Can an X-ray dose threshold be measured for the induction of SOS repair activity in E. coli.

abstract：:The effect of the interleukin-1 receptor antagonist (IL-1ra) on development of hyperglycemia and insulitis in mice treated with multiple low doses of streptozotocin (STZ) was evaluated. C57BL/Ks mice were subjected to the following treatments: 1) Injections i.p. of phosphate-buffered saline (PBS) alone; 2) STZ (5 x 40...

journal_title：Biochemical and biophysical research communications

authors： Sandberg JO,Andersson A,Eizirik DL,Sandler S

更新日期：1994-07-15 00:00:00

abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MA,Moore CX,Pittner R,Beaumont K

更新日期：1993-11-30 00:00:00

abstract：:Nek2 is a mammalian protein kinase that is structurally homologous to NIMA, a mitotic regulator in Aspergillus nidulans. To understand the possible cellular processes in which Nek2 participates during the cell cycle, we investigated the expression and subcellular localization of Nek2 in mitotic cells. The Nek2 protein...

journal_title：Biochemical and biophysical research communications

authors： Ha Kim Y,Yeol Choi J,Jeong Y,Wolgemuth DJ,Rhee K

更新日期：2002-01-18 00:00:00

abstract：:Angiogenesis is a core hallmark of advanced cancers, especially in lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of lncRNAs in tumor angiogenesis remain largely unknown. Here we found that linc00665 depletion could markedly depressed proliferation and capillary tube formation of HUVECs i...

journal_title：Biochemical and biophysical research communications

authors： Cong Z,Diao Y,Li X,Jiang Z,Xu Y,Zhou H,Qiang Y,Wu H,Shen Y

更新日期：2020-06-25 00:00:00

abstract：:Superoxide production by neutrophils induced by 1-oleoyl-2-acetyl-sn-glycerol at concentrations below 100 microM was enhanced by extracellular calcium ions, while that of phorbol myristate acetate was unaffected. Verapamil, a calcium-channel blocker, more effectively inhibited the superoxide production induced by 1-ol...

journal_title：Biochemical and biophysical research communications

authors： Ozaki Y,Kume S,Ohashi T,Niwa Y

更新日期：1986-01-29 00:00:00

abstract：:The cell adhesion molecule integrin alphaMbeta2 associates with the urokinase-type plasminogen activator receptor (uPAR) on monocytes and neutrophils. uPAR also associates with members of the beta1 and beta3 integrins, and it modulates the ligand-binding function of these integrins. In this study, we showed that co-ex...

journal_title：Biochemical and biophysical research communications

authors： Tang ML,Kong LS,Law SK,Tan SM

更新日期：2006-09-29 00:00:00

abstract：:The inward rectifier potassium channel, Kir2.1, contributes to the I(K1) current in cardiac myocytes and is closely associated with atrial fibrillation. Strong evidences have shown that atrial dilatation or stretch may result in atrial fibrillation. However, the role of Kir2.1 channels in the stretch-mediated atrial f...

journal_title：Biochemical and biophysical research communications

authors： He Y,Xiao J,Yang Y,Zhou Q,Zhang Z,Pan Q,Liu Y,Chen Y

更新日期：2006-12-15 00:00:00

abstract：:Adult stem cells provide a promising alternative for the treatment of decompensated liver cirrhosis. Our previous study showed that peripheral blood monocytes (PBMCs) from decompensated liver cirrhosis could differentiate into hepatocyte-like cells in vitro. We here aimed to investigate the differential potential of t...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Han Y,Wang J,Liu J,He Y,Wang H,Fan D

更新日期：2008-07-11 00:00:00

abstract：:miR-130b was significantly up-regulated in osteosarcoma (OS) cells. Naked cuticle homolog 2 (NKD2) inhibited tumor growth and metastasis in OS by suppressing Wnt signaling. We used three miRNA target analysis tools to identify potential targets of miR-130b, and found that NKD2 is a potential target of miR-130b. Based ...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Li Y,Wang N,Yang L,Zhao W,Zeng X

更新日期：2016-03-18 00:00:00

abstract：:A novel aptameric enzyme subunit (AES) which can detect target DNAs has been developed. AES is an enzyme-inhibiting aptamer bearing a target-molecule binding site which can allosterically control enzymatic activity. The thrombin-inhibiting aptamer bearing a G-quartet structure was chosen as the enzyme-inhibiting aptam...

