Autocrine regulation of the renal arterial tone by adrenomedullin.

abstract：:Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumours including breast cancer (BC). This study aimed to evaluate the clinical and prognostic value of MCTs used by immunohistochemistry and quantum dots-based fluorescent ima...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Wu Q,Sun S,Wu J,Li J,Zhang Y,Wang C,Yuan J,Sun S

更新日期：2018-07-02 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers and has great potential therapeutic value. We show that tigecycline, a FDA-approved antibiotic drug, targets cervical squamous cell carcinoma through inhibiting Wnt/β-catenin signaling pathway. Tigecycline is effective in in...

journal_title：Biochemical and biophysical research communications

authors： Li H,Jiao S,Li X,Banu H,Hamal S,Wang X

更新日期：2015-11-06 00:00:00

abstract：:Interleukin 6 is a pleiotropic cytokine produced in the central nervous system (CNS) that has been involved in both direct neurotrophic activities and in the regulation of the production of acute phase proteins both at peripheral and central levels. In rat cortical type I astrocytes, interleukin 6 release is under the...

journal_title：Biochemical and biophysical research communications

authors： Grimaldi M,Florio T,Schettini G

更新日期：1997-06-09 00:00:00

abstract：:Isovalerylcarnitine, a product of the catabolism of L-leucine, is a potent activator of rat calpains isolated from erythrocytes, kidney, liver, skeletal and heart muscle. Only calpains II, but not calpains I, are activated by IVC, with the only exception of rat erythrocyte calpain I, the only species present in these ...

journal_title：Biochemical and biophysical research communications

authors： Pontremoli S,Melloni E,Viotti PL,Michetti M,Di Lisa F,Siliprandi N

更新日期：1990-02-28 00:00:00

abstract：:A L-delta 1-pyrroline-5-carboxylate reductase activity has been detected in crude extracts of Desulfovibrio desulfuricans Norway. This P5C reductase activity is also found when a 2.5 kb D. desulfuricans DNA fragment is introduced into an Escherichia coli proC mutant. Although it restores growth of the proC mutant, the...

journal_title：Biochemical and biophysical research communications

authors： Fons M,Cami B,Chippaux M

更新日期：1991-09-16 00:00:00

abstract：:Endothelin (200 nM) evoked a rapid rise in [Ca2+]i which was then followed by a maintained elevation of [Ca2+]i. The initial transient can be explained by the release of stored Ca2+ whilst the maintained plateau is likely to be an influx of Ca2+ as it was partially inhibited by nifedipine (5 microM) and the remaining ...

journal_title：Biochemical and biophysical research communications

authors： Simpson AW,Ashley CC

更新日期：1989-09-29 00:00:00

abstract：:The treatment of human platelets with the dibutyryl cyclic AMP (dbcAMP) revealed the presence of a 250 kDa protein which enhanced its GTP-binding activity. This protein was purified from platelet membranes by successive chromatographies on DEAE-cellulose, Ultrogel AcA34, Mono Q, HCA-hydroxyapatite, and TSK-3000SW colu...

journal_title：Biochemical and biophysical research communications

authors： Yada Y,Okano Y,Nozawa Y

更新日期：1990-10-15 00:00:00

abstract：:A protein, with a novel N-terminal amino acid sequence and a molecular mass of 30 kDa, was purified from fresh Smilax glabra rhizomes by adsorption on DEAE-cellulose, CM-cellulose, Con A-Sepharose, and Mono S, and by fast protein liquid chromatography-gel filtration on Superdex 75. The protein, designated as smilaxin,...

journal_title：Biochemical and biophysical research communications

authors： Chu KT,Ng TB

更新日期：2006-02-03 00:00:00

abstract：:Agmatine, a putative endogenous ligand of imidazoline receptors, suppresses cardiovascular function by inhibiting peripheral sympathetic tone. However, the molecular identity of imidazoline receptor subtypes and its cellular mechanism underlying the agmatine-induced sympathetic suppression remains unknown. Meanwhile, ...

journal_title：Biochemical and biophysical research communications

authors： Kim YH,Jeong JH,Ahn DS,Chung S

更新日期：2016-08-26 00:00:00

abstract：:Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increas...

