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Negative and positive elements in the promoter region of the human apoferritin L gene.

Abstract：

:We have characterized the promoter of the human gene coding for the apoferritin L subunit. Transient transfections of 5' and 3' deletion mutants indicate that the efficiency of the L promoter depends on both negative and positive cis-elements, located upstream and downstream of the transcription start point. DNaseI footprinting analysis of this DNA region revealed the presence of five protected segments. The most upstream one (element 1) corresponds to the negative cis-element and is recognized by factor(s) sharing a GC-sequence specificity. Three positive elements are in the region upstream of the start of transcription; a fifth positive cis-element (element 5) is localized in the first exon of the L gene.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

D'Agostino P,Faniello MC,Quaresima B,Bevilacqua MA,Tiano MT,Ammendola R,Cimino F,Costanzo F

doi

10.1006/bbrc.1995.2470

subject

Has Abstract

pub_date

1995-10-04 00:00:00

pages

329-37

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X85724709

journal_volume

215

pub_type

杂志文章

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