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The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.

Abstract：

:In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Escande D,Thuringer D,Leguern S,Cavero I

doi

10.1016/0006-291x(88)90184-2

subject

Has Abstract

pub_date

1988-07-29 00:00:00

pages

620-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90184-2

journal_volume

154

pub_type

杂志文章

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