Identification of antigenic epitopes recognized by Mac-2 binding protein-specific cytotoxic T lymphocytes for use in cancer immunotherapy.

abstract：:Transforming growth factor-beta1 and fibroblast growth factor-2 play very important roles in fibroblast proliferation and collagen expression. These processes lead to the formation of joint adhesions through the SMAD and MAPK pathways, in which extracellular signal-regulated kinase (ERK)2 is considered to be crucial. ...

journal_title：Biochemical and biophysical research communications

authors： Li F,Ruan H,Fan C,Zeng B,Wang C,Wang X

更新日期：2010-01-01 00:00:00

abstract：:Insulin receptor substrates (IRSs) are phosphorylated by activated insulin/insulin-like growth factor (IGF)-I receptor tyrosine kinases. Phosphotyrosyl IRSs are recognized by signaling molecules possessing src homology region 2 (SH2) domains, which mediate various insulin/IGF bioactivities. However, we have shown that...

journal_title：Biochemical and biophysical research communications

authors： Fukushima T,Arai T,Ariga-Nedachi M,Okajima H,Ooi Y,Iijima Y,Sone M,Cho Y,Ando Y,Kasahara K,Ozoe A,Yoshihara H,Chida K,Okada S,Kopchick JJ,Asano T,Hakuno F,Takahashi S

更新日期：2011-01-21 00:00:00

abstract：:Previous studies have demonstrated an inverse relationship between estrogen receptor (ER) and epidermal growth factor receptor (EGF-R) gene expression in human breast cancer cells. This relationship was further investigated in MCF 7 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). Exposure to 10 nM TPA r...

journal_title：Biochemical and biophysical research communications

authors： Lee CS,Koga M,Sutherland RL

更新日期：1989-07-14 00:00:00

abstract：:The relationship between oxidative stress and Bcl-2 expression was investigated in two different experimental models of oxidative stress. Acute oxidative stress was assessed by measuring, with fluorescence microscopy and cytofluorimetry, the increase in fluorescence of the oxidation-sensitive probe dihydrorhodamine 12...

journal_title：Biochemical and biophysical research communications

authors： Longoni B,Boschi E,Demontis GC,Marchiafava PL,Mosca F

更新日期：1999-07-05 00:00:00

abstract：:Green fluorescent protein (GFP)-tagged phospholipase C (PLC)-delta1 and its mutants were expressed in Madin-Darby canine kidney (MDCK) cells. GFP-PLC-delta1 or the GFP-tagged pleckstrin homology (PH) domain of PLC-delta1 itself was found to be predominantly localized at the plasma membrane. The DeltaPH mutant or a sit...

journal_title：Biochemical and biophysical research communications

authors： Fujii M,Ohtsubo M,Ogawa T,Kamata H,Hirata H,Yagisawa H

更新日期：1999-01-19 00:00:00

abstract：:Limited proteolysis converts the 39200 molecular weight catalytic domain of rat tyrosine hydroxylase to a monomer with a molecular weight of 37600. The purified monomer is almost fully active, with minor changes in kinetic parameters at pH 7. Mass spectral analysis and N-terminal sequencing of the proteolytically gene...

journal_title：Biochemical and biophysical research communications

authors： Lohse DL,Fitzpatrick PF

更新日期：1993-12-30 00:00:00

abstract：:We studied the regulation of glutathione (GSH) synthesis and characterised the 5'-promoter region of the gamma-glutamylcysteine synthetase-heavy subunit (gammaGCS-HS) gene in human alveolar type II cells (A549) following exposure to menadione (MQ) and hydrogen peroxide (H2O2). Both MQ (100 microM) and H2O2 (100 microM...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Bel A,Mulier B,Lawson MF,Harrison DJ,Macnee W,Smith CA

更新日期：1996-12-24 00:00:00

abstract：:GPI-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts. To study the interactions between the lipidic GPI-anchor of the protein and phospholipids, we used phosphatidylcholine monolayers at the air-water interface as a biomimetic membrane sy...

