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Head/tail interaction of vinculin influences cell mechanical behavior.

Abstract：

:This study evaluates the influence of vinculin in closed conformation on the mechanical properties of cells. We demonstrate that MEFvin(-/-) cells transfected with the eGFP-vinculin mutant A50I (talin-binding-deficient-vinculin in a constitutively closed conformation) show 2-fold lower stiffness and focal adhesion density compared to MEFvin(+/+) and MEF(Rescue) cells. MEF(A50I) cells are as stiff as MEFvin(-/-) cells with similar focal adhesion density. Further, 2D traction microscopy indicates that MEF(A50I) and MEFvin(-/-) cells generate 3- to 4-fold less strain energy than MEFvin(+/+) and MEF(Rescue) cells. These results demonstrate that vinculin's mechano-coupling function is dependent on its conformational state.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Diez G,Auernheimer V,Fabry B,Goldmann WH

doi

10.1016/j.bbrc.2011.01.115

subject

Has Abstract

pub_date

2011-03-04 00:00:00

pages

85-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00167-7

journal_volume

406

pub_type

杂志文章

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