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Cloning of SEZ-12 encoding seizure-related and membrane-bound adhesion protein.

Abstract：

:SEZ-12 is one of the seizure-related cDNAs which was isolated by differential hybridization from primary cultured neurons from the mouse cerebral cortex with or without pentylenetetrazol (PTZ). SEZ-12 expression is transiently down-regulated in the mouse brain by injection of PTZ. To characterize SEZ-12, isolation of full-length cDNA and nucleotide sequence analysis were performed. The deduced amino acid sequence of SEZ-12 revealed that it encodes membrane-bound C-type lectin and has a significant homology to that of human cDNA, DGCR2 and IDD, which were cloned from a balanced translocation breakpoint associated with the DiGeorge syndrome. The isolated cDNA was about 4 kb in length and the message was expressed ubiquitously in various organs with low-abundance. Previously, we also cloned a transmembrane protein which is probably involved in cell-cell interaction by the differential hybridization technique. These findings suggest that transmembrane signaling in neuronal cells may have an important role in PTZ-induced seizure.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kajiwara K,Nagasawa H,Shimizu-Nishikawa K,Ookura T,Kimura M,Sugaya E

doi

10.1006/bbrc.1996.0712

subject

Has Abstract

pub_date

1996-05-06 00:00:00

pages

144-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)90712-3

journal_volume

222

pub_type

杂志文章

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