journal_title：Biochemical and biophysical research communications

authors： Kouzayha A,Besson F

更新日期：2005-08-12 00:00:00

abstract：:The inhibitory effect of sodium selenite on biliary secretion of methyl mercury was examined in rats. The biliary secretion of methyl mercury in rat treated with 1 mumol/kg of methyl mercury was significantly decreased by administration of selenite at doses of 0.05 mumol/kg or higher. In rats given 10 mumol/kg of meth...

journal_title：Biochemical and biophysical research communications

authors： Urano T,Imura N,Naganuma A

更新日期：1997-10-29 00:00:00

abstract：:We found new photochemical intermediate of third rhodopsin-like pigment (tR) or slow cycling rhodopsin-like pigment (sR) in Halobacterium halobium, which was produced by simultaneous illumination with red and blue light. This illumination is employed for measurements of negative phototaxis. The formation of this inter...

journal_title：Biochemical and biophysical research communications

authors： Tomioka H,Kamo N,Takahashi T,Kobatake Y

更新日期：1984-09-28 00:00:00

abstract：:Molecular structure of the ligand binding domain of hAhR has been modelled by homology modelling techniques and used for docking simulations with dioxin and nine more xenobiotics and endogenous ligands. The study evidences that different sites may bind these ligands, whereas only one binding site has been previously i...

journal_title：Biochemical and biophysical research communications

authors： Salzano M,Marabotti A,Milanesi L,Facchiano A

更新日期：2011-09-23 00:00:00

abstract：:Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2002-10-04 00:00:00

abstract：:The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin. The material was reduced and alkylated and the A- and the B-chain were separated by reversed phase chromatography and subjected to Edman degradation and amino acid analysis. It was shown that the A-chain c...

journal_title：Biochemical and biophysical research communications

authors： Hellman U,Wernstedt C,Westermark P,O'Brien TD,Rathbun WB,Johnson KH

更新日期：1990-06-15 00:00:00

abstract：:The expression of mouse CYP27B1 in Escherichia coli has been dramatically enhanced by coexpression of GroEL/ES. To reveal the enzymatic properties of CYP27B1, we measured its hydroxylation activity toward vitamin D3 and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) in addition to the physiological substrate 25(OH)D3. Surpri...

journal_title：Biochemical and biophysical research communications

authors： Uchida E,Kagawa N,Sakaki T,Urushino N,Sawada N,Kamakura M,Ohta M,Kato S,Inouye K

更新日期：2004-10-15 00:00:00

abstract：:Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological proc...

journal_title：Biochemical and biophysical research communications

authors： Zhao XL,Li GZ,Sun B,Zhang ZL,Yin YH,Tian YS,Li H,Li HL,Wang de S,Zhong D

更新日期：2010-02-19 00:00:00

abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

更新日期：2007-06-22 00:00:00

abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Tamura S,Takagi H

更新日期：1985-01-16 00:00:00

abstract：:The gonadotropin secretory response of anterior pituitary cells to phorbol esters includes both extracellular Ca2(+)-dependent and -independent components (Stojilković et al, 1988; J. Biol. Chem. 263, 17301-17306, 1988). In cultured pituitary cells, measurements of [Ca2+]i using Fura-2 and of LH release during cell pe...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Stojilković SS,Iida T,Krsmanović LZ,Omeljaniuk RJ,Catt KJ

更新日期：1990-07-16 00:00:00

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:A dot-blot hybridization procedure with synthetic oligonucleotide probes is reported, which allows the quantitative titration in genomic DNA of variant forms of repeated genes differing by a single nucleotide change. It involves the utilization of a pair of 22-base long oligonucleotides matching the two variant sequen...

journal_title：Biochemical and biophysical research communications

authors： Nicoloso M,Liang HQ,Bachellerie JP

更新日期：1989-03-31 00:00:00

abstract：:In a span of approximately 13 kb, two genomic fragments showing an obvious overlap encoded the 1,192 base pair (bp) cDNA sequence for human H-protein. Because of the close similarity in the genomic organization comprised of five exons to that for the chicken H-protein gene, this region was assigned to the true H-prote...

