Estrogen modulates plasminogen promoter activity.

abstract：:Taxol (paclitaxel), a microtubule stabilizer with antitumor activity, mimics the actions of lipopolysaccharide (LPS) on murine macrophages (M phi). In the present study, a variety of synthetic analogs of paclitaxel were examined for their potencies to induce nitric oxide (NO) and tumor necrosis factor (TNF) production...

journal_title：Biochemical and biophysical research communications

authors： Kirikae T,Ojima I,Kirikae F,Ma Z,Kuduk SD,Slater JC,Takeuchi CS,Bounaud PY,Nakano M

更新日期：1996-10-03 00:00:00

abstract：:We designed a screen to identify starfish oocyte proteins able to bind monomeric cyclin B by affinity chromatography on a cyclin B splice variant displaying low affinity for cdc2. We identified a 15kDa protein previously described as a cdk-binding protein [Biochim. Biophys. Acta Mol. Cell Res. 1589 (2002) 219-231]. Cy...

journal_title：Biochemical and biophysical research communications

authors： Offner N,Derancourt J,Lozano JC,Schatt P,Picard A,Peaucellier G

更新日期：2003-01-03 00:00:00

abstract：:Although leukotriene B4 (LTB4) has been reported to stimulate monocytes and neutrophils, its role on dendritic cell (DC) activity has not been examined. Here, we investigated the expression of LTB4 receptor and the effect of LTB4 on human DC chemotaxis. We analyzed LTB4 receptors, BLT1 and BLT2, by using RT-PCR. DCs e...

journal_title：Biochemical and biophysical research communications

authors： Shin EH,Lee HY,Bae YS

更新日期：2006-09-22 00:00:00

abstract：:In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene. F...

journal_title：Biochemical and biophysical research communications

authors： Hu X,O'Donnell R,Srivastava SK,Xia H,Zimniak P,Nanduri B,Bleicher RJ,Awasthi S,Awasthi YC,Ji X,Singh SV

更新日期：1997-06-18 00:00:00

abstract：:Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Cu...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Tang N,Wang C,Xiao L,Yu M,Zhao L,Cai H,Han L,Xie C,Zhang Y

更新日期：2017-03-04 00:00:00

abstract：:We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal macrophages. Indomethacin a potent inhibitor of prostaglandin synthesis caused a dose-dependent augmentation of lipopolysaccharide induced interleukin production (up to 7-fold at 5 microM). ...

journal_title：Biochemical and biophysical research communications

authors： Kunkel SL,Chensue SW

更新日期：1985-04-30 00:00:00

abstract：:Glial cells have been shown to induce enzyme activities, which are characteristically high in brain capillaries, in cerebral and non cerebral endothelial cells in culture. We evaluated the activity of gamma-glutamyl transpeptidase (gamma GT) in freshly isolated (ex vivo) bovine blood (BEC) and lymphatic (LEC) endothel...

journal_title：Biochemical and biophysical research communications

authors： Weber E,Lorenzoni P,Raffaelli N,Cavina N,Sacchi G

更新日期：1996-08-23 00:00:00

abstract：:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in ...

journal_title：Biochemical and biophysical research communications

authors： Pickavance L,Tadayyon M,Williams G,Vernon RG

更新日期：1998-07-09 00:00:00

abstract：:The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

journal_title：Biochemical and biophysical research communications

authors： Tiong TS,Herington AC

更新日期：1991-10-31 00:00:00

abstract：:Numerous epidemiological data indicate that vitamin D receptor (VDR) signaling induced by its ligand or active metabolite 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) has anti-cancer activity in several colon cancers. 1α,25(OH)(2)D(3) induces the epithelial differentiation of SW480 colon cancer cells expressing VDR ...

journal_title：Biochemical and biophysical research communications

authors： Kouchi Z,Fujiwara Y,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2011-05-20 00:00:00

abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

journal_title：Biochemical and biophysical research communications

authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

更新日期：1992-10-15 00:00:00

abstract：:Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-κB (RANK)...

