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Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum.

Abstract：

:The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass approximately 400,000. Incorporation of the ryanodine receptor into lipid bilayers induced single Ca2+ channel currents with conductance and kinetic behavior almost identical to that of native cardiac Ca2+ release channels. These results suggest that the cardiac ryanodine receptor comprises the Ca2+ release channel involved in excitation-contraction coupling in cardiac muscle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lai FA,Anderson K,Rousseau E,Liu QY,Meissner G

doi

10.1016/0006-291x(88)90613-4

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

441-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90613-4

journal_volume

151

pub_type

杂志文章

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