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Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells.

Abstract：

:Focal adhesion kinase, FAK, is a unique protein tyrosine kinase found in cellular focal adhesions. It is widely expressed and highly phosphorylated during embryogenesis. To examine the function of FAK in cell differentiation, we made FAK-deficient embryonic stem (ES) cells by homologous recombination. However, FAK-deficiency did not interfere with differentiation of the ES cells into cells of three germ layers when implanted subcutaneously into nude mice or when treated with retinoic acid in vitro, nor was there any evidence of defects in hematopoiesis in vitro.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ilic D,Furuta Y,Suda T,Atsumi T,Fujimoto J,Ikawa Y,Yamamoto T,Aizawa S

doi

10.1006/bbrc.1995.1503

subject

Has Abstract

pub_date

1995-04-06 00:00:00

pages

300-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71503-3

journal_volume

209

pub_type

杂志文章

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