journal_title：Biochemical and biophysical research communications

authors： Wisutsitthiwong C,Buranaruk C,Pudhom K,Palaga T

更新日期：2011-11-18 00:00:00

abstract：:The human MEP1A gene encodes the meprin alpha subunit that consists of a protease domain conserved in the astacin family of metalloendopeptidases and several C-terminal interaction domains present in other proteins. Using the alpha subunit cDNA, we identified two clones from a human P1-derived artificial chromosome (P...

journal_title：Biochemical and biophysical research communications

authors： Jiang W,Beatty BG

更新日期：1999-07-22 00:00:00

abstract：:The synthesis of sufficient amounts of oligosaccharides is the bottleneck for the study of their biological function and their possible use as drug. As an alternative for chemical synthesis, we propose to use Escherichia coli as a "living factory." We have addressed the production of the Galp alpha(1-3)Galp beta(1-4)G...

journal_title：Biochemical and biophysical research communications

authors： Bettler E,Imberty A,Priem B,Chazalet V,Heyraud A,Joziasse DH,Geremia RA

更新日期：2003-03-14 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

journal_title：Biochemical and biophysical research communications

authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

更新日期：2010-12-10 00:00:00

abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

journal_title：Biochemical and biophysical research communications

authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

更新日期：2007-03-02 00:00:00

abstract：:Membranes of HL-60 cells were shown to possess saturable binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate, with nanomolar affinity (KD = 90 nM) and a density of 250 fmol/mg protein. The specificity of the binding sites for Ins(1,3,4,5)P4 was assessed by competition studies utilising a variety of inositol polyp...

journal_title：Biochemical and biophysical research communications

authors： Bradford PG,Irvine RF

更新日期：1987-12-16 00:00:00

abstract：:Mental status changes are usually associated with septic shock. However, the molecular mechanisms underlying physiological changes of the central nervous system (CNS) remain speculative. We have investigated the expression of interleukin (IL)-12, one of the central cytokines in inflammatory and immune responses, in th...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Shin SH

更新日期：1996-07-16 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play crucial roles in tumor development of osteosarcoma (OS). LncRNA PCAT6 was involved in the progression of multiple human cancers. However, the biological function of PCAT6 in OS remains largely unknown. We found that PCAT6 was elevated in OS tissues relative to that in their adjacent ...

journal_title：Biochemical and biophysical research communications

authors： Zhu C,Huang L,Xu F,Li P,Li P,Hu F

更新日期：2020-01-08 00:00:00

abstract：:Exosomal microRNAs(miRNAs) transfer from tumor to stromal cells is reportedly associated with cancer progression and metastasis in various epithelial cancers. However, the role of exosomal miRNA in the metastasis of osteosarcoma(OS) -the most common bone malignancy-still largely remains unknown. In this study, we puri...

journal_title：Biochemical and biophysical research communications

authors： Gong L,Bao Q,Hu C,Wang J,Zhou Q,Wei L,Tong L,Zhang W,Shen Y

更新日期：2018-06-02 00:00:00

abstract：:The human cDNA encoding a novel protein serine/threonine kinase most closely related to p70 S6 kinase was isolated from the human erythroleukemia cDNA library and termed p70(S6Kbeta). p70(S6Kbeta) has 67% amino acid identity in overall sequence with human p70(S6K), and the potential phosphorylation sites of p70(S6K) a...

journal_title：Biochemical and biophysical research communications

authors： Saitoh M,ten Dijke P,Miyazono K,Ichijo H

更新日期：1998-12-18 00:00:00

abstract：:Histone chaperones function in histone transfer and regulate the nucleosome occupancy and the activity of genes. HIRA is a replication-independent (RI) histone chaperone that is linked to transcription and various developmental processes. Here, we show that HIRA interacts with Mef2 and contributes to the activation of...

