and often limited by the availability of reagents such as acetyl-specific antibodies and optimizati...

journal_title：Biochemical and biophysical research communications

authors： Li A,Xue Y,Jin C,Wang M,Yao X

更新日期：2006-12-01 00:00:00

abstract：:Stress associated proteins (SAPs) in plants contain A20-type zinc finger (A20_ZF) domains and are involved with abiotic stress response. A20-type zinc finger domains in animals reportedly recognize ubiquitin as a regulatory signal in cell. However, it remains unclear whether A20_ZF domains in plants perform similar ro...

journal_title：Biochemical and biophysical research communications

authors： Choi H,Han S,Shin D,Lee S

更新日期：2012-03-09 00:00:00

abstract：:An important mechanism of regulation of the expression of the AT(1) receptors is the modulation of the mRNA stability. AUF1, a human RNA-binding protein, may play an important role. Since AUF1 seems to bind to AU-rich regions of the 3'-untranslated region of the mRNAs, we verified the nucleotide sequence of human AT(1...

journal_title：Biochemical and biophysical research communications

authors： Pende A,Giacchè M,Castigliola L,Contini L,Passerone G,Patrone M,Port JD,Lotti G

更新日期：1999-12-20 00:00:00

abstract：:Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous infla...

journal_title：Biochemical and biophysical research communications

authors： Li N,Cao M,Yi S,Cheng J,Wang L,Tao Y,Wu D,Peng J,Zhang M,Qi P,Zhao J

更新日期：2018-01-08 00:00:00

abstract：:The present study was designed to clarify the cellular localization and expression of leptin receptor(s) [OB-R(s)] mRNA including its splice variants and their correlation with the cells which secrete placental hormone, placental lactogen-II (PL-II), in rat placentae. By in situ hybridization analysis, hybridization s...

journal_title：Biochemical and biophysical research communications

authors： Kawai M,Murakami T,Otani S,Shima K,Yamaguchi M,Kishi K

更新日期：1999-04-13 00:00:00

abstract：:Unc104/KIF1A, a kinesin family member, is reported to be monomeric in solution, though its polypeptide has regions that potentially form coiled coils. For a better understanding of the mechanism underlying Unc104/KIF1A's motility, it is important to evaluate the dimerization ability of this protein. The CD measurement...

journal_title：Biochemical and biophysical research communications

authors： Shimizu Y,Morii H,Arisaka F,Tanokura M

更新日期：2005-11-25 00:00:00

abstract：BACKGROUND:Statins have been reported to have anti-carcinogenic properties in addition to their cholesterol-lowering effects, but the mechanism is unknown. Thioredoxin reductases (TrxR) are selenium-containing enzymes of great importance for carcinogenesis and their levels are increased in neoplastic cells. The aim of ...

journal_title：Biochemical and biophysical research communications

authors： Skogastierna C,Johansson M,Parini P,Eriksson M,Eriksson LC,Ekström L,Björkhem-Bergman L

更新日期：2012-01-20 00:00:00

abstract：:In this investigation, the activities of five enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-dehydrogenase) involved in oxygen radical (OR)-detoxification and antioxidative defense were measured in conjunction with an index of lipid peroxidation in major prostatic lob...

journal_title：Biochemical and biophysical research communications

authors： Ghatak S,Ho SM

更新日期：1996-05-15 00:00:00

abstract：:Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baica...

journal_title：Biochemical and biophysical research communications

authors： Xiao T,Cui Y,Ji H,Yan L,Pei D,Qu S

更新日期：2021-01-01 00:00:00

abstract：:There is a common mechanism for mechanotransduction in cells, regardless of the cell type. Integrins, interacting with their matrix/environment, mediate increases in intracellular Ca2+ levels and activate MAP kinase cascades to cause ERK1/2 phosphorylation. Phosphorylated ERK1/2 causes the activation of the AP-1 famil...

journal_title：Biochemical and biophysical research communications

authors： Iqbal J,Zaidi M

更新日期：2005-03-18 00:00:00

abstract：:EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investiga...

journal_title：Biochemical and biophysical research communications

authors： Bernsteiner H,Bründl M,Stary-Weinzinger A

更新日期：2017-02-26 00:00:00

abstract：:The calmodulin and C-kinase antagonists melittin, calmidazolium, N-(6-aminohexyl)-5-chloro-1-napthalenesulfonamide (W7), and trifluoperazine (TFP) also inhibit the activity of the human erythrocyte Ca2+-dependent protease, calpain I. W-5, the nonchlorinated derivative of W-7, was ineffective as an inhibitor of calpain...

journal_title：Biochemical and biophysical research communications

authors： Brumley LM,Wallace RW

更新日期：1989-03-31 00:00:00

abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Fukuda S,Tai HH

更新日期：1983-09-15 00:00:00

abstract：:We have obtained the optimized geometrical structure of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium dipolar ion and investigated its geometric and electric changes during decarboxylation process by the MNDO-PM3 method, a molecular orbital method. The salient features of the optimized structure are that the dih...

journal_title：Biochemical and biophysical research communications

authors： Nakajima Y,Sakagishi Y,Shiibashi M,Suzuki Y,Kato H

更新日期：1993-08-31 00:00:00

abstract：:Epidemiological and experimental data suggest a role for polyunsaturated fatty acids in the etiology of breast cancer. In this report we have studied arachidonic acid and linoleic acid metabolism in the human breast carcinoma cell line BT-20 which overexpresses both EGF receptor and the homologous erbB-2 oncogene prod...