journal_title：Biochemical and biophysical research communications

authors： Koyata H,Hiraga K

更新日期：1991-08-15 00:00:00

abstract：:Enzymes belonging to the S9 family of prolyl oligopeptidases are of interest because of their pharmacological importance and have a non-catalytic β-propeller domain. In this study, we found that the oxidation of Met203, which lies on surface of the β-propeller domain, leads to change in the substrate specificity of er...

journal_title：Biochemical and biophysical research communications

authors： Tokai S,Bito T,Shimizu K,Arima J

更新日期：2017-05-27 00:00:00

abstract：:N-Palmitoyl-(S)-seryl-(S)-seryl-(S)-asparaginyl-(S)-alanine (Palmitoyl-tetrapeptide) is an analogue of the N-terminal part of the lipoprotein from the outer membrane of Escherichia coli. It was prepared by chemical synthesis and tested for biological activity in in vitro lymphocyte culture systems. In spleen cells of ...

journal_title：Biochemical and biophysical research communications

authors： Bessler WG,Cox M,Wiesmüller KH,Jung G

更新日期：1984-05-31 00:00:00

abstract：:Here we describe differences in the formation of the epinephrine-induced Ca2+ transients between parent and Ki-ras-transformed NIH3T3 fibroblasts. These transients proved to be the results of an efflux from both the thapsigargin-sensitive and -insensitive intracellular pools. While the epinephrine-induced detachment o...

journal_title：Biochemical and biophysical research communications

authors： Tóth S,Fu T,Nozawa Y,Csaba G

更新日期：1993-01-29 00:00:00

abstract：:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

journal_title：Biochemical and biophysical research communications

authors： Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

更新日期：2000-09-24 00:00:00

abstract：:The Arabidopsis wall-associated receptor kinase, WAK1, is a member of WAK family that links the plasma membrane to the extracellular matrix. A glycine-rich secreted protein, AtGRP-3, was previously shown to regulate WAK1 functions through binding to the extracellular domain of WAK1. In this study, we sought to determi...

journal_title：Biochemical and biophysical research communications

authors： Yang EJ,Oh YA,Lee ES,Park AR,Cho SK,Yoo YJ,Park OK

更新日期：2003-06-13 00:00:00

abstract：:Cigarette smoke (CS)-induced emphysema is attributable to matrix metalloproteinase-12 (MMP-12) in mice, however, a relationship between CS and MMP-12 is absent in human emphysema. Here, we show that cigarette smoke condensate (CSC) induces MMP-12 gene expression in airway-like epithelia through a hydrogen peroxide (H(...

journal_title：Biochemical and biophysical research communications

authors： Lavigne MC,Eppihimer MJ

更新日期：2005-04-29 00:00:00

abstract：:The peroxisome proliferator activated receptors (PPARs) alpha, beta/delta, and gamma are novel nuclear hormone receptors activated by long chain fatty acids and synthetic ligands and which regulate lipid metabolism. Recent studies have detected PPARgamma mRNA in human mammary tumor cell lines. The current study examin...

journal_title：Biochemical and biophysical research communications

authors： Gimble JM,Pighetti GM,Lerner MR,Wu X,Lightfoot SA,Brackett DJ,Darcy K,Hollingsworth AB

更新日期：1998-12-30 00:00:00

abstract：:The fluorescence decay of adenosine in 1:1 glycol/water glass has been determined at 77K using narrow pulse (700 ps) laser excitation at 290 nm and fluorescence detection with a scanned narrow-gate (100 ps) fast sampler together with digital averaging. Data analysis by re-iterative non-linear least squares convolution...

journal_title：Biochemical and biophysical research communications

authors： Hart LP,Daniels M

更新日期：1989-07-31 00:00:00

abstract：:BET inhibitors (BETi) exert an excellent anti-cancer activity in breast cancer. However, the identification of new potential targets to enhance breast cancer sensitivity to BETi is still an enormous challenge. Both NR5A2 and NCOA3 are frequently involved in cancer cells resistance to chemotherapy, also associated with...

journal_title：Biochemical and biophysical research communications

authors： Qiao J,Chen Y,Mi Y,Jin H,Huang T,Liu L,Gong L,Wang L,Wang Q,Zou Z

更新日期：2020-09-17 00:00:00