Osteoclastic activity induces osteomodulin expression in osteoblasts.

abstract：:Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic reticulum (ER) via the inositol 1, 4, 5-trisphosphate receptor (IP3R)...

journal_title：Biochemical and biophysical research communications

authors： Sakuragi S,Niwa F,Oda Y,Mikoshiba K,Bannai H

更新日期：2017-05-13 00:00:00

abstract：:Vascular endothelial cell (VEC) apoptosis takes part in the development of various cardiovascular diseases. Heat shock protein 90 (HSP90) regulates apoptosis through various apoptosis associated client proteins. In previous study, we identified a novel HSP90 inhibitor HCP1 induced apoptosis in A549 human lung cancer c...

journal_title：Biochemical and biophysical research communications

authors： Wei Q,Zhang J,Su L,Zhao X,Zhao B,Miao J,Lin Z

更新日期：2019-03-26 00:00:00

abstract：:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

更新日期：2014-08-22 00:00:00

abstract：:The p21(WAF-1) promoter contains binding sites for a number of transcription factors which mediate its activation by a variety of external signals. Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in diffe...

journal_title：Biochemical and biophysical research communications

authors： Schavinsky-Khrapunsky Y,Huleihel M,Aboud M,Torgeman A

更新日期：2003-05-16 00:00:00

abstract：:Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to norm...

journal_title：Biochemical and biophysical research communications

authors： Miñana MD,Felipo V,Grisolía S

更新日期：1988-06-30 00:00:00

abstract：:This study presents a kinetic analysis of the response to wounding in rice plants. In particular, jasmonic acid, salicylic acid, and lipoxygenase activity were measured in leaves of wounded rice plants during the early tillering phase. The results show that endogenous jasmonic acid transiently increases to a maximum 3...

journal_title：Biochemical and biophysical research communications

authors： Lee A,Cho K,Jang S,Rakwal R,Iwahashi H,Agrawal GK,Shim J,Han O

更新日期：2004-06-04 00:00:00

abstract：:Lecithin-cholesterol acyltransferase (LCAT) is responsible for the formation of cholesterol esters in plasma and is implicated in the removal of excess cholesterol from peripheral tissues. It is generally accepted that the catalytic mechanism of LCAT is similar to that of serine proteases and lipases involving a Ser, ...

journal_title：Biochemical and biophysical research communications

authors： Adimoolam S,Lee YP,Jonas A

更新日期：1998-02-13 00:00:00

abstract：:Sulfate plays an essential role in human growth and development. Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure. Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent tr...

journal_title：Biochemical and biophysical research communications

authors： Markovich D,Regeer RR,Kunzelmann K,Dawson PA

更新日期：2005-01-28 00:00:00

abstract：:Polypeptide elongation factor 2 (EF-2) plays an essential role in protein synthesis and is believed to be indispensable for cell proliferation. Recently, it has been demonstrated that there are two kinds of EF-2 (EF-2A and EF-2B with 76.6% of sequence identity at the amino acid level) in Dictyostelium discoideum. Alth...

journal_title：Biochemical and biophysical research communications

authors： Yoshino T,Maeda Y,Amagai A

更新日期：2007-08-03 00:00:00

abstract：:The influence of collagen as an effective substitute for gelatin was investigated on properties of chitosan/gelatin hydrogels for fibroblasts growth and attachment for wound dressing applications. We synthesized hydrogels based on chitosan associated with collagen and gelatin biopolymers (in the ratio of 1:5 and 1:1, ...

journal_title：Biochemical and biophysical research communications

authors： Mousavi S,Khoshfetrat AB,Khatami N,Ahmadian M,Rahbarghazi R

更新日期：2019-10-22 00:00:00

abstract：:Application of landscape theory and the dehydron hypothesis to a crystal structure of a G85R mutant superoxide dismutase (SOD1) tetrameric complex allows for the description of a prion-like hypothesis that serves to explain propagated SOD1 misfolding. We have developed two conformational-change scenarios, one local to...

