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Altered distribution of hexokinase and glucokinase between parenchymal and nonparenchymal cells of rat liver after methapyrilene intoxication.

Abstract：

:The cell number as well as the hexokinase and glucokinase activity of liver parenchymal and nonparenchymal cells were studied in methapyrilene treated rats. The number of nonparenchymal cells was doubled after treatment with methapyrilene for two weeks while that of hepatocytes remained constant. The hexokinase activity was increased fourfold in the nonparenchymal cell fraction while it was unchanged in the parenchymal cells. The glucokinase activity was decreased in the hepatocytes to one third. Hence, the increased hexokinase activity was due to a proliferation of nonparenchymal cells rather than to a toxic dedifferentiation of hepatocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fischer W,Wagle SR,Katz NR

doi

10.1016/s0006-291x(83)80047-3

subject

Has Abstract

pub_date

1983-09-30 00:00:00

pages

1090-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)80047-3

journal_volume

115

pub_type

杂志文章

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