journal_title：Biochemical and biophysical research communications

authors： Yang JH,Choi JH,Jang H,Park JY,Han JW,Youn HD,Cho EJ

更新日期：2011-04-15 00:00:00

abstract：:Cyclosporin accumulation was reduced by 50% or more in multidrug- resistant CHRC5 CHO cells with high levels of P-glycoprotein expression compared to drug sensitive AuxB1 CHO cells. This difference could be overcome by verapamil which is known to interact with P-glycoprotein and reverse multidrug resistance. The diffe...

journal_title：Biochemical and biophysical research communications

authors： Goldberg H,Ling V,Wong PY,Skorecki K

更新日期：1988-04-29 00:00:00

abstract：:Oncogenic osteomalacia (OOM), X-linked hypophosphatemia (XLH), and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum calcitriol concentrations, normal serum concentrations of calcium and...

journal_title：Biochemical and biophysical research communications

authors： Bowe AE,Finnegan R,Jan de Beur SM,Cho J,Levine MA,Kumar R,Schiavi SC

更新日期：2001-06-22 00:00:00

abstract：:Endothelin-like immunoreactivity (-LI) was detected in the kidney, spleen, skeletal muscle, lung and in plasma of the pig. The highest tissue levels were found in the lung (1.5 +/- 0.07 pmol/g) and the lowest in the muscle (0.08 +/- 0.02 pmol/g). I.v. infusion of endothelin (20 pmol/kg/min for 20 min) increased plasma...

journal_title：Biochemical and biophysical research communications

authors： Pernow J,Hemsén A,Lundberg JM

更新日期：1989-06-15 00:00:00

abstract：:A recent report has shown that in vitro the RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. However, in vivo, it is well known that CGRP receptors are expressed in human coronary arteries and that a beneficial effect is observed in patients after CGRP i...

journal_title：Biochemical and biophysical research communications

authors： Frayon S,Cueille C,Gnidéhou S,de Vernejoul MC,Garel JM

更新日期：2000-04-21 00:00:00

abstract：:The presence of a significantly increased content of free-cystine in skin fibroblasts from both homozygotes and heterozygotes for cystinosis emphasizes the central role of cystine in this disease, even though the primary defect responsible for cystine accumulation is yet to be determined. The studies described in this...

journal_title：Biochemical and biophysical research communications

authors： Schneider JA,Rosenbloom FM,Bradley KH,Seegmiller JE

更新日期：1967-11-30 00:00:00

abstract：:Xanthurenic acid is an endogenous molecule leading to caspase-9 and -3 activation. Here we report that xanthurenic acid targets signalling proteins 14-3-3 into lysosomes leading to interruption protein/protein interaction. Xanthurenic acid changed the localisation of 14-3-3 in the cells. At a concentration of 10 and 2...

journal_title：Biochemical and biophysical research communications

authors： Malina HZ,Frueh BE

更新日期：2003-10-17 00:00:00

abstract：:The effect of phosphorylation of calcineurin on calmodulin (CaM) binding was examined using a synthetic peptide which contains the CaM-binding domain and the serine phosphorylation site. The peptide, corresponding to residues 391-414 of brain calcineurin A subunit, was rapidly phosphorylated by protein kinase C and Ca...

journal_title：Biochemical and biophysical research communications

authors： Calalb MB,Kincaid RL,Soderling TR

更新日期：1990-10-30 00:00:00

abstract：:This present study aims at establishing a novel in vivo gene delivery system for intra-articular tissues. Plasmid DNA (pDNA) carrying the firefly luciferase or enhanced green fluorescent protein (EGFP) genes as markers was injected into a joint space and electric stimuli were given percutaneously with a pair of electr...

journal_title：Biochemical and biophysical research communications

authors： Ohashi S,Kubo T,Kishida T,Ikeda T,Takahashi K,Arai Y,Terauchi R,Asada H,Imanishi J,Mazda O

更新日期：2002-05-24 00:00:00