Abstract:
:TESK1 (testis-specific protein kinase 1) is a serine/threonine kinase, with a unique structure composed of an N-terminal protein kinase domain and a C-terminal proline-rich domain. Northern blot analysis revealed that TESK1 mRNA is predominantly expressed in testicular germ cells. We present here evidence that expression of TESK1 mRNA and protein in the rat testes is developmentally regulated and increases after 20-22 postnatal days. To identify cells which express TESK1 mRNA and protein during male germ cell differentiation, in situ hybridization and immunohistochemistry were done using frozen sections of adult rat testes. Prominent expression of TESK1 mRNA and protein was detected in testicular germ cells at stages of late pachytene spermatocytes to round spermatids, but not in somatic cells such as Sertoli and Leydig cells. Expression of TESK1 mRNA and protein at specific stages of testicular germ cells suggests a role for this kinase in spermatogenesis, particularly at stages of meiosis and/or early spermiogenesis.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Toshima J,Koji T,Mizuno Kdoi
10.1006/bbrc.1998.9099subject
Has Abstractpub_date
1998-08-10 00:00:00pages
107-12issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(98)99099-4journal_volume
249pub_type
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2012.06.063
更新日期:2012-07-20 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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更新日期:2007-12-07 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.1997.8026
更新日期:1998-01-26 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.bbrc.2008.12.129
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.1995.2350
更新日期:1995-09-25 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.1996.0236
更新日期:1996-02-15 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2008.09.024
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.2000.2178
更新日期:2000-02-16 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/0006-291x(84)90913-6
更新日期:1984-10-15 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/s0006-291x(86)80224-8
更新日期:1986-12-15 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/s0006-291x(84)80368-x
更新日期:1984-11-30 00:00:00
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doi:10.1016/s0006-291x(03)01284-1
更新日期:2003-08-08 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2010.01.086
更新日期:2010-02-26 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/s0006-291x(05)81561-x
更新日期:1992-08-14 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2006.11.079
更新日期:2007-01-19 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.2001.5227
更新日期:2001-07-20 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/0006-291x(91)91035-b
更新日期:1991-08-15 00:00:00
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journal_title:Biochemical and biophysical research communications
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更新日期:2007-11-30 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/s0006-291x(89)80057-9
更新日期:1989-01-31 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
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更新日期:2010-06-04 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2009.02.155
更新日期:2009-04-24 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1006/bbrc.1993.1426
更新日期:1993-04-30 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2011.12.073
更新日期:2012-01-20 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/s0006-291x(83)80043-6
更新日期:1983-09-30 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2003.10.091
更新日期:2003-11-28 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/j.bbrc.2015.02.120
更新日期:2015-05-01 00:00:00
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journal_title:Biochemical and biophysical research communications
pub_type: 杂志文章
doi:10.1016/0006-291x(83)91561-9
更新日期:1983-11-30 00:00:00