PrP N-terminal domain triggers PrP(Sc)-like aggregation of Dpl.

abstract：:Trypsin-like serine proteases are involved in diverse biological processes such as complement activation, tissue remodeling, cellular migration, tumor invasion, and metastasis. Here we report a novel human C1r-like serine protease analog, CLSPa, derived from dendritic cells (DC). The 487-residue CLSPa protein contains...

journal_title：Biochemical and biophysical research communications

authors： Lin N,Liu S,Li N,Wu P,An H,Yu Y,Wan T,Cao X

更新日期：2004-08-20 00:00:00

abstract：:Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation ...

journal_title：Biochemical and biophysical research communications

authors： Ni B,Farrar JS,Chen S,Lownik JC,Celi FS

更新日期：2018-07-02 00:00:00

abstract：:A protein extract prepared from the egg shell fiber-secreting region of the oviduct of Alligator mississippiensis was assayed for the presence of receptors for estrogen and progesterone. In the presence of [3H]-estradiol-17 beta, the extract contained an estrogen-binding activity which reached equilibrium at 25 degree...

journal_title：Biochemical and biophysical research communications

authors： Vonier PM,Guillette LJ Jr,McLachlan JA,Arnold SF

更新日期：1997-03-17 00:00:00

abstract：:The peroxidase and FAD-containing monooxygenase activities of porcine thyroid subcellular preparations were measured and it was observed that FAD-containing monooxygenase activity was considerably lower than that of peroxidase. The end product of 1-methyl-2[14C]thioimidazole oxidation catalysed by thyroid peroxidase w...

journal_title：Biochemical and biophysical research communications

authors： Paterson JR,Hood HT,Skellern GG

更新日期：1983-10-31 00:00:00

abstract：:Studies suggest that the anticancer drugs VP16-213 and VM26 produce cytotoxicity by inducing protein-associated DNA breakage in vivo through interaction with a yet unknown nuclear component. The effects of these drugs and their congeners on topoisomerase activities was investigated. VP16-213, VM26, and congeners activ...

journal_title：Biochemical and biophysical research communications

authors： Minocha A,Long BH

更新日期：1984-07-18 00:00:00

abstract：:Transcription factor GATA-6 plays essential roles in developmental processes and tissue specific functions through regulation of gene expression. GATA-6 mRNA utilizes two Met-codons in frame as translational initiation codons. Deletion of the nucleotide sequence encoding the PEST sequence (Glu(31)-Cys(46)) between the...

journal_title：Biochemical and biophysical research communications

authors： Takada K,Obayashi K,Ohashi K,Ohashi-Kobayashi A,Nakanishi-Matsui M,Maeda M

更新日期：2014-10-03 00:00:00

abstract：:ATP-binding cassette sub-family G member 2 (ABCG2) confers to the major phenotypes of side population (SP) cells, the cancer stem-like cells. In this study, the SP cells displayed a distinctly higher ABCG2 expression level, sphere formation efficiency (SFE) and growth rate even under hypoxia condition. CXCR4 overexpre...

journal_title：Biochemical and biophysical research communications

authors： He C,Zhang H,Wang B,He J,Ge G

更新日期：2018-10-28 00:00:00

abstract：:Receptor binding properties of the hemoglobin-derived nonapeptide VV-hemorphin 7 (Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH) were studied using both the unlabelled form and tritium-labelled derivative of the peptide. In binding studies using selective opioid radioligands, VV-hemorphin 7 exhibited a rank order of potency ...

journal_title：Biochemical and biophysical research communications

authors： Szikra J,Benyhe S,Orosz G,Darula Z,Piot JM,Fruitier I,Monory K,Hanoune J,Borsodi A

更新日期：2001-03-02 00:00:00

abstract：:Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that c...

journal_title：Biochemical and biophysical research communications

authors： Zhou F,Shen Y,Liu B,Chen X,Wan L,Peng D

更新日期：2017-03-18 00:00:00

abstract：:Aggregated β-amyloid peptides (Aβ) are neurotoxic and responsible for neuronal death both in vitro and in vivo. From the structural point of view, Aβ self-aggregation involves a conformational change in the peptide. Here, we investigated the relationship between conformational changes and amino acid residues of Aβ(40)...

journal_title：Biochemical and biophysical research communications

authors： Chen YR,Huang HB,Lo CJ,Wang CC,Su CL,Liu HT,Shiao MS,Lin TH,Chen YC

更新日期：2011-02-04 00:00:00

abstract：:To delineate the functional importance of the highly conserved triplet amino acid sequence, Asp-Arg-Tyr (DRY) among G protein-coupled receptors in the second intracellular loop, these residues of rat angiotensin II (Ang II) receptor type 1A (AT(1A)) were changed by alanine or glycine by site-directed mutagenesis. Thes...