journal_title：Biochemical and biophysical research communications

authors： Healy EF

更新日期：2016-09-30 00:00:00

abstract：:Resistin is an adipokine related to obesity and insulin resistance. Expression of the resistin gene is repressed by the treatment of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, thiazolidinediones (TZDs). In this study, we investigated the mechanism by which TZDs inhibit the resistin gene exp...

journal_title：Biochemical and biophysical research communications

authors： Chung SS,Choi HH,Cho YM,Lee HK,Park KS

更新日期：2006-09-15 00:00:00

abstract：:Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ERα mouse line that can be used to knock out ERα in selected tissues by using the Cre/LoxP system. In this study, we established a...

journal_title：Biochemical and biophysical research communications

authors： Antonson P,Omoto Y,Humire P,Gustafsson JÅ

更新日期：2012-08-10 00:00:00

abstract：:The cytosolic protein synaphin/complexin critically regulates fast neurotransmitter release at the synapse by binding to SNARE complex. However, the exact mechanism of its action remains unclear, and very little is known about how it is physiologically regulated. Here we show that synaphins (Syps) 1 and 2 can be phosp...

journal_title：Biochemical and biophysical research communications

authors： Shata A,Saisu H,Odani S,Abe T

更新日期：2007-03-16 00:00:00

abstract：:To understand the regulation by thyroid hormone, 3,3',5-triiodo-L-thyronine (T3), of the synthesis of a cytosolic thyroid hormone binding protein (p58-M2) during liver regeneration, the synthesis of p58-M2 was evaluated. The synthesis of p58-M2 was measured by metabolic labeling of primary cultures derived from the re...

journal_title：Biochemical and biophysical research communications

authors： Obata T,Cheng SY

更新日期：1992-11-30 00:00:00

abstract：:Previous studies have shown that high-fat diet (HFD)-induced obesity increases the acetoacetyl-CoA synthetase (AACS) gene expression in lipogenic tissue. To investigate the effect of obesity on the AACS gene in other tissues, we examined the alteration of AACS mRNA levels in HFD-fed mice. In situ hybridization reveale...

journal_title：Biochemical and biophysical research communications

authors： Yamasaki M,Hasegawa S,Imai M,Takahashi N,Fukui T

更新日期：2016-04-29 00:00:00

abstract：:In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote fibroblast proliferation, its pathophysiological effects in cardiac myocytes remain to be elucidated. In this study, we examined the biological effects of CTGF in ra...

journal_title：Biochemical and biophysical research communications

authors： Hayata N,Fujio Y,Yamamoto Y,Iwakura T,Obana M,Takai M,Mohri T,Nonen S,Maeda M,Azuma J

更新日期：2008-05-30 00:00:00

abstract：:Genetic mutation is one of the causative factors for idiopathic progressive hearing loss. A patient with late-onset, moderate, and high-frequency hearing loss was found to have a novel, heterozygous KCNQ4 mutation, c.806_808delCCT, which led to a p.Ser260del located between S5 and the pore helix (PH). Molecular modeli...

journal_title：Biochemical and biophysical research communications

authors： Watabe T,Matsunaga T,Namba K,Mutai H,Inoue Y,Ogawa K

更新日期：2013-03-15 00:00:00

abstract：:Human neutrophil cathepsin G and human skin chymase can inactivate bradykinin by cleavage at the carboxy terminal phenylalanyl-arginyl peptide bond of this polypeptide. The mast cell enzyme is far more effective than cathepsin G, the rates of hydrolysis being comparable to that found for angiotensin I to angiotensin I...

journal_title：Biochemical and biophysical research communications

authors： Reilly CF,Schechter NB,Travis J

更新日期：1985-03-15 00:00:00

abstract：:The effects of arachidonic acid on the enzyme complexes in the electron transport system were investigated using submitochondrial particles from rat brain. Arachidonic acid irreversibly inhibited NADH-CoQ oxidoreductase (complex I) activity, but had no effect on the activities of succinate-CoQ oxidoreductase (complex ...

