Loss of alpha I type I collagen gene expression in rat clonal bone cell lines is accompanied by DNA methylation.

abstract：:Differential expression of nuclear factors binding specifically to AP-1, AP-2, AP-3, and NF-I/CTF enhancer elements was found in the various cell types of human lung carcinoma cells. Adenocarcinoma and squamous carcinoma cells seemed to express higher levels of these factors than large-cell carcinoma and small-cell ca...

journal_title：Biochemical and biophysical research communications

authors： Wong YC,Bernal SD

更新日期：1991-10-31 00:00:00

abstract：:Eosinophil cationic protein (ECP) is a toxin secreted by activated human eosinophils. The properties of mature ECP have been well studied but those of the signal peptide of ECP (ECPsp) are not clear. In this study, several chimeric proteins containing N-terminal fusion of ECPsp were generated, and introduced into Esch...

journal_title：Biochemical and biophysical research communications

authors： Wu CM,Chang MD

更新日期：2004-09-17 00:00:00

abstract：:The correlation between genomic G+C content and optimal growth temperature in prokaryotes has gained renewed interest after Musto et al. [H. Musto, H. Naya, A. Zavala, H. Romero, F. Alvarex-Valin, G. Bernardi, Correlations between genomic GC levels and optimal growth temperatures in prokaryotes, FEBS Lett. 573 (2004) ...

journal_title：Biochemical and biophysical research communications

authors： Wang HC,Susko E,Roger AJ

更新日期：2006-04-14 00:00:00

abstract：:To date, tick-borne flaviviruses responsible for hemorrhagic fever in humans have been isolated in Siberia (Omsk hemorrhagic fever virus), India (Kyasanur Forest disease virus, KFDV), and in Saudi Arabia (Alkhurma virus, ALKV). Prior to this study, only partial coding sequences of these severe pathogens had been deter...

journal_title：Biochemical and biophysical research communications

authors： Charrel RN,Zaki AM,Attoui H,Fakeeh M,Billoir F,Yousef AI,de Chesse R,De Micco P,Gould EA,de Lamballerie X

更新日期：2001-09-21 00:00:00

abstract：:Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating ...

journal_title：Biochemical and biophysical research communications

authors： Duarte M,Kolev V,Soldi R,Kirov A,Graziani I,Oliveira SM,Kacer D,Friesel R,Maciag T,Prudovsky I

更新日期：2006-11-24 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

journal_title：Biochemical and biophysical research communications

authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

更新日期：2017-01-22 00:00:00

abstract：:Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewid...

journal_title：Biochemical and biophysical research communications

authors： Mao XQ,Kawai M,Yamashita T,Enomoto T,Dake Y,Sasaki S,Kataoka Y,Fukuzumi T,Endo K,Sano H,Aoki T,Kurimoto F,Adra CN,Shirakawa T,Hopkin JM

更新日期：2000-09-24 00:00:00

abstract：:This study evaluates intracellular cAMP concentrations, in interleukin-1 (IL-1) mediated cytostasis of K562 cells. Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells. IL-1 was found to elicit a dose-dependent rise in adenyl c...

journal_title：Biochemical and biophysical research communications

authors： Weitzmann MN,Savage N

更新日期：1993-01-29 00:00:00

abstract：:Using different maximum-likelihood models of adaptive evolution, signatures of natural selective pressure, operating across the naphthalene family of dioxygenases, were examined. A lineage- and branch-site specific combined analysis revealed that purifying selection pressure dominated the evolutionary history of the e...

journal_title：Biochemical and biophysical research communications

authors： Dutta A,Chakraborty J,Dutta TK

更新日期：2013-10-11 00:00:00

abstract：:MicroRNAs are involved in cancer-related processes. The microRNA-21(miR-21) has been identified as the only miRNA over-expressed in a wide variety of cancers, including cervical cancer. However, the function of miR-21 is unknown in cervical carcinomas. In this study, we found that the inhibition of miR-21 in HeLa cerv...

journal_title：Biochemical and biophysical research communications

authors： Yao Q,Xu H,Zhang QQ,Zhou H,Qu LH

更新日期：2009-10-23 00:00:00

abstract：:RNA-binding proteins are believed to play important roles in regulation of neural functions. Recently, a mouse cDNA encoding the cold-inducible RNA-binding protein, Cirp, has been isolated, the amino acid sequence of which showed similarity to plant circadian rhythm proteins. In the present study, diurnal expression o...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama H,Xue JH,Sato T,Fukuyama H,Mizuno N,Houtani T,Sugimoto T,Fujita J