journal_title：Biochemical and biophysical research communications

authors： Ohyama K,Yamano Y,Sano T,Nakagomi Y,Wada M,Inagami T

更新日期：2002-03-29 00:00:00

abstract：:In peplomycin-supersensitive Chinese hamster lung cells, the increase in poly(ADP-ribose) synthesizing activity following peplomycin treatment was significantly reduced as compared with the parental lung cells, suggesting that peplomycin-supersensitive lung cells may have some deficiency in DNA repair. On the contrary...

journal_title：Biochemical and biophysical research communications

authors： Ozawa S,Suzuki H,Yamaki H,Nishimura T,Tanaka N

更新日期：1988-03-30 00:00:00

abstract：:The vitamin D-dependent intestinal calcium binding protein gene is predominantly expressed in the intestine. In this report we have examined the possibility that methylation of the gene might play a role in its tissue-specific expression employing genomic Southern analysis. None of the Hpa II and Hha I sites examined ...

journal_title：Biochemical and biophysical research communications

authors： Darwish HM,Krisinger J,DeLuca HF

更新日期：1989-05-15 00:00:00

abstract：:The aim of this study was to understand the mechanism of action through which carnosine (beta-alanyl-L-histidine) acts as a quencher of cytotoxic alpha,beta-unsaturated aldehydes, using 4-hydroxy-trans-2,3-nonenal (HNE) as a model aldehyde. In phosphate buffer solution (pH 7.4), carnosine was 10 times more active as a...

journal_title：Biochemical and biophysical research communications

authors： Aldini G,Carini M,Beretta G,Bradamante S,Facino RM

更新日期：2002-11-15 00:00:00

abstract：:The ornithine decarboxylase gene of S. cerevisiae encodes a predicted protein of approximately 53 kD highly homologous with the ornithine decarboxylase of other species. However, the native enzyme has been reported as an 86 kD protein. Our molecular sieve analysis indicated a Mr = 110,000 for the native enzyme. SDS-PA...

journal_title：Biochemical and biophysical research communications

authors： Fonzi WA

更新日期：1989-08-15 00:00:00

abstract：:It is well-documented that large amounts of endotoxin produce hemorrhagic mucosal lesions in the stomach. To determine whether endotoxin, when injected at small doses, similarly exerts ulcerogenic actions, endotoxin (0.4-40 micrograms/kg) was injected into 24 hr-fasted rats. These small doses of endotoxin did not affe...

journal_title：Biochemical and biophysical research communications

authors： Tsuji K,Uehara A,Santos SB,Namiki M

更新日期：1993-12-30 00:00:00

abstract：BACKGROUND:During implantation, the blastocyst trophectoderm attaches to the endometrial epithelium and continues to differentiate into all trophoblast subtypes, which are the major components of a placenta. Aberrant trophoblast proliferation and differentiation are associated with placental diseases. However, due to e...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Wang K,Chandramouli GV,Knott JG,Leach R

更新日期：2013-07-12 00:00:00

abstract：:Dictyostelium discoideum possesses more EGF-like (EGFL) domains than any other sequenced eukaryote. Here we show that a synthetic EGFL peptide (DdEGFL1) based upon an amino acid sequence from a cysteine-rich Dictyostelium protein, functions extracellularly to enhance random cell motility and cAMP-mediated chemotaxis i...

journal_title：Biochemical and biophysical research communications

authors： Huber R,O'Day DH

更新日期：2009-02-06 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. Although the GIP receptor is known to be expressed in small intestine, the effects of GIP in small intestine are not fully understood. This study was designed to clarif...

journal_title：Biochemical and biophysical research communications

authors： Ogawa E,Hosokawa M,Harada N,Yamane S,Hamasaki A,Toyoda K,Fujimoto S,Fujita Y,Fukuda K,Tsukiyama K,Yamada Y,Seino Y,Inagaki N

更新日期：2011-01-07 00:00:00

abstract：:Tumor invasion of host tissues and trophoblastic penetration of the endometrium share common biological features. Both processes involve the invasion of basement membranes, an event that is initiated by adhesion of cancer or trophoblast cells to basement membrane components and particularly to laminin. Adhesion to thi...