journal_title：Biochemical and biophysical research communications

authors： Reddy N,Everhart A,Eling T,Glasgow W

更新日期：1997-02-03 00:00:00

abstract：:Gliomas are the leading cause of death among adults with primary brain malignancies. Treatment for malignant gliomas remains limited, and targeted therapies have been incompletely explored. Nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription regulator for antioxidant and detoxification enzymes, is ...

journal_title：Biochemical and biophysical research communications

authors： Jia Y,Wang H,Wang Q,Ding H,Wu H,Pan H

更新日期：2016-01-15 00:00:00

abstract：:We have recently reported that synthetic peptide amides corresponding to regions of human FSH beta-subunit, hFSH-beta-(33-53) and hFSH-beta-(81-95), bind to receptor and stimulate estradiol biosynthesis by cultured rat Sertoli cells. Because of experimental difficulties caused by the presence of free sulfhydryl groups...

journal_title：Biochemical and biophysical research communications

authors： Grasso P,Crabb JW,Reichert LE Jr

更新日期：1993-01-15 00:00:00

abstract：:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. Howev...

journal_title：Biochemical and biophysical research communications

authors： Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

更新日期：2021-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) stimulates macrophages by activating NF-kappaB, which contributes to the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. 1,5-Anhydro-D-fructose (1,5-AF), a monosaccharide formed from starch and glycogen, exhibits anti-oxidant activity and enhances insulin secretion. This s...

journal_title：Biochemical and biophysical research communications

authors： Meng X,Kawahara K,Nawa Y,Miura N,Shrestha B,Tancharoen S,Sameshima H,Hashiguchi T,Maruyama I

更新日期：2009-03-06 00:00:00

abstract：:Apoptin, a small protein encoded by chicken anemia virus (CAV), induces cell death specifically in cancer cells. In normal cells, Apoptin remains in the cytoplasm; whereas in cancerous cells, it migrates into the nucleus and kills the cell. Cellular localization appears to be crucial. Through a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Huo DH,Yi LN,Yang J

更新日期：2008-07-18 00:00:00

abstract：:The pancreatic islets of Langerhans produce several peptide hormones, predominantly the metabolically active hormones insulin and glucagon, which are critical for maintaining normal fuel homeostasis. Some evidence exists that pancreatic endocrine cells turn over at a slow rate and can regenerate in certain conditions....

journal_title：Biochemical and biophysical research communications

authors： Hunziker E,Stein M

更新日期：2000-04-29 00:00:00

abstract：:TESK1 (testis-specific protein kinase 1) is a serine/threonine kinase, with a unique structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain. Northern blot analysis revealed that TESK1 mRNA is predominantly expressed in testicular germ cells. We present here evidence that express...

journal_title：Biochemical and biophysical research communications

authors： Toshima J,Koji T,Mizuno K

更新日期：1998-08-10 00:00:00

abstract：:Aggregation of the amyloid beta (Abeta) peptide yields both fibrillar precipitates and soluble oligomers, and is associated with Alzheimer's disease (AD). In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation. However, less is known about their interactions with the soluble oligomers, which are...

journal_title：Biochemical and biophysical research communications

authors： Garai K,Sengupta P,Sahoo B,Maiti S

更新日期：2006-06-23 00:00:00

abstract：:Low temperatures cause cellular damage in flower buds of the sweet cherry (Prunus avium L. cv. Satohnishiki). In this study, the redox states within the cherry buds suffering freezing damage were non-destructively observed by a unique in vivo electron spin resonance (ESR) technique with a spin probe such as carbamoyl-...

journal_title：Biochemical and biophysical research communications

authors： Tada M,Shiraishi T,Takashina T,Ohya H,Ogata T

更新日期：2003-10-10 00:00:00

abstract：:Bacillus thuringiensis var. israelensis produces 130 kDa delta-endotoxin which is highly toxic to mosquito-larvae. The mosquito-larvicidal activity was delineated by sequential deletions from ends of the 1136 amino acids delta-endotoxin. A maximum of 459 amino acids could be removed from the carboxy-terminal of the to...

journal_title：Biochemical and biophysical research communications

authors： Pao-intara M,Angsuthanasombat C,Panyim S

更新日期：1988-05-31 00:00:00

abstract：:Focal adhesion kinase, FAK, is a unique protein tyrosine kinase found in cellular focal adhesions. It is widely expressed and highly phosphorylated during embryogenesis. To examine the function of FAK in cell differentiation, we made FAK-deficient embryonic stem (ES) cells by homologous recombination. However, FAK-def...

journal_title：Biochemical and biophysical research communications

authors： Ilic D,Furuta Y,Suda T,Atsumi T,Fujimoto J,Ikawa Y,Yamamoto T,Aizawa S

更新日期：1995-04-06 00:00:00

abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

journal_title：Biochemical and biophysical research communications

authors： Omkumar RV,Gaikwad AS,Ramasarma T

更新日期：1992-05-15 00:00:00

abstract：:Members of the RNase E/G family are multimeric, 5'-end-sensing, single-strand-specific endoribonucleases that are found in chloroplasts as well as bacteria, and have central roles in RNA processing and degradation. A well-studied member of this family is Escherichia coli RNase G. Recently, we have shown that the inter...

journal_title：Biochemical and biophysical research communications

authors： Jourdan SS,Kime L,McDowall KJ

更新日期：2010-01-01 00:00:00