journal_title：Biochemical and biophysical research communications

authors： Morii H,Takeuchi Y,Watanabe Y

更新日期：1991-08-15 00:00:00

abstract：:Transgenic (TG) mice expressing porcine GH receptor (pGHR) directed by a 762-bp proximal leptin promoter were used to analyze the capability of the promoter to drive and regulate pGHR expression in vivo. Transgene expression occurred in inguinal, retroperitoneal, and epididymal/parametrial fat depots in both male and ...

journal_title：Biochemical and biophysical research communications

authors： Chen XL,Hartzell DL,McGraw RA,Hausman GJ,Dean RG

更新日期：1999-08-19 00:00:00

abstract：:Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found in cerebral hemispheres, where, at 164 nmol/g (8.4% of the total aspartic acid), the level of D-aspartic acid exceeds that o...

journal_title：Biochemical and biophysical research communications

authors： Dunlop DS,Neidle A,McHale D,Dunlop DM,Lajtha A

更新日期：1986-11-26 00:00:00

abstract：:TREK1 is a member of the tandem-P domain K+ channel family which is expressed almost exclusively in the nervous system. It is modulated by a number of important factors including arachidonic acid and cell swelling. Since both factors are associated with brain ischemia, it has been suggested that activation of TREK1 ma...

journal_title：Biochemical and biophysical research communications

authors： Miller P,Kemp PJ,Peers C

更新日期：2005-06-17 00:00:00

abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

journal_title：Biochemical and biophysical research communications

authors： Margulis A,Pozdnyakov N,Sitaramayya A

更新日期：1996-01-05 00:00:00

abstract：:Differential expression of nuclear factors binding specifically to AP-1, AP-2, AP-3, and NF-I/CTF enhancer elements was found in the various cell types of human lung carcinoma cells. Adenocarcinoma and squamous carcinoma cells seemed to express higher levels of these factors than large-cell carcinoma and small-cell ca...

journal_title：Biochemical and biophysical research communications

authors： Wong YC,Bernal SD

更新日期：1991-10-31 00:00:00

abstract：:Multiple types of connexin (Cxs) products, including Cx26, Cx30, Cx31, and Cx43, are found by immunolabeling in the mature cochlea. The transcript of Cx29, a newly discovered member of Cx gene family, was also discovered in the cochlea by cDNA macroarray hybridization. However, the functional roles of Cx29 in the coch...

journal_title：Biochemical and biophysical research communications

authors： Yang JJ,Liao PJ,Su CC,Li SY

更新日期：2005-12-16 00:00:00

abstract：:The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide bind...

journal_title：Biochemical and biophysical research communications

authors： Vihinen M,Nilsson L,Smith CI

更新日期：1994-12-15 00:00:00

abstract：:Heme oxygenase-1, an essential enzyme in heme catabolism, and metallothionein IIA, a small metal-binding protein with clusters of cysteins, are remarkably induced in HeLa cells following the treatment with cadmium or zinc. Both proteins are considered to be involved in the defense system against metal toxicity. Here w...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Fujita H,Shibahara S

更新日期：1995-02-06 00:00:00

abstract：:miR-183 cluster, composed of miR-183/-96/-182 genes, is highly expressed in the adult retina, particularly in photoreceptors. It involves in development, maturation and normal function of neuroretina. Ectopic overexpression of miR-183/-96/-182 genes was performed to assess reprogramming of hRPE cells. They were amplif...

journal_title：Biochemical and biophysical research communications

authors： Davari M,Soheili ZS,Samiei S,Sharifi Z,Pirmardan ER

更新日期：2017-01-29 00:00:00

abstract：:HOX genes are transcription factors that play important roles in body patterning and many cellular processes during embryonic, fetal, and adult development. Given their important function in normal tissues, it is reasonable to assume that abnormal expression of HOX genes in adults could lead to serious diseases such a...

journal_title：Biochemical and biophysical research communications

authors： Lee JY,Kim JM,Jeong DS,Kim MH

更新日期：2018-09-18 00:00:00