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Loss of alpha I type I collagen gene expression in rat clonal bone cell lines is accompanied by DNA methylation.

Abstract：

:Four clonal cell lines subcloned from a clonal population of fetal rat calvaria cells show a loss of type I collagen synthesis. Northern blot analysis showed that the level of alpha 1(I) collagen mRNA expression in each of the clonal populations parallels the level of collagen protein expression in each of these cell lines. The methylation pattern of the collagen gene in these clonal cell lines was determined using the restriction endonucleases MspI and HpaII. It was found that the loss in collagen type I expression correlated positively with the degree of methylation of alpha 1(I) procollagen genes, indicating that methylation of CpG may be an important mechanism of collagen gene regulation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Waye MM,Robinson R,Orfanides AG,Aubin JE

doi

10.1016/0006-291x(89)90836-x

subject

Has Abstract

pub_date

1989-08-15 00:00:00

pages

1446-52

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)90836-X

journal_volume

162

pub_type

杂志文章

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