更新日期：1998-04-17 00:00:00

abstract：:Pyruvate dehydrogenase kinase isoform 4 (PDK4) is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the pyruvate dehydrogenase complex which blocks pyruvate oxidation and conserves lactate and alanine for gluconeogenesis. Enhanced PDK4 expression may be caused by the ...

journal_title：Biochemical and biophysical research communications

authors： Wu P,Peters JM,Harris RA

更新日期：2001-09-21 00:00:00

abstract：:It is well-known that electrical stimulation can prompt healing of bone fractures. However, the mechanism involved is less clear. In this study, we found that capacitively coupled electric field-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of transforming growth factor-beta 1 (TG...

journal_title：Biochemical and biophysical research communications

authors： Zhuang H,Wang W,Seldes RM,Tahernia AD,Fan H,Brighton CT

更新日期：1997-08-18 00:00:00

abstract：:Apoptosis and autophagy are crucial mechanisms regulating cell death, and the relationship between apoptosis and autophagy in the liver has yet to be thoroughly explored. TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ROS (reactive oxygen species...

journal_title：Biochemical and biophysical research communications

authors： Ye L,Zhao X,Lu J,Qian G,Zheng JC,Ge S

更新日期：2013-07-26 00:00:00

abstract：:The Andean potato weevil, Premnotrypes vorax, an insect of the order Coleoptera, is a major cause of damage to potato crops in the Andean regions of South America. The insecticidal Cry proteins from Bacillus thuringiensis are useful biological pesticides, and some are toxic to Coleopteran insects. We overexpressed rec...

journal_title：Biochemical and biophysical research communications

authors： Gomez S,Mateus AC,Hernandez J,Zimmermann BH

更新日期：2000-12-20 00:00:00

abstract：:Phospholipase D has been implicated as an important enzyme in a range of cellular responses, including regulated secretion and the formation of secretory vesicles, cell proliferation and control of cell morphology. As insulin treatment of adipocytes has been shown to stimulate a phosphatidylcholine-specific phospholip...

journal_title：Biochemical and biophysical research communications

authors： Millar CA,Jess TJ,Saqib KM,Wakelam MJ,Gould GW

更新日期：1999-01-27 00:00:00

abstract：:Until now, voltage-gated Ca(2+) channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca(2+) channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in i...

journal_title：Biochemical and biophysical research communications

authors： Durell SR,Guy HR

更新日期：2001-03-02 00:00:00

abstract：:Agmatine, a putative endogenous ligand of imidazoline receptors, suppresses cardiovascular function by inhibiting peripheral sympathetic tone. However, the molecular identity of imidazoline receptor subtypes and its cellular mechanism underlying the agmatine-induced sympathetic suppression remains unknown. Meanwhile, ...

journal_title：Biochemical and biophysical research communications

authors： Kim YH,Jeong JH,Ahn DS,Chung S

更新日期：2016-08-26 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers and is the second-leading cause of cancer-associated morbidity worldwide. Oxysterols are oxidized derivatives of cholesterol that may be important in many biological processes, but the levels and roles of oxysterols in gastric tumours remain to be elucidated. The l...

journal_title：Biochemical and biophysical research communications

authors： Guo F,Hong W,Yang M,Xu D,Bai Q,Li X,Chen Z

更新日期：2018-10-12 00:00:00

abstract：:Keap1 is proposed to be a sensor protein of electrophilic compounds and a transducer of the signal from electrophilic compounds for transcriptional activation. Thus, the use of keap1 gene-knockout (KO) mice is a straightforward approach in order to clarify the molecular background for the use of electrophilies as neur...

journal_title：Biochemical and biophysical research communications

authors： Satoh T,Harada N,Hosoya T,Tohyama K,Yamamoto M,Itoh K

更新日期：2009-03-06 00:00:00

abstract：:The filamentous fungus Aspergillus ochraceus TS produces an inducible microsomal cytochrome P-450 linked monooxygenase which is capable of hydroxylating benzo(a)pyrene in presence of O2 and NADPH. The addition of Benzo(a)pyrene, 3-Methyl cholanthrene, beta-Naphthoflavone and other aryl hydrocarbons during the inductio...