journal_title：Biochemical and biophysical research communications

authors： Nakadate Y,Kodera Y,Kitamura Y,Tachibana T,Tamura T,Koizumi F

更新日期：2013-11-29 00:00:00

abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

journal_title：Biochemical and biophysical research communications

authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

更新日期：2019-07-12 00:00:00

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:Under many physiological circumstances, Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high-affinity choline uptake (HACU) in cholinergic neurons is thought to be rate-limiting in the biosynthesis of acetylcholine (ACh). Based on sequence information provided by the Human Genome Project and the recently...

journal_title：Biochemical and biophysical research communications

authors： Apparsundaram S,Ferguson SM,George AL Jr,Blakely RD

更新日期：2000-10-05 00:00:00

abstract：:Branched-chain alpha-keto acid dehydrogenase (BCKDH) complex catalyzes the committed step of branched-chain amino acid catabolism, and its activity is regulated by the phosphorylation-dephosphorylation cycle. BCKDH kinase is responsible for inactivation of the complex by phosphorylation. In the present study, we exami...

journal_title：Biochemical and biophysical research communications

authors： Xu M,Nagasaki M,Obayashi M,Sato Y,Tamura T,Shimomura Y

更新日期：2001-09-28 00:00:00

abstract：:We have identified a novel reaction in which acetaldehyde promotes rat hepatic cytosolic catalysis of O2 consumption coupled with glutathione oxidation without apparent release of activated forms of O2. Acetaldehyde is not consumed in the reaction. The reaction (O2 consumption or oxidized glutathione production) is sa...

journal_title：Biochemical and biophysical research communications

authors： Lyon I,Kaplowitz N

更新日期：1985-06-28 00:00:00

abstract：:Fanconi anemia (FA) is a genetic disorder characterized by congenital malfunction, bone marrow failure and hypersensitivity to DNA damage. FANCD2 protein play the central role in FA pathway. To study the in vivo role of FANCD2, we generated and characterized a new Fancd2 knockout mouse strain with 7bp deletion in Fanc...

journal_title：Biochemical and biophysical research communications

authors： Yang Q,Xie H,Zhong Y,Li D,Ke X,Ying H,Yu B,Zhang T

更新日期：2019-06-30 00:00:00

abstract：:Cervical cancer is one of the most commonly diagnosed lethal malignancies among gynecological malignant tumors worldwide. Chemo-resistance is one of the key causal factors in cervical cancer death. Osthole (OST), a natural compound, exhibits various pharmacological activities, including anti-tumor effects. However, it...

journal_title：Biochemical and biophysical research communications

authors： Su J,Zhang F,Li X,Liu Z

更新日期：2019-06-25 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00

abstract：:PKN1 is a fatty acid and Rho-activated serine/threonine protein kinase whose catalytic domain is highly homologous to protein kinase C (PKC) family. In yeast two-hybrid screening for PKN1 binding proteins, we identified tumor necrosis factor alpha (TNFalpha) receptor-associated factor 2 (TRAF2). TRAF2 is one of the ma...

journal_title：Biochemical and biophysical research communications

authors： Gotoh Y,Oishi K,Shibata H,Yamagiwa A,Isagawa T,Nishimura T,Goyama E,Takahashi M,Mukai H,Ono Y

更新日期：2004-02-13 00:00:00

abstract：:The NS3 serine protase of Hepatitis C virus (HCV) requires NS4A protein as a cofactor for efficient cleavage at four sites in the nonstructural region. The cofactor activity has been mapped to the central hydrophobic region (aa 22-34) of this 54-amino-acid NS4A protein, and site-directed mutagenesis has identified alt...

journal_title：Biochemical and biophysical research communications

authors： Butkiewicz NJ,Yao N,Wright-Minogue J,Zhang R,Ramanathan L,Lau JY,Hong Z,Dasmahapatra B

更新日期：2000-01-07 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose p...

journal_title：Biochemical and biophysical research communications

authors： Osawa Y,Wang YL,Osaka H,Aoki S,Wada K

更新日期：2001-05-11 00:00:00

abstract：:The yellow locus in Drosophila is involved in both cuticle development and behaviour. However, the function of the encoded protein is unknown. Here we have characterised the sequence and expression pattern of a new Drosophila gene, designated yellow-B, encoding a 453-amino-acid protein that is 57% identical to Yellow....

