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Identification of angiotensin II receptor subtypes.

Abstract：

:We have demonstrated the existence of two distinct subtypes of the angiotensin II receptor in the rat adrenal gland using radioligand binding and tissue section autoradiography. The identification of the subtypes was made possible by the discovery of two structurally dissimilar, nonpeptide compounds, DuP 753 and EXP655, that show reciprocal selectivity for the two subtypes. In the rat adrenal cortex, DuP 753 inhibited 80% of the total AII binding with an IC50 value on the sensitive sites of 2 x 10(-8) M, while EXP655 displaced only 20%. In the rat adrenal medulla, EXP655 gave 90% inhibition of AII binding with an IC50 value of 3.0 x 10(-8) M, while DuP 753 was essentially inactive. The combination of the two compounds completely inhibited AII binding in both tissues.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chiu AT,Herblin WF,McCall DE,Ardecky RJ,Carini DJ,Duncia JV,Pease LJ,Wong PC,Wexler RR,Johnson AL

doi

10.1016/0006-291x(89)91054-1

subject

Has Abstract,Author List Incomplete

pub_date

1989-11-30 00:00:00

pages

196-203

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)91054-1

journal_volume

165

pub_type

杂志文章

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