Abstract:
:Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Ishizuka J,Beauchamp RD,Evers BM,Townsend CM Jr,Thompson JCdoi
10.1016/0006-291x(92)91663-bsubject
Has Abstractpub_date
1992-06-15 00:00:00pages
577-81issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(92)91663-Bjournal_volume
185pub_type
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