Calcium-dependent proteinase activity in root cultures of Arabidopsis.

abstract：:Using a PCR-based cloning strategy we have isolated a cDNA from mouse brain and named it fex, because it codes for a novel putative G protein-coupled receptor expressed in follicles. The deduced amino acid sequence shows a higher degree of homology to the family of glycoprotein receptors, namely those for FSH, LH, and...

journal_title：Biochemical and biophysical research communications

authors： Hermey G,Methner A,Schaller HC,Hermans-Borgmeyer I

更新日期：1999-01-08 00:00:00

abstract：:Structure-function relationships in the 6 epidermal growth factor-like domains of human thrombomodulin (TME, residues 227-462) were studied by deletion mutagenesis. Purified and characterised proteins were used for kinetic studies. Deletion of EGF1, EGF2 and residues 310-332 in EGF3 had no effect on thrombin binding (...

journal_title：Biochemical and biophysical research communications

authors： Parkinson JF,Nagashima M,Kuhn I,Leonard J,Morser J

更新日期：1992-06-15 00:00:00

abstract：:Bovine heart cytochrome c oxidase, depleted of polypeptide subunits by alkaline detergent treatment, was characterized with respect to metal content, optical spectral properties, and oxidase activity. Treatment with 1.0% Triton X-100 at pH 9.5 followed by anion-exchange chromatography caused removal of subunit III, su...

journal_title：Biochemical and biophysical research communications

authors： Yewey GL,Caughey WS

更新日期：1987-11-13 00:00:00

abstract：:Although brain natriuretic peptide (BNP) is a novel natriuretic peptide originally identified in porcine brain, recent investigation has verified the presence of BNP in porcine heart. In order to identify BNP as a circulating hormone, we analyzed the regional distribution and molecular form of immunoreactive (ir-) BNP...

journal_title：Biochemical and biophysical research communications

authors： Aburaya M,Minamino N,Kangawa K,Tanaka K,Matsuo H

更新日期：1989-12-15 00:00:00

abstract：:Molecular chaperones prevent the aggregation of partially folded or misfolded forms of protein. alpha-crystallin performs such a function in the ocular lens. To gain insight into the mechanism of the anti-aggregation activity of alpha-crystallin, we performed dynamic light scattering (DLS) measurements investigating i...

journal_title：Biochemical and biophysical research communications

authors： Bettelheim FA,Ansari R,Cheng QF,Zigler JS Jr

更新日期：1999-08-02 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play important roles in osteoblast differentiation and maturation. In mammals, the BMP-induced receptor-regulated Smads form complexes with Smad4. These complexes translocate and accumulate in the nucleus, where they regulate the transcription of various target genes. However, the fu...

journal_title：Biochemical and biophysical research communications

authors： Shimada K,Ikeda K,Ito K

更新日期：2009-12-18 00:00:00

abstract：:The relation between platelet-derived growth factor (PDGF)-induced smooth muscle cell migration, measured in Boyden chambers, and cellular arachidonic acid cascade was studied by using rat aortic smooth muscle cells. Partially purified PDGF stimulated cell migration significantly at a concentration of 1.33-133.0 micro...

journal_title：Biochemical and biophysical research communications

authors： Nakao J,Ito H,Chang WC,Koshihara Y,Murota S

更新日期：1983-05-16 00:00:00

abstract：:Bcl10 is a signaling protein required for activation of the NF-kappaB transcription factor. NF-kappaB is an important mediator of genotoxic stress and regulates the expression of genes required for both cell proliferation and cell death. Bcl10 is phosphorylated in vivo, however, the protein kinase or kinases responsib...

journal_title：Biochemical and biophysical research communications

authors： Bodero AJ,Ye R,Lees-Miller SP

更新日期：2003-02-21 00:00:00

abstract：:Promyelocytic leukaemia (PML) is a tumor suppressor protein covalently conjugated with SUMO family proteins, leading to the formation of PML nuclear bodies (NBs). PML-NBs provide a platform for efficient posttranslational modification of targets and protein-protein interaction, contributing to the adjustment of gene e...

journal_title：Biochemical and biophysical research communications

authors： Fukuda T,Kigoshi-Tansho Y,Naganuma T,Kazaana A,Okajima T,Tsuruta F,Chiba T

更新日期：2017-01-22 00:00:00

abstract：:In cranial skeletal development, the establishment of the ectomesenchymal lineage within the cranial neural crest is of great significance. Fgfs are polypeptide growth factors with diverse functions in development and metabolism. Fgf20b knockdown zebrafish embryos showed dysplastic neurocranial and pharyngeal cartilag...

