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Presence of centrin in the human parasite Giardia: a further indication of its ubiquity in eukaryotes.

Abstract：

:The presence and distribution of the cytoskeletal protein centrin in the lower eukaryote Giardia were determined using a monoclonal antibody to algal centrin. Immunofluorescence shows that centrin is a major component of rodlike structures associated with the flagella and strongly attached to the ventral disc and the 2 nuclei. Two groups of spots are also highlighted at the top of each nucleus where the basal bodies are situated. Western blot analysis revealed a single 23-kDa polypeptide. These findings support the ubiquity of centrin and its ancient evolutionary origin and also underline cytoskeleton complexity of Giardia, the reportedly most primitive eukaryotic organism known.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Belhadri A

doi

10.1006/bbrc.1995.2327

subject

Has Abstract

pub_date

1995-09-14 00:00:00

pages

597-601

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72327-3

journal_volume

214

pub_type

杂志文章

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