journal_title：Biochemical and biophysical research communications

authors： Yoshida W,Sode K,Ikebukuro K

更新日期：2006-09-15 00:00:00

abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

journal_title：Biochemical and biophysical research communications

authors： Takeya R,Takeshige K,Sumimoto H

更新日期：2000-01-07 00:00:00

abstract：:Binary enterotoxin of Clostridium perfringens (BEC), consisting of the components BECa and BECb, was recently identified as a novel enterotoxin produced by C. perfringens that causes acute gastroenteritis in humans. Although the detailed mechanism of cell intoxication by BEC remains to be defined, BECa shows both NAD+...

journal_title：Biochemical and biophysical research communications

authors： Kawahara K,Yonogi S,Munetomo R,Oki H,Yoshida T,Kumeda Y,Matsuda S,Kodama T,Ohkubo T,Iida T,Nakamura S

更新日期：2016-11-11 00:00:00

abstract：:Glutathione S-transferase Y-2 mRNA synthesis was induced in yeast Issatchenkia orientalis approximately 37-fold by cultivation with o-dinitrobenzene. A cDNA library complementary to poly (A)+RNA of I. orientalis grown with o-dinitrobenzene was screened by colony hybridization. Twenty positive clones were obtained from...

journal_title：Biochemical and biophysical research communications

authors： Tamaki H,Kumagai H,Tochikura T

更新日期：1990-10-30 00:00:00

abstract：:Specific, saturable EGF receptors were demonstrated in isolated rat pancreatic acini. Binding of EGF to these receptors was one-half maximal at 20 min and maximal at 120 min. Scatchard analyses revealed a single order of binding sites with a Kd of 4.90 nM. Following binding, EGF was rapidly internalized and converted ...

journal_title：Biochemical and biophysical research communications

authors： Korc M,Matrisian LM,Planck SR,Magun BE

更新日期：1983-03-29 00:00:00

abstract：:The recently detected Rieske iron-sulfur center in the membrane of the thermoacidophilic archaeon Sulfolobus acidocaldarius (Anemüller et al., 1993, FEBS Lett. 318, 61-64) was further characterized by EPR spectroscopy, coupled to redox-potentiometry and functional studies. The reduction potential is pH-dependent above...

journal_title：Biochemical and biophysical research communications

authors： Anemüller S,Schmidt CL,Schäfer G,Bill E,Trautwein AX,Teixeira M

更新日期：1994-07-15 00:00:00

abstract：:Expression of the mouse cytokeratin EndoA gene is regulated by an enhancer that is located 1 kilobases (kb) 3' downstream from the gene. The EndoA enhancer consists of six direct repeats with homology to the PEA3 motif in the polyoma virus enhancer core. The PEA3 motif binds to the proto-oncogene Ets product. In this ...

journal_title：Biochemical and biophysical research communications

authors： Hamazato F,Fujimura Y,Tamai Y,Takemoto Y,Matsushiro A,Nozaki M

更新日期：1993-04-30 00:00:00

abstract：:Reelin is a secreted glycoprotein essential for normal brain development and function. In the extracellular milieu, Reelin is subject to specific cleavage at two (N-t and C-t) sites. The N-t cleavage of Reelin is implicated in psychiatric and Alzheimer's diseases, but the molecular mechanism and physiological signific...

journal_title：Biochemical and biophysical research communications

authors： Kohno S,Kohno T,Nakano Y,Suzuki K,Ishii M,Tagami H,Baba A,Hattori M

更新日期：2009-02-27 00:00:00

abstract：:Osteoprotegerin (OPG) is a member of the TNF receptor superfamily and plays a critical role in the development of osteoclasts from precursor cells. OPG is produced by a variety of cells of mesenchymal origin and has been demonstrated to be present in osteoblasts and osteocytes. However, the mechanisms of regulation of...

journal_title：Biochemical and biophysical research communications

authors： Yang X,Halladay D,Onyia JE,Martin TJ,Chandrasekhar S

更新日期：2002-01-11 00:00:00

abstract：:We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal macrophages. Indomethacin a potent inhibitor of prostaglandin synthesis caused a dose-dependent augmentation of lipopolysaccharide induced interleukin production (up to 7-fold at 5 microM). ...

journal_title：Biochemical and biophysical research communications

authors： Kunkel SL,Chensue SW

更新日期：1985-04-30 00:00:00

abstract：:The mechanism of how PPARgamma decrease gluconeogenic gene expressions in liver is still unclear. Since PPARgamma is a transcriptional activator, it requires a mediator to decrease the transcription of gluconeogenic genes. Recently, SHP has been shown to mediate the bile acid-dependent down regulation of gluconeogenic...