journal_title：Biochemical and biophysical research communications

authors： van den Brûle FA,Price J,Sobel ME,Lambotte R,Castronovo V

更新日期：1994-05-30 00:00:00

abstract：:Renal dopamine receptors have been shown to play a critical role in ROS-dependent hypertension. D5 dopamine receptor deficient (D5-/-) mice are hypertensive and have increased systemic oxidative stress which is manifested in the kidney and the brain. To further investigate the underlying mechanisms of hypertension in ...

journal_title：Biochemical and biophysical research communications

authors： Stoelting M,Geyer M,Reuter S,Reichelt R,Bek MJ,Pavenstädt H

更新日期：2009-01-30 00:00:00

abstract：:Mycoplasma fermentans has been suspected as one of the causative pathogenic microorganisms of rheumatoid arthritis (RA) however, the pathogenic mechanism is still unclear. We, previously, reported that glycolipid-antigens (GGPL-I and III) are the major antigens of M. fermentans. Monoclonal antibody against the GGPL-II...

journal_title：Biochemical and biophysical research communications

authors： Kawahito Y,Ichinose S,Sano H,Tsubouchi Y,Kohno M,Yoshikawa T,Tokunaga D,Hojo T,Harasawa R,Nakano T,Matsuda K

更新日期：2008-05-02 00:00:00

abstract：:Protein insolubility is a major problem when producing recombinant proteins (e.g., to be used as antigens) from large cDNAs in Escherichia coli. Here, we describe a system using three convertible plasmid vectors to screen for soluble proteins produced in E. coli. This system experimentally identified any random cDNA f...

journal_title：Biochemical and biophysical research communications

authors： Nakayama M,Ohara O

更新日期：2003-12-19 00:00:00

abstract：:When c-Src and v-Src were immunoprecipitated together from hamster fibroblasts transformed by Rous sarcoma virus containing v-src oncogene, the total Src activity was almost threefold higher compared to c-Src activity in the control cells. The activity of v-Src immunoprecipitated separately, however, accounting for on...

journal_title：Biochemical and biophysical research communications

authors： Tuhácková Z,Vojtechová M,Hlavácek J,Ruzzene M,Sovová V,Pinna LA

更新日期：2002-01-18 00:00:00

abstract：:Lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria, induces strong proinflammatory responses, including the release of cytokines and nitric oxide from macrophage. In this study, we found that a murine macrophage-derived line, RAW264.7, became multinuclear through cell-cell fusion after inc...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi-Matsui M,Yano S,Matsumoto N,Futai M

更新日期：2012-08-24 00:00:00

abstract：:Burkitt's lymphoma is an aggressive B-cell neoplasm resulting from deregulated c-myc expression. We have previously shown that proliferation of Burkitt's lymphoma cell lines such as Ramos is markedly reduced by iron treatment. It has been shown that iron induces expression of c-myc which, owing to its transcriptional ...

journal_title：Biochemical and biophysical research communications

authors： Habel ME,Jung D

更新日期：2006-03-24 00:00:00

abstract：:The nucleotide sequence of human Go alpha was determined from a partial human brain cDNA clone and the sequence of the first two 5' coding exons of a human genomic Go alpha clone. Comparison of this sequence with bovine and rat Go alpha shows greater than 90% homology at the nucleotide and deduced amino acid level. Th...

journal_title：Biochemical and biophysical research communications

authors： Lavu S,Clark J,Swarup R,Matsushima K,Paturu K,Moss J,Kung HF

更新日期：1988-01-29 00:00:00

abstract：:Streptococcus mutans, a member of the viridans streptococci, is the etiologic agent of dental caries and is also a causative agent of subacute infective endocarditis. The generation of proteolytic molecules, such as plasmin, may be important in the pathogenesis of endocarditis caused by S. mutans. In this study, we de...

journal_title：Biochemical and biophysical research communications

authors： Jones MN,Holt RG

更新日期：2004-09-10 00:00:00

abstract：:We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet p...

journal_title：Biochemical and biophysical research communications

authors： Noda S,Mashima Y,Obazawa M,Kubota R,Oguchi Y,Kudoh J,Minoshima S,Shimizu N

更新日期：2000-10-05 00:00:00

abstract：:The presence of at least two distinct Mg2+- or Mn2+-dependent, Ca2+-independent endonuclease activities was shown in the myeloid leukemia cell line P39. One of them was recovered from nuclear extracts and the other from a cytoplasmic fraction. The molecular size of the former was 30 kDa in both gel filtration and acti...

journal_title：Biochemical and biophysical research communications

authors： Kawabata H,Anzai N,Masutani H,Hirama T,Hishita T,Dodo M,Masuda T,Yoshida Y,Okuma M

更新日期：1997-04-07 00:00:00