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Stimulation of growth of human breast cancer cell lines in culture by linoleic acid.

Abstract：

:Linoleic acid, an omega-6 unsaturated fatty acid, stimulated growth of the MDA-MB-231 and MCF-7 human breast cancer cell lines in culture. Responses of the estrogen-independent MDA-MB-231 cells both in serum-free medium and with 1% fetal bovine serum added were positively correlated with linoleic acid concentration over the entire range examined (5-750 ng/ml). Growth stimulation of the estrogen-responsive MCF-7 cell line was maximal at a LA concentration of 500 ng/ml when cultured in 1% fetal bovine serum-containing medium with added estradiol. Linoleic acid had no mitogenic effect on three human cancer cell lines derived from sites other than breast, or on untransformed 3T3 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rose DP,Connolly JM

doi

10.1016/0006-291x(89)91714-2

subject

Has Abstract

pub_date

1989-10-16 00:00:00

pages

277-83

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91714-2

journal_volume

164

pub_type

杂志文章

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