journal_title：Biochemical and biophysical research communications

authors： Kim HI,Koh YK,Kim TH,Kwon SK,Im SS,Choi HS,Kim KS,Ahn YH

更新日期：2007-08-24 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types. The study is aimed to explore i...

journal_title：Biochemical and biophysical research communications

authors： Wang EW,Han YY,Jia XS

更新日期：2018-01-22 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a well-characterized ubiquitous enzyme involved in the glycolytic pathway. It catalyzes the reversible isomerization of D-glucopyranose-6-phosphate and D-fructofuranose-6-phosphate and is present in all living cells. However, there is interspecies variation at the level of the primary...

journal_title：Biochemical and biophysical research communications

authors： Mathur D,Ahsan Z,Tiwari M,Garg LC

更新日期：2005-11-18 00:00:00

abstract：:The contribution of four transport pathways to Li+ influx in human, chicken and eel erythrocytes was studied. All pathways were measured simultaneously in each kind of blood sample to avoid possible temporal variations in transport parameters. We found that: 1) Li+ influx via Na(+)-K+ pump increased 2-3 fold in the or...

journal_title：Biochemical and biophysical research communications

authors： Romano L,Battaglia M,Cordì R,Rinaldi C,Leucci S,Amato A

更新日期：1995-05-05 00:00:00

abstract：:Epidermal growth factor receptor (EGF-R) is a widely expressed ligand-dependent tyrosine kinase. The tyrosine residue at 845 in EGF-R corresponds to Y416 of v/c-src kinase, which is highly conserved and functionally important in many tyrosine kinases. To clarify the functional role of Y845, we constructed a mutant hum...

journal_title：Biochemical and biophysical research communications

authors： Gotoh N,Tojo A,Hino M,Yazaki Y,Shibuya M

更新日期：1992-07-31 00:00:00

abstract：:Previous reports have shown that 12-0-tetradecanoylphorbol-13-acetate can activate phospholipase D in human peripheral blood mononuclear cells as measured by an enzyme-catalyzed transphosphatidylation reaction (phosphatidylethanol formation). In the present study, the mononuclear cells were fractionated by two procedu...

journal_title：Biochemical and biophysical research communications

authors： Kinsky SC,Loader JE,Benedict SH

更新日期：1989-07-31 00:00:00

abstract：:Most formal methods for analyzing the divergent evolution of protein sequences assume a Markov model where position i in a polypeptide chain undergoes amino acid substitution independently from position i + 1. The large number of aligned homologous sequence pairs available from the exhaustive matching of the protein s...

journal_title：Biochemical and biophysical research communications

authors： Gonnet GH,Cohen MA,Benner SA

更新日期：1994-03-15 00:00:00

abstract：:Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen. In the present st...

journal_title：Biochemical and biophysical research communications

authors： Krishnamurthi S,Kakkar VV

更新日期：1988-11-15 00:00:00

abstract：:Osteoarthritis (OA) is the most common form of joint disease. The development of inflammation have been considered to play a key role during the progression of OA. Regulatory pathways are known to play crucial roles in many pathogenic processes. Thus, deciphering these risk regulatory pathways is critical for elucidat...

journal_title：Biochemical and biophysical research communications

authors： Song Z,Zhang C,He L,Sui Y,Lin X,Pan J

更新日期：2018-06-12 00:00:00

abstract：:Metallothionein (MT) is effective in the prevention of diabetic cardiomyopathy, and hypoxia-inducible factor-1 (HIF-1) is known to control vascular endothelial growth factor (VEGF) gene expression and regulate angiogenesis in diabetic hearts. We examined whether or not MT affects HIF-1 activity in the heart of diabeti...

journal_title：Biochemical and biophysical research communications

authors： Feng W,Wang Y,Cai L,Kang YJ

更新日期：2007-08-17 00:00:00

abstract：:Parathyroid hormone secretion is negatively regulated by calcium. We utilized calcium channel agents: +202-791, a calcium channel agonist and -202-791, a calcium channel antagonist, to evaluate the role of calcium channels in PTH secretion. +202-791 inhibited PTH release from bovine parathyroid cells and the antagonis...

journal_title：Biochemical and biophysical research communications

authors： Fitzpatrick LA,Brandi ML,Aurbach GD

更新日期：1986-07-31 00:00:00