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Flavonoids as scavengers of nitric oxide radical.

Abstract：

:Flavonoids are a group of naturally occurring compounds used, e.g., in the treatment of vascular endothelial damage. They are known to be excellent scavengers of oxygen free radicals. Since the nitric oxide radical (.NO) probably plays a role in this pathology, the .NO scavenging capacity of the flavonoids was determined. It was found that the flavonoids are very potent .NO scavengers. The anthocyanidins were found to be more effective scavengers than the hydroxyethylrutosides, which correlated with their therapeutic activity. The values of their scavenging rate constants are only 30 times less active than the very potent endogenous .NO scavenger haemoglobin. It is speculated that .NO scavenging plays a role in the therapeutic effect of the flavonoids.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

van Acker SA,Tromp MN,Haenen GR,van der Vijgh WJ,Bast A

doi

10.1006/bbrc.1995.2350

subject

Has Abstract

pub_date

1995-09-25 00:00:00

pages

755-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X85723509

journal_volume

214

pub_type

杂志文章

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