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Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma.

Abstract：

:FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-β1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ma C,Peng C,Lu X,Ding X,Zhang S,Zou X,Zhang X

doi

10.1016/j.bbrc.2015.01.067

subject

Has Abstract

pub_date

2015-03-06 00:00:00

pages

234-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00097-2

journal_volume

458

pub_type

杂志文章

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