journal_title：Biochemical and biophysical research communications

authors： Dutta D,Ghosh DK,Mishra AK,Samanta TB

更新日期：1983-09-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

journal_title：Biochemical and biophysical research communications

authors： Ladoux A,Frelin C

更新日期：1993-09-15 00:00:00

abstract：:We examined the effects of troglitazone on expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Troglitazone dose-dependently increased expression of E-cadherin and claudin 4 mRNA and protein in PK-1 cells. Snail, Slug and ZEB1, mRNAs were not changed by troglitazone, indicating that these three tr...

journal_title：Biochemical and biophysical research communications

authors： Kumei S,Motomura W,Yoshizaki T,Takakusaki K,Okumura T

更新日期：2009-03-13 00:00:00

abstract：:Incorporation of [3H]-thymidine into DNA in non-synchronized cultures of human endothelial cells was blocked by a 24 h exposure to TNF in a dose dependent manner that resulted in accumulation of cells in G1, as assayed by flow cytometry analysis of DNA content. Proliferation restarted when cells were replated in the a...

journal_title：Biochemical and biophysical research communications

authors： López-Marure R,Bernal AE,Zentella A

更新日期：1997-07-30 00:00:00

abstract：:ABCA1 on the cell surface and in endosomes plays an essential role in the cell-mediated lipidation of apoA-I to form nascent HDL. Our previous studies of transgenic mice overexpressing ABCA1 suggested that ABCA1 in the liver plays a major role in regulating plasma HDL levels. The site of function of ABCA1 in the polar...

journal_title：Biochemical and biophysical research communications

authors： Neufeld EB,Demosky SJ Jr,Stonik JA,Combs C,Remaley AT,Duverger N,Santamarina-Fojo S,Brewer HB Jr

更新日期：2002-10-04 00:00:00

abstract：:The effects of pioglitazone, a novel antidiabetic insulin-sensitizing agent, on insulin signaling in skeletal muscles from genetically obese Wistar fatty rats and their lean littermates were studied. Increased tyrosine phosphorylation levels of insulin receptors (IRs) and insulin receptor substrate 1 (IRS-1) in respon...

journal_title：Biochemical and biophysical research communications

authors： Hayakawa T,Shiraki T,Morimoto T,Shii K,Ikeda H

更新日期：1996-06-14 00:00:00

abstract：:The eukaryotic DNA cytosine-5-methyltransferase (E.C.2.1.1.37) is known to methylate cytosine in DNA mainly, but not exclusively in C-G. In the present study the minor, non-C-G recognition sequences of a rat DNA methyltransferase were analyzed by Maxam-Gilbert sequencing of in vitro methylated SV40 DNA. The enzyme met...

journal_title：Biochemical and biophysical research communications

authors： Hubrich-Kühner K,Buhk HJ,Wagner H,Kröger H,Simon D

更新日期：1989-05-15 00:00:00

abstract：:A 48-h incubation of cultured human fibroblasts with 5 x 10(-5) M oleic acid or polyunsaturated fatty acids (PUFA) from the (n-6) (linoleic, gamma-linolenic and arachidonic acids) or (n-3) (alpha-linolenic and eicosapentaenoic acids) series resulted in an enrichment of the cells with the introduced fatty acid. Cell en...

journal_title：Biochemical and biophysical research communications

authors： Mazière C,Conte MA,Degonville J,Ali D,Mazière JC

更新日期：1999-11-01 00:00:00

abstract：:The question of how eukaryotic cells assemble their mitochondria was long considered to be inaccessible to biochemical investigation. This attitude changed about fifty years ago when the powerful tools of yeast genetics, electron microscopy and molecular biology were brought to bear on this problem. The rising interes...

journal_title：Biochemical and biophysical research communications

authors： Schatz G

更新日期：2013-05-10 00:00:00

abstract：:Myelin basic protein (MBP) has been shown to bind calmodulin (CaM) in a specific Ca(2+)-dependent manner via a primary target sequence at its C-terminus [Protein Sci. 12 (2003) 1507]. Upon deimination of MBP, the nature of the interaction changed significantly, suggesting either a new binding site or different conform...

journal_title：Biochemical and biophysical research communications

authors： Libich DS,Hill CM,Haines JD,Harauz G

更新日期：2003-08-22 00:00:00