journal_title：Biochemical and biophysical research communications

authors： Yamauchi H,Goto M,Katayama M,Miyake A,Itoh N

更新日期：2011-06-17 00:00:00

abstract：:Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c...

journal_title：Biochemical and biophysical research communications

authors： Radding W,Pan ZQ,Hunter E,Johnston P,Williams JP,McDonald JM

更新日期：1996-01-05 00:00:00

abstract：:Cisplatin plays a key role in treating small cell lung cancer (SCLC); however, the rapid development of cisplatin resistance limits its treatment effect. The detailed mechanisms of cisplatin-resistance, particularly in SCLC, remain unclear. We analyzed the differentially expressed genes (DEGs) between cisplatin-resist...

journal_title：Biochemical and biophysical research communications

authors： Ma K,Li S,Huo X,Guo M,Du X,Li C,Liu X,Lv J,Chen Z

更新日期：2020-12-10 00:00:00

abstract：:Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080 cells. Downregulation of Rac1 using specific siRNA probes result...

journal_title：Biochemical and biophysical research communications

authors： Niggli V,Schlicht D,Affentranger S

更新日期：2009-09-04 00:00:00

abstract：:Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no ...

journal_title：Biochemical and biophysical research communications

authors： Lascu I,Edwards B,Cucuianu MP,Deamer DW

更新日期：1988-10-31 00:00:00

abstract：:Elevated Na(+) concentration ([Na(+)]) in the cerebrospinal fluid (CSF) contributes to the development of salt-sensitive hypertension. CSF is formed by the choroid plexus (CP) in cerebral ventricles, and [Na(+)] in CSF is controlled by transporters in CP. Here, we examined the effect of high salt diet on the expressio...

journal_title：Biochemical and biophysical research communications

authors： Guo L,Meng J,Xuan C,Ge J,Sun W,O'Rourke ST,Sun C

更新日期：2015-05-29 00:00:00

abstract：:The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

journal_title：Biochemical and biophysical research communications

authors： Duan X,He ZG

更新日期：2011-04-01 00:00:00

abstract：AIMS:Mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) result in lipodystrophy, insulin resistance and diabetes. Autophagy is required for normal adipogenesis and adipose tissue development. The aim of this study was to determine whether impaired autophagy or excessive cell death underlie the adipoge...

journal_title：Biochemical and biophysical research communications

authors： Fernández-Galilea M,Tapia P,Cautivo K,Morselli E,Cortés VA

更新日期：2015-11-06 00:00:00

abstract：:Anchoring protein alphaKAP targets calmodulin kinase II (CaMKII) to the sarcoplasmic reticulum (SR), and in the rabbit is a substrate of CaMKII itself in fast-twitch, but not in slow-twitch muscle. This work was aimed at elucidating the molecular basis for differential phosphorylation of alphaKAP. Here we show that tw...

journal_title：Biochemical and biophysical research communications

authors： Damiani E,Sacchetto R,Salviati L,Margreth A

更新日期：2003-02-28 00:00:00

abstract：:We investigated the presence of the carbohydrate ligand for E-selectin on the cell surface of rat polymorphonuclear leukocytes (PMN). Rat PMN, isolated from peripheral blood, adhered to recombinant rat E-selectin-coated microplates. The adhesion was inhibited either by an anti-rat E-selectin monoclonal antibody (MAb),...

journal_title：Biochemical and biophysical research communications

authors： Misugi E,Kawamura N,Imanishi N,Tojo SJ,Morooka S

更新日期：1995-10-13 00:00:00

abstract：:Diphtheria toxin (DT) binds to a specific heparin-binding epidermal growth factor-like growth factor (HB-EGF) precursor that is expressed in DT-sensitive cells. DT binds to the cell-surface HB-EGF precursor with an apparent dissociation constant (KD) of approximately 1 x 10(-8) - 10(-9) M at 4 degreesC, a temperature ...

journal_title：Biochemical and biophysical research communications

authors： Brooke JS,Cha JH,Eidels L

更新日期：1998-07-20 00:00:00

abstract：:Multidrug resistance protein 2 (Mrp2) is considered the major mammalian membrane transporter of non-bile salt organic anions from liver to bile. Using Mrp2-deficient rats, we show that the protein is not essential for biliary excretion of biliverdin, its IIIalpha and XIIIalpha isomers, mesobiliverdin XIIIalpha or bili...