journal_title：Biochemical and biophysical research communications

authors： Maleszka R,Kucharski R

更新日期：2000-04-21 00:00:00

abstract：:Bryostatin-1 is a natural activator of protein kinase C and currently examined in phase I trials as anticancer agent. We found that Bryostatin-1 induced tumor necrosis factor alpha (TNF alpha) expression in the human cell line MONO-MAC-6. Using Northern blot analysis and a bioassay for the detection of the cytokine we...

journal_title：Biochemical and biophysical research communications

authors： Steube KG,Drexler HG

更新日期：1995-09-25 00:00:00

abstract：:1,25(OH)2D3 receptors were studied in whole testes, Sertoli cells, seminiferous tubules, Leydig cells and spermatogonia of adult NMRI mice and SD rats. Specific reversible high affinity binding (KD 1.4 x 10(-10)M; Nmax 72 fmol/mg protein) by a 3.5 S macromolecule was demonstrated in whole testes, Sertoli cells and sem...

journal_title：Biochemical and biophysical research communications

authors： Merke J,Hügel U,Ritz E

更新日期：1985-02-28 00:00:00

abstract：:Nuclei were isolated from bloodstream forms of Trypanosoma brucei by nitrogen cavitation and sedimentation through percoll density gradients. Transcription studies with these nuclei in vitro demonstrated features not seen with other eukaryotes: RNA synthesis was much greater in the presence of Mn2+ than with Mg2+ and ...

journal_title：Biochemical and biophysical research communications

authors： Earnshaw DL,Beebee TJ,Gutteridge WE

更新日期：1985-09-16 00:00:00

abstract：:The pregnant hog ovary is a rich source of a novel exopeptidase that catalyzes the release, at pH 5.0, of collagen-related (P3-P2-P1) "triplets" such as Gly-Pro-Met, Gly-Pro-Arg, and Gly-Pro-Ala from arylamide derivatives, provided the N termini are unsubstituted. Corresponding derivatives of related (P2-P1) dipeptide...

journal_title：Biochemical and biophysical research communications

authors： McDonald JK,Hoisington AR,Eisenhauer DA

更新日期：1985-01-16 00:00:00

abstract：:The inhibitory effect of sodium selenite on biliary secretion of methyl mercury was examined in rats. The biliary secretion of methyl mercury in rat treated with 1 mumol/kg of methyl mercury was significantly decreased by administration of selenite at doses of 0.05 mumol/kg or higher. In rats given 10 mumol/kg of meth...

journal_title：Biochemical and biophysical research communications

authors： Urano T,Imura N,Naganuma A

更新日期：1997-10-29 00:00:00

abstract：:We have previously reported that the two components of R2TP complex, RNA polymerase II-associated protein 3 (RPAP3), and Reptin, regulate apoptosis. Here we characterize another component of the complex, PIH1 domain containing protein 1 (PIH1D1). PIH1D1 interacts with both RPAP3 and Monad in HEK293 or U2OS cells. PIH1...

journal_title：Biochemical and biophysical research communications

authors： Inoue M,Saeki M,Egusa H,Niwa H,Kamisaki Y

更新日期：2010-12-17 00:00:00

abstract：:Many organisms do not contain the necessary biochemical armoury to carry out the initial oxidative attack of many pollutant chemicals. In the present study, Acinetobacter sp. strain BD413 has been genetically engineered to express the cytochrome P450 xenobiotic-metabolising enzyme CYP105D1 from Streptomyces griseus th...

journal_title：Biochemical and biophysical research communications

authors： Lamb DC,Kelly DE,Masaphy S,Jones GL,Kelly SL

更新日期：2000-09-24 00:00:00

abstract：:VDR regulates gene expression in a ligand-dependent way by binding to cognate enhancer elements of target gene promoters. The ligand-dependent activation function, AF-2, of VDR is thought to require transcriptional co-activators/co-repressors together with basal transcriptional machinery. Using a yeast two hybrid syst...

journal_title：Biochemical and biophysical research communications

authors： Imai T,Matsuda K,Shimojima T,Hashimoto T,Masuhiro Y,Kitamoto T,Sugita A,Suzuki K,Matsumoto H,Masushige S,Nogi Y,Muramatsu M,Handa H,Kato S

更新日期：1997-04-28 00:00:00