journal_title：Biochemical and biophysical research communications

authors： McDonagh AF,Lightner DA,Kar AK,Norona WS

更新日期：2002-05-10 00:00:00

abstract：:Exposure of [3H]-lysine labeled elastin to either purified myeloperoxidase plus H2O2 and halides or human neutrophils plus phorbol myristate acetate resulted in oxidation of lysine side chains quantitated as 3H2O release. In both the enzyme and cell system oxidation was blocked by azide, cyanide or catalase, but not b...

journal_title：Biochemical and biophysical research communications

authors： Clark RA,Szot S,Williams MA,Kagan HM

更新日期：1986-03-13 00:00:00

abstract：:Protein O-GlcNAcylation is proceeded by O-linked GlcNAc transferase (OGT) in nucleocytoplasm and is involved in many biological processes although its physiological role is not clearly defined. To identify the functional significance of O-GlcNAcylation, we investigated heat stress effects on protein O-GlcNAcylation. H...

journal_title：Biochemical and biophysical research communications

authors： Sohn KC,Lee KY,Park JE,Do SI

更新日期：2004-09-24 00:00:00

abstract：:Murine embryonic stem cell (mESC)-derived cardiomyocytes represent a promising source of cells for use in the development of models for studying early cardiac development as well as cell-based therapies in postnatal pathologies. Here, we report a highly efficient cardiac differentiation system in which high density em...

journal_title：Biochemical and biophysical research communications

authors： Lee MY,Cagavi Bozkulak E,Schliffke S,Amos PJ,Ren Y,Ge X,Ehrlich BE,Qyang Y

更新日期：2011-12-09 00:00:00

abstract：:In virus-infected cells, viral RNA with non-self structural pattern is recognized by DExD/Hbox RNA helicase, RIG-I. Once RIG-I senses viral RNA, it triggers a signaling cascade, resulting in the activation of genes including type I interferon, which activates antiviral responses. Overexpression of N-terminal caspase a...

journal_title：Biochemical and biophysical research communications

authors： Kageyama M,Takahasi K,Narita R,Hirai R,Yoneyama M,Kato H,Fujita T

更新日期：2011-11-11 00:00:00

abstract：:Cervical cancer is one of the most commonly diagnosed lethal malignancies among gynecological malignant tumors worldwide. Chemo-resistance is one of the key causal factors in cervical cancer death. Osthole (OST), a natural compound, exhibits various pharmacological activities, including anti-tumor effects. However, it...

journal_title：Biochemical and biophysical research communications

authors： Su J,Zhang F,Li X,Liu Z

更新日期：2019-06-25 00:00:00

abstract：:Helodermin is a peptide from the venom of the lizard Heloderma suspectum (Gila Monster) showing a high degree of sequence similarity with VIP, PHI and secretin in its N-terminal moiety. The present data support the presence of peptide(s) closely related to helodermin in the brain, gut and salivary glands of rat. In ou...

journal_title：Biochemical and biophysical research communications

authors： Robberecht P,De Graef J,Woussen MC,Vandermeers-Piret MC,Vandermeers A,De Neef P,Cauvin A,Yanaihara C,Yanaihara N,Christophe J

更新日期：1985-07-16 00:00:00

abstract：:In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of th...

journal_title：Biochemical and biophysical research communications

authors： Escande D,Thuringer D,Leguern S,Cavero I

更新日期：1988-07-29 00:00:00

abstract：:Cell growth and differentiation are opposite events in the myogenic lineage. Growth factors block the muscle differentiation program by inducing the expression of transcription factors that negatively regulate the expression of muscle regulatory genes like MyoD. In contrast, extracellular clues that induce cell cycle ...

journal_title：Biochemical and biophysical research communications

authors： Pedraza-Alva G,Zingg JM,Donda A,Pérez-Martínez L

更新日期：2009-11-13 00:00:00

abstract：:Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin. It is also noted that abnormal iron accumulation is one of the key factors to facilitate promotion and progression of cancer includi...

journal_title：Biochemical and biophysical research communications

authors： Toki Y,Sasaki K,Tanaka H,Yamamoto M,Hatayama M,Ito S,Ikuta K,Shindo M,Hasebe T,Nakajima S,Sawada K,Fujiya M,Torimoto Y,Ohtake T,Kohgo Y

更新日期：2016-08-05 00:00:00